A5004325190- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- DNA Repair Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Advanced Radiotherapy Techniques
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Effects of Radiation Exposure
- Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
Fudan University Shanghai Cancer Center
2018-2025
Shanghai Medical College of Fudan University
2018-2025
Shanghai Clinical Research Center
2022-2025
Soochow University
2025
Shanghai University of Traditional Chinese Medicine
2025
Yueyang Hospital
2025
Qilu Hospital of Shandong University
2024
Shanghai Institute of Hematology
2022-2024
Nanjing Drum Tower Hospital
2023
Fudan University
2019-2022
Bone is a frequent metastatic site of non-small cell lung cancer (NSCLC), and bone metastasis (BoM) presents significant challenges for patient survival quality life. Osteolytic BoM characterised by aberrant differentiation malfunction osteoclasts through modulation the TGF-β/pTHrP/RANKL signalling pathway, but its upstream regulatory mechanism unclear. In this study, we found that lncRNA-SOX2OT was highly accumulated in exosomes derived from peripheral blood NSCLC patients with higher...
Abstract Objectives Stereotactic body radiotherapy ( SBRT) is a treatment option for patients with early-stage non-small cell lung cancer (NSCLC) who are unfit surgery. Some may experience distant metastasis. This study aimed to develop and validate radiomics model predicting metastasis in NSCLC treated SBRT. Methods Patients at five institutions were enrolled this study. Radiomics features extracted based on the PET/CT images. After feature selection training set (from Tianjin), CT-based...
Osimertinib, as a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), showed more potent efficacy against brain metastasis (BM) in untreated EGFR-mutant nonsmall cell lung cancer (NSCLC) the FLAURA study. However, overall survival (OS) benefit of osimertinib and clinical value cranial local therapy (CLT) these patients remain undetermined. Here we conducted retrospective study involving NSCLC with BMs receiving first-line or first-generation EGFR-TKIs....
Radiation-induced lung injury (RILI) is a prevalent complication of thoracic radiotherapy in cancer patients. A comprehensive understanding the underlying mechanisms RILI essential for development effective prevention and treatment strategies.To investigate RILI, we utilized mouse model that received 12.5 Gy whole-thoracic irradiation. The evaluation was performed using combination quantitative real-time polymerase chain reaction (qRT-PCR), enzyme-linked immunosorbent assay (ELISA),...
Lung cancer is the leading cause of cancer-associated mortalities worldwide. Non-small-cell lung (NSCLC) main reason for cancer-relevant death and constitutes 80% cases. Long noncoding RNAs (lncRNAs) have been found to be related different kinds cancer. played important roles in regulating pathological physiological processes numerous cancers. To explore novel adenocarcinoma-associated lncRNAs, we analyzed TCGA database that lncRNA SNHG3 was significantly upregulated adenocarcinoma....
Introduction: Brain is a major site of metastasis for lung cancer, and effective therapy developed brain (BM) limited. Prophylactic cranial irradiation (PCI) has been shown to reduce BM rate improve survival in small cell but this result was not replicated unselected non-small cancer (NSCLC) had the risk inducing neurocognitive dysfunctions. We aimed develop radiomics prediction model stratification NSCLC patients. Methods: 256 patients with no at baseline magnetic resonance imaging (MRI)...
To investigate the clinical implications of serum carcinoembryonic antigen (CEA), neuron specific enolase (NSE), and pro-gastrin-releasing peptide (ProGRP) in small cell esophageal carcinoma (SCEC). Receiver operating characteristic (ROC) curves were used to determine area under curve (AUC), sensitivity, specificity markers for differentiating SCEC from patients with squamous (ESCC), adenocarcinoma (EAC) healthy subjects. The combination ProGRP NSE demonstrated significant diagnostic...
Appropriate local therapy may provide survival benefits in oligometastatic non-small cell lung cancer (NSCLC) patients receiving chemotherapy or targeted therapy. However, its roles immunotherapy-treated have not been fully understood. PD-1/PD-L1 inhibitor-treated metastatic NSCLC were enrolled a prospective multi-center observational study (NCT04766515) from September 2020 to March 2023. Those without driver mutations, with measurable disease and harboring included. Progression-free (PFS)...
Hypothyroidism is a common sequela after radiotherapy for nasopharyngeal carcinoma (NPC). Magnetic resonance imaging (MRI) has gained prominence in thyroid imaging, leveraging its non-ionizing radiation, high spatial resolution, multiparameter and multidirectional imaging. Few previous studies have investigated the evaluation of radiation-induced injury by MRI. MRI data 32 patients who were first diagnosed with our hospital from April 2015 to 2024 underwent department retrospectively...
Cancer-associated fibroblasts are an essential part of the tumor immunoenvironment, playing key roles in malignancy progression and treatment response. This study was to characterize cancer-associated fibroblasts-related genes (CAFs) colorectal cancer (CRC) establish signature associated with CAF for prognosis prediction. We downloaded single-cell RNA sequencing (scRNA-seq) data from GEO database bulk RNA-seq TCGA identify differentially expressed related fibroblasts. In set, DEGs were...
There was no study investigating real-world utilization and outcome of LCT in Osimertinib-treated NSCLC with oligo-residual disease. This to analyze the clinical value local consolidative therapy (LCT) non-small cell lung cancer (NSCLC) patients disease.Patients receiving standard Osimertinib treatment developing disease (five or fewer residual metastatic lesions) were retrospectively reviewed. Local therapies performed tumor lesions primary site before failure considered as LCT.Of 108...
Abstract Objectives The SWORD trial is the first multicenter, single arm, phase II study assessing safety and efficacy of a PD-1 inhibitor (Sintilimab), stereotactic body radiotherapy (SBRT) granulocyte–macrophage colony stimulating factor (GM-CSF) in advanced non-small cell lung cancer (NSCLC) without sensitizing driver mutations. A run-in was conducted to determine tolerability experimental treatment. Materials methods Twenty metastatic NSCLC patients who failed first-line chemotherapy...
Grade 3 (G3) gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are rare, and there is no report specifically dealing with patients of liver metastases from G3 GEP NETs. From January 2004 to 2014, 36 conservative NET were retrospectively identified hepatobiliary centers in China. The clinical features treatment outcomes analyzed. Aggressive locoregional treatments (LT, including cytoreductive surgery, radiofrequency ablation, liver-directed intra-arterial intervention) systemic...
Detecting genetic mutations in circulating cell-free DNA (cfDNA) is a promising approach of liquid biopsy. Between June 2014 and May 2015, 168 plasma samples were collected monthly from 20 patients with metastatic lung adenocarcinoma epidermal growth factor receptor (EGFR) mutation receiving gefitinib therapy. Clinically relevant EGFR mutations, including exon 19 deletion, L858R T790M, quantified using droplet digital polymerase chain reaction. In baseline samples, (95.0%) had the same...