A5004251439- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- Pharmacological Effects and Assays
- Analytical chemistry methods development
- Toxic Organic Pollutants Impact
- Water Quality Monitoring and Analysis
- Metabolomics and Mass Spectrometry Studies
- Water Treatment and Disinfection
- Water Quality Monitoring Technologies
- Fish Ecology and Management Studies
- Biofuel production and bioconversion
- Isotope Analysis in Ecology
- Circular RNAs in diseases
- Pesticide and Herbicide Environmental Studies
- Groundwater and Isotope Geochemistry
- Pesticide Residue Analysis and Safety
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Advanced Chemical Sensor Technologies
- Aquaculture disease management and microbiota
- Groundwater flow and contamination studies
- Mercury impact and mitigation studies
- Reproductive biology and impacts on aquatic species
- MicroRNA in disease regulation
- Enzyme-mediated dye degradation
Northwest A&F University
2024
Southern California Coastal Water Research Project
2018-2023
Qilu University of Technology
2023
Nanjing General Hospital of Nanjing Military Command
2020-2022
Nanjing Medical University
2022
Nanjing University
2020-2021
Baylor University
2010-2017
Aquatic Systems (United States)
2012-2017
Center for Urban Waters
2017
University of Washington Tacoma
2017
In U.S. Pacific Northwest coho salmon (
Urban stormwater is a major threat to ecological health, causing range of adverse, mostly sublethal effects. In western North America, urban runoff acutely lethal adult coho salmon ( Oncorhynchus kisutch) that spawn each fall in freshwater creeks. Although the mortality syndrome correlated urbanization and attributed road contaminant(s), causal agent(s) remain unknown. We applied high-resolution mass spectrometry isolate chemical signature: list nontarget identified features co-occurred...
A variety of potentially inhibitory degradation products are produced during pretreatment lignocellulosic biomass. Qualitative and quantitative interrogation hydrolysates is paramount to identifying potential correlations between chemistries microbial inhibition in downstream bioconversion processes. In the present study, corn stover, poplar, pine feedstocks were pretreated under eight different chemical conditions, which representative leading Pretreatment processes included: 0.7%...
microRNAs play an important roles in cell growth, differentiation, proliferation and apoptosis. They can function either as tumor suppressors or oncogenes. We found that the overexpression of miR-192 inhibited A549, H460 95D cells, tumorigenesis a nude mouse model. Both caspase-7 PARP protein were activated by miR-192, thus suggesting induces apoptosis through caspase pathway. Further studies showed retinoblastoma 1 (RB1) is direct target miR-192. Over-expression decreased RB1 mRNA levels...
Though pharmaceuticals are increasingly observed in a variety of organisms from coastal and inland aquatic systems, trophic transfer food webs have not been reported. In this study, bioaccumulation select was investigated lower order effluent-dependent stream central Texas, USA, using isotope dilution liquid chromatography-tandem mass spectrometry (MS). A fish plasma model, initially developed laboratory studies, tested to examine versus predicted internal dose pharmaceuticals....
German Environment Specimen Bank (GESB) fish tissue samples, collected from 14 different GESB locations, were analyzed for 15 pharmaceuticals, 2 pharmaceutical metabolites, and 12 personal care products. Only diphenhydramine desmethylsertraline, measured above MDL. Diphenhydramine (0.04-0.07 ng g(-1) ww) desmethylsertraline (1.65-3.28 at 4 respectively. The maximum concentrations of galaxolide (HHCB) (447 tonalide (AHTN) (15 the Rehlingen sampling site in Saar River. A significant decrease...
In recent years pharmaceuticals have been detected in aquatic systems receiving discharges of municipal and industrial effluents. Although diphenhydramine (DPH) has reported water, sediment, fish tissue, an understanding its impacts on organisms is lacking. Diphenhydramine multiple modes action (MOA) targeting the histamine H1, acetylcholine (ACh), 5-HT reuptake transporter receptors, as such used hundreds pharmaceutical formulations. The primary objective this study was to develop a...
Abstract The occurrence of pharmaceuticals in the environment presents a challenge growing concern. In contrast to many industrial compounds, undergo extensive testing prior their introduction environment. principle, therefore, it may be possible employ existing pharmacological safety data using biological “read‐across” methods support screening‐level bioaccumulation environmental risk assessment. However, few approaches and robust empirical sets exist, particularly for comparative...
Processing of paired water and tissue samples facilitated contaminant prioritization aided investigation chemical bioavailability uptake processes.
A need exists to better understand the influence of pH on uptake and accumulation ionizable pharmaceuticals in fish. In present study, fathead minnows were exposed diphenhydramine (DPH; disassociation constant = 9.1) water for up 96 h at 3 nominal levels: 6.7, 7.7, 8.7. each case, an apparent steady state was reached by 24 h, allowing direct determination bioconcentration factor (BCF), blood-water partitioning (PBW,TOT), volume distribution (approximated from whole-body-plasma concentration...
Non-targeted analysis (NTA) encompasses a rapidly evolving set of mass spectrometry techniques aimed at characterizing the chemical composition complex samples, identifying unknown compounds, and/or classifying without prior knowledge regarding content samples. Recent advances in NTA are result improved and more accessible instrumentation for data generation tools evaluation interpretation. As researchers continue to develop approaches various scientific fields, there is growing need...
Though pharmaceuticals and other contaminants of emerging concern are increasingly observed in inland water bodies, the occurrence bioaccumulation estuaries coastal ecosystems poorly understood. In present study, select was examined fish from Buffalo Bayou, a tidally influenced urban ecosystem that receives effluent major (∼200 million gallons per day) municipal wastewater treatment plant Houston, Texas, USA. Using isotope dilution liquid chromatography-tandem mass spectrometry, various...
Abstract Background Tumorigenic phenotype of M2 tumor-associated macrophages promote tumor progression in response to exosomes cues imposed by cells. However, the effect and underlying mechanisms clear cell renal carcinoma (ccRCC)-derived (ccRCC-exo) on instructing remains unclear. Methods Macrophages were cocultured with ccRCC-exo then evaluate polarization migration ccRCC The mechanism lncRNA AP000439.2 overexpressed or deleted examined. Xenograft mice model was used for vivo validation....
Abstract Over the last decade, more than 10 independent SNPs have been discovered to be associated with risk of renal cell carcinoma among different populations. However, biological functions them remain poorly understood. In this study, we performed eQTL analysis, ChIP-PCR, luciferase reporter assay, and Cox regression analysis identify functional role underlying mechanism rs67311347 in RCC. The ENCORI database, which contains lncRNA–miRNA–mRNA interactions, was used explore possible target...
The osprey (Pandion haliaetus) is a well-known sentinel of environmental contamination, yet no studies have traced pharmaceuticals through the water-fish-osprey food web. A screening-level exposure assessment was used to evaluate bioaccumulation potential 113 and metabolites, an artificial sweetener in this Hypothetical concentrations water reflecting "wastewater effluent dominated" or "dilution scenarios were combined with pH-specific bioconcentration factors (BCFs) predict uptake fish....
Abstract Instream flows of the rapidly urbanizing watersheds and estuaries Gulf Mexico in Texas (USA) are increasingly dominated by reclaimed waters. Though ionizable pharmaceuticals have received increasing attention freshwaters, many research questions remain unanswered, particularly tidally influenced urban coastal systems, which experience significant spatiotemporal variability pH that influences bioavailability bioaccumulation. The authors coupled fish plasma modeling therapeutic hazard...
Diffuse pollution in urban receiving waters often adversely impacts both humans and ecosystems. Identifying such sources is challenging limits the effectiveness of management actions intended to reduce risk. Here, we evaluated use nontarget analysis via high-resolution mass spectrometry (HRMS) develop chemical fingerprints/signatures for source tracking. Specifically, applied HRMS characterize differentiate two sources: roadway runoff wastewater influent. We isolated 112 598 compounds (both...