A5049791989- Hip and Femur Fractures
- Bone fractures and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Pelvic and Acetabular Injuries
- Spinal Fractures and Fixation Techniques
- Orthopaedic implants and arthroplasty
- Cardiac, Anesthesia and Surgical Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Pancreatic and Hepatic Oncology Research
- Neurosurgical Procedures and Complications
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Metal complexes synthesis and properties
- Advanced X-ray and CT Imaging
- S100 Proteins and Annexins
- Cancer Immunotherapy and Biomarkers
- Pancreatitis Pathology and Treatment
- Trauma and Emergency Care Studies
- Neuroendocrine Tumor Research Advances
- Hepatitis B Virus Studies
- Estrogen and related hormone effects
- Glaucoma and retinal disorders
- Lower Extremity Biomechanics and Pathologies
- Orthopedic Surgery and Rehabilitation
Peking University
2014-2025
Peking University Third Hospital
2014-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2009-2025
Hunan Children's Hospital
2012-2024
Zhejiang Chinese Medical University
2023-2024
Qingdao University
2024
Henan University of Urban Construction
2021-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Abstract Platinum complexes are potential antitumor drugs in chemotherapy. Their impact on tumor treatment could be greatly strengthened by combining with immunotherapy. Increasing evidences indicate that the activity of platinum is not limited to chemical killing effects, but also extends immunomodulatory actions. This review introduced general concept chemoimmunotherapy and summarized progress as chemoimmunotherapeutic agents recent years. developed into inducers immunogenic cell death,...
Metastasis, the leading cause of cancer death, requires tumor cell intravasation, migration through bloodstream, arrest within capillaries, and extravasation to invade distant tissues. Few mechanistic details have been reported thus far regarding process or re-entry circulating cells at metastatic sites. Here, we show that neuropilin-2 (NRP-2), a multifunctional nonkinase receptor for semaphorins, vascular endothelial growth factor (VEGF), other factors, expressed on interacts with α5...
Although the modified tension band technique (eg, supplemented by longitudinal Kirschner wires) has long been mainstay for fixation of transverse fractures patella, it shortcomings, such as bad reduction, loosening implants, and skin irritation.We conducted a retrospective comparison titanium cable-cannulated screw technique.We retrospectively reviewed 101 patients aged 22 to 85 years (mean, 56.6 years) with AO/OTA 34-C1 (n = 68) 34-C2 33). Fifty-two were in group 49 group. Followup was at...
Previous studies have demonstrated that patients with traumatic brain injury (TBI) who also progressive hemorrhagic (PHI), a higher risk of clinical deterioration and worse outcomes than do TBI without PHI. Therefore, the early prediction PHI occurrence is useful to evaluate status improve outcomes. The objective this study was develop validate prognostic model uses information available at admission determine likelihood after TBI. Retrospectively collected data were used logistic regression...
Abstract Background The incidence of intertrochanteric hip fracture is expected to increase as the global population ages. It one most important causes mortality and morbidities in geriatric population. reverse oblique transverse (AO/OTA 31-A3) fractures relatively low; however, implant failure AO/OTA 31-A3 high compared with that 31-A1 A2 fractures. To date, risk factors for treated proximal femoral nail antirotation (PFNA) have remained ambiguous. purpose this study was identify predictive...
Solid-pseudopapillary neoplasm of the pancreas is a rare tumor uncertain histogenesis that characterized by cystic and solid growth pattern with pseudopapillary structures. The differentiation solid-pseudopapillary from other pancreatic tumors great importance. However, it sometimes difficult because similarities in morphologic features immunophenotype. CD99 diagnostically useful marker for Ewing sarcoma/primitive neuroectodermal tumor. aim this study was to investigate diagnostic value...
Progressive epidural hematoma (PEDH) after head injury is often observed on serial computerized tomography (CT) scans. Recent advances in imaging modalities and treatment might affect its incidence outcome. In this study, PEDH was 9.2% of 412 trauma patients whom two CT scans were obtained within 24 hours injury, a majority cases, it developed 3 days injury. multivariate logistic regression, patient gender, age, Glasgow Coma Scale (GCS) score at admission, skull fracture not associated with...
Cancer is characterized by abnormal cellular energy metabolism, which preferentially switches to aerobic glycolysis rather than oxidative phosphorylation as a means of glucose metabolism. Many key enzymes involved in the are potential targets anticancer drugs. Platinum(IV) complexes prodrugs and kinetically more inert platinum(II) counterparts, offer an opportunity be modified functional ligands for activation or targeted delivery. A novel platinum(IV) complex,...
To construct diagnostic models that distinguish renal oncocytoma (RO) from chromophobe cell carcinoma (CRCC) using intratumoral and peritumoral radiomic features the corticomedullary phase (CMP) nephrographic (NP) of computed tomography, compare model results with manual radiological results. The RO CRCC cases five centers were split into a training set (70%) validation (30%). CMP NP (1-3 mm) extracted. Segmentation was performed by radiologists software. Features high intraclass correlation...
To determine risk factors for cutout failure in geriatric intertrochanteric fracture patients after cephalomedullary nail fixation. A retrospective review of 518 elderly who underwent fixation fractures between January 2008 and August 2018 was conducted, including 167 males 351 females, age from 65 to 97 years old. All were followed up at least one year surgery divided into a healed group based on whether the hip screw occurred. Among all patients, 10 cases experienced cutout. The general...
Background: The risk factors for thyroiditis, an inflammatory disease with a complex etiology, remain poorly understood. Blood metabolites are known to change during thyroiditis development, suggesting close relationship between blood and progression. However, evidence causal link is lacking. We employed Mendelian randomization (MR) methodology systematically investigate the putative relationships metabolite profiles two clinically distinct phenotypes—subacute autoimmune...
Early estimation of prognosis for the patient with traumatic brain injury is an important factor in making treatment decisions, resource allocation, classify patients, or communicating family. We aimed to develop and validate practical prognostic models mortality at 30 days 6 months unfavorable outcome after moderate severe injury.Retrospectively collected data from our department were used outcome. developed four based on admission predictors logistic regression analysis. The performance...
Estrogen sulfotransferase (EST) regulates estrogen homeostasis by sulfonating and deactivating estrogens. Liver ischemia reperfusion (I/R) involves both hypoxia during the ischemic phase oxidative damage phase. In this report, we showed that expression of EST was markedly induced I/R. Mechanistically, stress-induced activation Nrf2 responsible for induction, which abolished in Nrf2(-/-) mice. is a direct transcriptional target Nrf2. female mice, I/R-responsive induction compromised activity....
Mitochondrial DNA (mtDNA) is an attractive cellular target for anticancer agents in addition to nuclear (nDNA). The cationic platinum(II) complex cis-[Pt(NP)(NH3)2Cl]NO3 (PtNP, NP = N-(2-ethylpyridine)-1,8-naphthalimide) bearing the DNA-intercalating moiety was designed. structure of PtNP fully characterized by single-crystal X-ray crystallography, NMR, and HRMS. superior cisplatin both vitro vivo activities with low systemic toxicity. interaction CT-DNA demonstrated that could effectively...
Plant sterol ester of α-linolenic acid prevents nonalcoholic fatty liver disease by improving mitochondrial function, modifying lipid metabolism, and inhibiting oxidative stress <italic>via</italic> AMPK signaling.
Programmed cell death ligend-1 (PD-L1) expression by immunohistochemistry (IHC) assays is a predictive marker of anti-PD-1/PD-L1 therapy response. With the popularity inhibitor drugs, quantitative assessment PD-L1 becomes new labor for pathologists. Manually counting positive stained tumor cells an obviously subjective and time-consuming process. In this paper, we developed computer aided Automated Tumor Proportion Scoring System (ATPSS) to determine comparability image analysis with...