A5073528165- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Medical Imaging and Pathology Studies
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Esophageal Cancer Research and Treatment
- Peptidase Inhibition and Analysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Abdominal Trauma and Injuries
- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Hormonal and reproductive studies
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genomics and Chromatin Dynamics
Fudan University Shanghai Cancer Center
2018-2025
Fudan University
2021-2024
Shanghai Medical College of Fudan University
2018-2024
The University of Texas at Arlington
2024
Research Institute of Petroleum Exploration and Development
2024
Qilu Hospital of Shandong University
2023
Dalian Medical University
2022
Second Affiliated Hospital of Dalian Medical University
2022
Southeast University
2018
Hainan Medical College Hospital
2007
Abstract Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic immune profiles these lesions poorly understood. Here we report exome transcriptome sequencing 98 precursor 99 adenocarcinomas. We have identified EGFR , RBM10 BRAF ERBB2 TP53 KRAS MAP2K1 MET as significantly mutated genes pre/minimally group. Classes genome alterations that increase frequency during progression to malignancy revealed. These include mutations...
Abstract There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient‐derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM organoids derived from primary tumors paired metastatic lesions successfully constructed. PDOs the multiomics levels (histopathology, genome, transcriptome single‐cell sequencing) are comprehensively analyzed confirmed that this...
Esophageal squamous cell cancer (ESCC) patients with the potentially resectable disease most would experience relapse after surgery. Immunotherapy has been reported to improve prognosis of advanced esophageal and may be a new strategy prevent this urgent condition's recurrence. We first evaluated efficacy safety neoadjuvant chemotherapy combined immunotherapy in ESCC.All locally ESCC (clinical stage III-IVB). Received at least 1 cycle (NACI), interval between each operation should 3 weeks....
We aimed to prospectively evaluate our previously proposed selective mediastinal lymph node (LN) dissection strategy for peripheral clinical T1N0 invasive NSCLC.This is a multicenter, prospective trial in China. set six criteria predicting negative LN stations and finally guiding dissection. Consolidation tumor ratio less than or equal 0.5, segment location, lepidic-predominant adenocarcinoma (LPA), hilar nodes (stations 10-12), visceral pleural invasion (VPI) were used separately...
Lung adenocarcinoma follows a stepwise progression from pre-invasive to invasive. However, there remains knowledge gap regarding molecular events Here, we conduct comprehensive proteogenomic analysis comprising whole-exon sequencing, RNA and proteomic phosphoproteomic profiling on 98 99 invasive lung adenocarcinomas. The deletion of chr4q12 contributes the by downregulating SPATA18, thus suppressing mitophagy promoting cell invasion. Proteomics reveals diverse enriched pathways in normal...
Background: The tumor microenvironment (TME) plays an important role in progression and immunotherapy responses non-small cell lung cancer (NSCLC). programmed death 1 (PD-1)/ death-ligand (PD-L1) checkpoint is a central mediator of immunosuppression the TME. However, there still need to identify additional biomarkers that could reflect difference TME PD-L1 expression NSCLC patients. To this end, we focused on G-protein-coupled receptor family C group 5 type A (GPRC5A) NSCLC. GPRC5A, retinoic...
This study aims to investigate the imaging features of epidermoid cysts within intrapancreatic accessory spleen (ECIPAS) benefit differential diagnosis pancreatic cystic lesions. We retrospectively reviewed clinical, radiological and pathological data 24 patients with pathologically confirmed ECIPAS. All cases underwent abdominal contrast-enhanced computed tomography (CE-CT) scans, 4 further undergoing magnetic resonance cholangiopancreatography (MRCP). The lesions were analyzed. majority...
Programmed death ligand-1 (PD-L1) is a predictive marker of anti-programmed protein 1 (PD-1)/PD-L1 therapies for non-small cell lung cancer (NSCLC). However, little known between PD-L1 expression and the clinicopathological characteristics NSCLC in Chinese population real-world setting.
Programmed cell death ligend-1 (PD-L1) expression by immunohistochemistry (IHC) assays is a predictive marker of anti-PD-1/PD-L1 therapy response. With the popularity inhibitor drugs, quantitative assessment PD-L1 becomes new labor for pathologists. Manually counting positive stained tumor cells an obviously subjective and time-consuming process. In this paper, we developed computer aided Automated Tumor Proportion Scoring System (ATPSS) to determine comparability image analysis with...
Abstract Background Lung adenocarcinoma (LUAD) is a highly malignant and heterogeneous tumor that involves various oncogenic genetic alterations. Epigenetic processes play important roles in lung cancer development. However, the variation enhancer super-enhancer landscapes of LUAD patients remains largely unknown. To provide an in-depth understanding epigenomic heterogeneity LUAD, we investigate H3K27ac histone modification profiles tumors adjacent normal tissues from 42 explore role...
Objective: To investigate the value of intraoperative assessment spread through air spaces (STAS) on frozen sections (FS) in peripheral small-sized lung adenocarcinoma. Background: Surgical decision-making based FS diagnosis STAS may be useful to prevent local control failure after sublobar resection. Methods: We conducted a multicenter prospective observational study consecutive patients with cT1N0M0 invasive adenocarcinoma evaluate accuracy for detection STAS. The final pathology (FP) was...
POU2F3 (POU class 2 homeobox 3) is a novel transcription factor used to define the special molecular subtype of small cell lung cancer (SCLC) known as SCLC-P. Nevertheless, sensitivity and specificity immunohistochemical (IHC) staining have not been fully investigated. In this study, we explored expression by IHC in large cohort SCLC clinical samples (n=246), other common types (n=2207), various (n=194). The results showed that was strongly nuclear stained 13.41% (33/246) cases, with...
Currently, programmed death ligand-1 (PD-L1) expression has been widely applied in clinical trials and real-world practice as a major biomarker for the efficacy of immune-checkpoint inhibitors. The purpose this study is to reveal distribution concordance PD-L1 large-scale consecutive cohort from East-Asian patients with non-small cell lung cancer (NSCLC).PD-L1 testing was conducted using 22C3 assays, cases were categorized into high, low, no based on tumor proportion score (TPS)....
Abstract Objective Binding of 18 F-DCFPyL at prostate cancer (PC) cells increases over time. The dual-phase protocol may be helpful in separating benign lesions from malignant ones associated with cancer. purpose this study was to retrospectively analyze the incremental diagnostic value dual-time imaging patients Method 114 prostate-related and 43 38 were analyzed. Maximum standardized uptake (SUVmax) for calculated min 60 120 PET/CT imaging. In order calculate SUV ratio, SUVmax left gluteus...
Complex glandular pattern (CGP) was included as high-grade in the new grading system proposed by The International Association for Study of Lung Cancer. We aimed to investigate mutational profile and validate prognostic significance proper cut-off value distinguish aggressive behavior CGP.CGP defined nests tumor cells with sieve-like perforation, fused glands irregular borders or back-to-back without intervening stroma. Patients were categorized into four groups according percentage CGP...
Abstract Background Neoadjuvant therapy followed by surgery has become the standard of care for locally advanced esophageal squamous cell carcinoma (ESCC) and accurate pathological response assessment is critical to assess therapeutic efficacy. However, it can be laborious inconsistency between different observers may occur. Hence, we aim develop an interpretable deep-learning model efficient following neoadjuvant in ESCC. Methods This retrospective study analyzed 337 ESCC resection...