A5101542614- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Advanced Radiotherapy Techniques
- Diet and metabolism studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
Fudan University Shanghai Cancer Center
2015-2025
Shanghai Medical College of Fudan University
2014-2025
Second Affiliated Hospital of Nanjing Medical University
2025
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2024
Xuzhou Medical College
2023
Burning Rock Biotech (China)
2023
Third Affiliated Hospital of Southern Medical University
2021
Fudan University
2008-2020
Color (United States)
2018-2019
Abstract Background Mounting evidence has demonstrated the vital importance of tumor-associated macrophages (TAMs) and exosomes in formation premetastatic niche. However, molecular mechanisms by which tumor-derived exosomal miRNAs interact with TAMs underlying niche colorectal cancer liver metastasis (CRLM) remain largely unknown. Methods Transmission electron microscopy differential ultracentrifugation were used to verify existence exosomes. In vivo vitro assays identify roles miR-934. RNA...
Purpose: Colorectal cancer is one of the most common malignancies worldwide. Recently, a novel circular RNA, ciRS-7, was proposed to be potential miR-7 sponge. As miR-7, putative tumor-suppressor, regulates expression several important drivers colorectal cancer, we analyzed clinical significance ciRS-7 in patients.Experimental Design: Initially, evaluated levels training cohort comprising 153 primary tissues and 44 matched normal mucosae. We subsequently confirmed its relevance an...
Colorectal carcinogenesis involves the overexpression of many immediate-early response genes associated with growth and inflammation, which significantly alters downstream protein synthesis small-molecule metabolite production. We have performed a serum metabolic analysis to test hypothesis that distinct profiles malignant tumors are reflected in biofluids. In this study, we analyzed metabolites from 64 colorectal cancer (CRC) patients 65 healthy controls using gas chromatography...
Colorectal cancer (CRC) is 3rd most commonly diagnosed in males and the second females. PD-1/PD-L1 axis, as an immune checkpoint, up-regulated many tumors their microenvironment. However, prognostic value of CRC remains unclear.The Cancer Genome Atlas (TCGA) database (N = 356) Fudan University Shanghai Center (FUSCC) cohort patients 276) were adopted to analyze PD-L1 colorectal tumor cells (TCs) PD-1 infiltrating (TILs) for CRC. Subgroup analyses conducted FUSCC according patients' status...
Rationale: Colorectal cancer (CRC) is a malignant tumor with the third highest morbidity rate among all cancers. Driven by host's genetic makeup and environmental exposures, gut microbiome its metabolites have been implicated as causes regulators of CRC pathogenesis. We assessed human fecal samples noninvasive unbiased surrogates to catalog microbiota metabolome in patients CRC. Methods: Fecal collected from (CRC group, n = 50) healthy volunteers (H were subjected (16S rRNA gene sequencing)...
Emerging evidence suggests a potential relationship between gut microbiota and the host response to chemotherapeutic drugs including 5-fluorouracil (5-Fu). Fusobacterium nucleatum (Fn) has been linked initiation progression of colorectal cancer (CRC). Unfortunately, little was known about Fn infection efficacy. Here, we investigate efficacy 5-Fu in CRC.Differentially expressed genes CRC cell lines induced by were analyzed based on whole genome microarray analysis Then, explored upregulation...
Abstract Liver metastasis of colorectal cancer (CRLM) is the most common cause CRC‐related mortality, and typically caused by interactions between CRC cells tumour microenvironment (TME) in liver. However, molecular mechanisms underlying crosstalk tumour‐derived extracellular vesicle (EV) miRNAs TME CRLM have yet to be fully elucidated. The present study demonstrated that highly metastatic released more miR‐181a‐5p‐rich EVs than which exhibit a low potential, in‐turn promoting CRLM....
Precise methods for postoperative risk stratification to guide the administration of adjuvant chemotherapy (ACT) in localized colorectal cancer (CRC) are still lacking. Here, we conducted a prospective, observational, and multicenter study investigate utility circulating tumor DNA (ctDNA) predicting recurrence risk.
For locally advanced rectal cancer (LARC) patients who receive neoadjuvant chemoradiotherapy (nCRT), there are no reliable indicators to accurately predict pathological complete response (pCR) before surgery. with clinical (cCR), a "Watch and Wait" (W&W) approach can be adopted improve quality of life. However, W&W may increase the recurrence risk in judged cCR but have minimal residual disease (MRD). Magnetic resonance imaging (MRI) is major tool evaluate nCRT; however, its ability pCR...
Abstract There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient‐derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM organoids derived from primary tumors paired metastatic lesions successfully constructed. PDOs the multiomics levels (histopathology, genome, transcriptome single‐cell sequencing) are comprehensively analyzed confirmed that this...
Detection of molecular residual disease and risk stratification as early possible may improve the treatment patients with cancer. Efficient pragmatic tests are therefore required.
Recent studies suggest that biofluid-based metabonomics may identify metabolite markers promising for colorectal cancer (CRC) diagnosis. We report here a follow-up replication study, after previous CRC aiming to distinct serum metabolic signature of with diagnostic potential. Serum metabolites from newly diagnosed patients (N = 101) and healthy subjects 102) were profiled using gas chromatography time-of-flight mass spectrometry (GC-TOFMS) ultraperformance liquid quadrupole (UPLC-QTOFMS)....
Abstract Purpose: Metabolic phenotyping has provided important biomarker findings, which, unfortunately, are rarely replicated across different sample sets due to the variations from analytical and clinical protocols used in studies. To date, very few metabolic hallmarks a given cancer type have been confirmed validated by use of metabolomic approach other modalities. Here, we report metabolomics study identify potential metabolite biomarkers colorectal with theranostic value. Experimental...
Increasing evidence indicates that inflammation plays a vital role in tumorigenesis and progression. However, the prognostic value of inflammatory biomarkers colorectal cancer (CRC) has not been established. In this study, retrospective analysis was conducted patients with CRC Fudan University Shanghai Cancer Center (FUSCC) between April 1, 2007 30, 2014, 5,336 were identified eligible. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR),...
ObjectiveCurrent non-invasive early detection of colorectal cancer (CRC) requires improvement. We aimed to identified a fecal Clostridium symbiosum-based biomarker for and advanced detection.DesignIn the test stage, relative abundance symbiosum (C. symbiosum) was measured by qPCR in 781 cases including 242 controls, 212 adenoma (CRA) patients, 109 CRC (tumor restricted submucosa) 218 patients. The prediction accuracy compared Fusobacterium nucleatum (F. nucleatum), immunochemical (FIT) CEA...
Differentiating the irinotecan dose on basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotype improves pathologic complete response (pCR) rate. In this study, we further investigated preoperative combined with capecitabine-based chemoradiotherapy for locally advanced rectal cancer.We conducted randomized, open-label, multicenter, phase III trial in China. Eligible patients clinical T3-4 and/or N+ adenocarcinoma, UGT1A1 *1*1 or *1*28 were randomly allocated to control...
Background: The oral microbiome may play an important role in colorectal carcinogenesis. However, few studies have investigated the association between and development of cancer (CRC). We aimed to investigate whether health-colorectal tumor has underlying microbial basis, quest for novel non-invasive biomarkers CRC. Methods: collected swab samples from 161 patients with CRC, 34 adenoma (CRA), 58 healthy volunteers. microbiota was assessed using 16S rRNA sequencing. characterized microbiome,...
Introduction: Most advanced colorectal cancers are aggressive, and there is a lack of effective methods for selecting appropriate anticancer regimens. Patient-derived organoids (PDOs) have emerged as preclinical platforms modeling clinical responses to cancer therapy. Methods: In this study, we successfully constructed living biobank with 42 derived from primary metastatic lesions patients. Tumor tissue was obtained patients undergoing surgical resection the or lesion then used establish...
We have previously demonstrated an aberrant overexpression of the microtubule-associated protein TPX2 in colon cancer using a genome-wide gene expression profiling analysis. Here, we aim to investigate its pattern, clinical significance, and biological function cancer. was analyzed human cell lines tumor samples. The effect on proliferation, tumorigenesis, metastasis examined vitro vivo. overexpressed 129 203 (60.8%) metastatic lesions, with being significantly higher than that primary...
Mutations of KRAS , NRAS BRAF and DNA mismatch repair (MMR) status have become an important part the assessment patients with colorectal cancer (CRC), while respective clinicopathologic features prognostic significance in specific stages related detection strategies remain unclear. We retrospectively analyzed prognosis 1,834 Stage I–IV adenocarcinoma. MMR were determined. The mutation rates 46.4, 3.2 3.5%, respectively, gene deletion (dMMR) rate was 5.6%. In a multivariate analysis, female,...
Long noncoding RNAs (lncRNAs) have recently emerged as a major class of regulatory molecules, which were involved in broad range biological processes and complex diseases. Research on lncRNAs may shed light tumorigenesis progression colorectal cancer (CRC). The purpose the present study was to identify correlated with CRC then investigate their potential functions. We selected 92 patients for this prospective collected tumor samples clinical records. First, global lncRNA expression profiles...