A5019519148- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cleft Lip and Palate Research
- Ginseng Biological Effects and Applications
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- dental development and anomalies
- Cancer Research and Treatments
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Toxin Mechanisms and Immunotoxins
- Craniofacial Disorders and Treatments
- Bone Metabolism and Diseases
- Asthma and respiratory diseases
- Histone Deacetylase Inhibitors Research
- Retinal Development and Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Allergic Rhinitis and Sensitization
- Ferroptosis and cancer prognosis
- Congenital Ear and Nasal Anomalies
- Cancer Mechanisms and Therapy
Chengdu University of Traditional Chinese Medicine
2025
Zhongshan Hospital of Xiamen University
2025
Jinan University
2012-2025
Guangxi University
2024
Hunan Academy of Traditional Chinese Medicine
2024
Dali University
2024
Sichuan University
2024
Zigong First People's Hospital
2023
Wuhan No.1 Hospital
2022
Mengchao Hepatobiliary Hospital
2022
Tissue and molecular heterogeneities are present in the developing secondary palate along anteroposterior (AP) axis mice. Here, we show that Wnt5a its receptor Ror2 expressed a graded manner AP of palate. deficiency leads to complete cleft palate, which exhibits distinct phenotypic alterations at histological, cellular levels anterior posterior regions We demonstrate there is directional cell migration within In absence Wnt5a, this does not occur. Genetic studies vitro organ culture assays...
microRNAs play an important roles in cell growth, differentiation, proliferation and apoptosis. They can function either as tumor suppressors or oncogenes. We found that the overexpression of miR-192 inhibited A549, H460 95D cells, tumorigenesis a nude mouse model. Both caspase-7 PARP protein were activated by miR-192, thus suggesting induces apoptosis through caspase pathway. Further studies showed retinoblastoma 1 (RB1) is direct target miR-192. Over-expression decreased RB1 mRNA levels...
Dysfunction of vascular smooth muscle cells (VSMCs) is key in the pathogenesis proliferative cardiovascular diseases, including atherosclerosis and post-angioplasty restenosis. However, to date, molecular mechanisms this pathological process have not been elucidated. Growing evidence indicates that microRNAs (miRNAs) are a class novel gene regulators. Recently, miR-146a was shown be highly expressed rat balloon-injured walls as well peripheral blood mononuclear (PBMCs) from patients with...
Extensive efforts have been made to explore members of the IL-10 family as potential therapeutic strategies for various diseases; however, their biological role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains underexplored. Gene expression datasets GSE136825, GSE179265, and GSE196169 were retrieved from Expression Omnibus (GEO) analysis. Candidate genes identified by intersecting differentially expressed (DEGs) between CRSwNP control groups (DEGsall) those high- low-score within...
Abstract Antisense oligonucleotide (ASO) therapy holds promise in gene but faces challenges due to poor delivery efficiency and limited evaluation models. This investigation employs magnetic nanoparticles (MNPs) augment the of ASOs. It assesses their distribution therapeutic efficacy across various models, including retinal explants from mice macaques or human inner ear organoids. Retinal both monkeys are methodically arranged expose ganglion cell layer (GCL) photoreceptor (PL). MNPs...
Hepatic artery ligation (HAL), transarterial embolization (TAE), and chemoembolization (TACE) have been treatment choices for unresectable hepatocellular carcinoma (HCC). Obstruction of tumor blood supply is one the most important mechanisms these therapeutics measures. Here we introduced HAL into a metastatic human HCC orthotopic nude mouse model (using MHCC97L HepG2 cell lines) to examine effects hepatic flow obstruction on potential cells, investigate underlying effects. Our results...
Endocrine resistance and metastatic progression are primary causes of treatment failure in breast cancer. While mitogen activated protein kinases (MAPKs) known to promote ligand-independent cell growth, the role MEK5-ERK5 pathway clinical carcinoma remains poorly understood. Here, we demonstrated increased ERK5 activation 30 39 (76.9%) tumor samples, as well across cancer systems. Overexpression MEK5 MCF-7 cells promoted both hormone-dependent hormone-independent tumorigenesis vitro vivo...
Abstract Polycomb group (PcG) proteins are required for maintaining the repressed state of developmentally important genes such as homeotic genes. Polycomblike ( Pcl ), a member PcG with two characteristic PHD finger motifs, was shown to strongly enhance effects in Drosophila . Three exist mouse genome, their function largely unknown. Our previous studies demonstrate that chick Pcl2 is essential left–right asymmetry by silencing Shh expression right side node (Wang et al., [ 2004b ]...
Poly(ADP-ribose) polymerase-1 (PARP-1) which mediates poly-ADP-ribosylation, has been extensively investigated in carcinoma compared to arginine ADP-ribosyltransferase 1 (ART1), mono‑ADP‑ribosylation. Previous studies have demonstrated that these enzymes promote proliferation and tumor development colon carcinoma. However, whether there is any association between PARP-1 ATR1 carcinoma, remains unelucidated. In this study, using immunohistochemical analysis, we detected a higher expression of...
Hypoxia/reoxygenation (H/R) is one of the main causes coronary artery disease (CAD), which primarily induced by damage to endothelial cells (CAECs). Glycyrrhizic acid (GA) a natural and abundant pentacyclic triterpenoid glycoside licorice root extract, it has been reported elicit protective effects against hypoxia, inflammation apoptosis in ischemic myocardium; therefore, GA may serve as promising therapeutic agent for ischemia-associated CAD. In present study, H/R-induced injury CAECs were...