A5009104622- RNA modifications and cancer
- Metal-Catalyzed Oxygenation Mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Metal complexes synthesis and properties
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- DNA Repair Mechanisms
- Colorectal Cancer Treatments and Studies
- Fibroblast Growth Factor Research
- Cancer Treatment and Pharmacology
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Histone Deacetylase Inhibitors Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Kruppel-like factors research
Taipei Medical University
2016-2025
Tzu Chi University
2022-2025
Taipei Municipal YangMing Hospital
2015-2024
Wan Fang Hospital
2019-2024
City Of Hope National Medical Center
2010-2023
California Institute of Technology
2005-2021
Academia Sinica
2016-2021
Taichung Veterans General Hospital
2020-2021
City of Hope
2010-2020
National Cancer Center
2007-2019
Abstract Farnesoid X receptor (FXR, NR1H4) is a member of the nuclear hormone superfamily, which plays an essential role in regulating bile acid, lipid, and glucose homeostasis. Both male female FXR−/− mice spontaneously developed liver tumors; however, no other tumors were after 15 months age. In contrast, observed wild-type same Histologic analyses confirm that hepatocellular adenoma carcinoma. Although there was obvious tumor at ages 9 to 12 months, livers displayed prominent injury...
Significance CALAA-01 is a targeted nanoparticle containing siRNA that first-in-class experimental therapeutic for cancer. To our knowledge, it the first targeted, polymer-based nanoparticle-carrying to be systemically administered humans. Results from human phase Ia/Ib clinical trial are presented and correlated preclinical animal data provide an initial assessment of how this class therapeutics translated animals
Hepatocellular carcinoma (HCC) is a common malignancy in the world with high morbidity and mortality rate. Identification of novel biomarkers HCC remains impeded primarily because heterogeneity disease clinical presentations as well pathophysiological variations derived from underlying conditions such cirrhosis steatohepatitis. The aim this study to search for potential metabolite human using serum urine metabolomics approach. Sera samples were collected patients (n = 82), benign liver tumor...
Breast cancer is genetically and clinically heterogeneous. Triple negative breast (TNBC) a subtype of that usually associated with poor outcome lack benefit from targeted therapy. We used microarray analysis to perform pathway TNBC compared non-triple (non-TNBC). Overexpression several Wnt genes, such as frizzled homolog 7 (FZD7), low density lipoprotein receptor-related protein 6 transcription factor (TCF7) was observed in TNBC, we directed our focus the receptor, FZD7. To validate function...
Abstract Purpose: The new classification announced by the World Health Organization in 2016 recognized five molecular subtypes of diffuse gliomas based on isocitrate dehydrogenase (IDH) and 1p/19q genotypes addition to histologic phenotypes. We aim determine whether clinical MRI can stratify these benefit diagnosis monitoring gliomas. Experimental Design: data from 456 subjects with were obtained Cancer Imaging Archive. Overall, 214 subjects, including 106 cases glioblastomas 108 lower grade...
Abstract Background MicroRNAs (miRNAs) have been recently detected in the circulation of cancer patients, where they are associated with clinical parameters. Discovery profiling circulating small RNAs has not reported breast (BC), and was carried out this study to identify blood-based RNA markers BC outcome. Methods The pre-treatment sera 42 stage II-III locally advanced inflammatory patients who received neoadjuvant chemotherapy (NCT) followed by surgical tumor resection were analyzed for...
Abstract Long noncoding RNAs (lncRNAs) have been implicated in hypoxia/HIF-1-associated cancer progression through largely unknown mechanisms. Here we identify MIR31HG as a hypoxia-inducible lncRNA and therefore name it LncHIFCAR (long HIF-1α co-activating RNA); describe its oncogenic role co-activator that regulates the HIF-1 transcriptional network, crucial for development. Extensive analyses of clinical data indicate level is substantially upregulated oral carcinoma, significantly...
Mesoporous silica nanoparticles (MSNs) represent a promising avenue for targeted brain tumor therapy. However, the blood–brain barrier (BBB) often presents formidable obstacle to efficient drug delivery. This study introduces ligand-free PEGylated MSN variant (RMSN25-PEG-TA) with 25 nm size and slight positive charge, which exhibits superior BBB penetration. Utilizing two-photon imaging, RMSN25-PEG-TA particles remained in circulation over 24 h, indicating significant traversal beyond...
Pancreatobiliary and ampulla of Vater adenocarcinomas frequently metastasize to regional lymph nodes, liver, or lung are difficult diagnose because they lack specific immunohistochemical markers. We studied the expression cytokeratin 7 (CK7), 17 (CK17), 20 (CK20), CDX2, mucin 1 (MUC1), 2 (MUC2), 5AC (MUC5AC) in 46 cases pancreatic ductal carcinoma, 18 adenocarcinomas, 24 intrahepatic cholangiocarcinomas. The MUC1 CK17 was restricted carcinoma (41 46, 89%; 38 83%, respectively), ampullary...
This study aims to address the hypothesis that high-mobility group A2 (HMGA2), an oncofetal protein, relates survivability and serves as a prognostic biomarker for colorectal cancer (CRC).This is retroprospective multiple center study. The HMGA2 expression level was determined by performing immunohistochemistry on surgical tissue samples of 89 CRCs from training set 191 validation set. Kaplan-Meier analysis COX proportional hazard model were employed analyze survivability.Multivariate...
Tumors that cannot make arginine undergo mitochondrial dysfunction in the absence of extracellular and die by autophagy.
Nanoparticle-based therapeutics are being used to treat patients with solid tumors. Whereas nanoparticles have been shown preferentially accumulate in tumors of animal models, there is little evidence prove that intact localize humans when systemically administered. Here, tumor and adjacent, nonneoplastic tissue biopsies obtained through endoscopic capture from gastric, gastroesophageal, or esophageal cancer who administered the nanoparticle CRLX101. Both pre- postdosing samples adjacent...
As a multifunctional protein, KRAB domain-associated protein 1 (KAP1) is reportedly subjected to multiple posttranslational modifications, including phosphorylation and sumoylation. However, gaps exist in our knowledge of how KAP1 cross-talks with sumoylation what the biological consequence is. Here, we show that doxorubicin (Dox) treatment induces at Ser-824 via an ataxia telangiectasia mutated (ATM)-dependent manner, correlating transcriptional de-repression p21WAF1/CIP1 Gadd45alpha. A...
Abstract Purpose: Metabolic phenotyping has provided important biomarker findings, which, unfortunately, are rarely replicated across different sample sets due to the variations from analytical and clinical protocols used in studies. To date, very few metabolic hallmarks a given cancer type have been confirmed validated by use of metabolomic approach other modalities. Here, we report metabolomics study identify potential metabolite biomarkers colorectal with theranostic value. Experimental...