A5101486064- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Catalytic C–H Functionalization Methods
- Intracerebral and Subarachnoid Hemorrhage Research
- Nanoplatforms for cancer theranostics
- Synthesis and Catalytic Reactions
- Neurosurgical Procedures and Complications
- Cancer-related molecular mechanisms research
- Gallbladder and Bile Duct Disorders
- Trauma and Emergency Care Studies
- Marine Bivalve and Aquaculture Studies
- Sulfur-Based Synthesis Techniques
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Synthesis of Organic Compounds
- Neurological Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Proteins in Food Systems
- Lipid metabolism and disorders
- Polysaccharides Composition and Applications
- Forest, Soil, and Plant Ecology in China
- Polysaccharides and Plant Cell Walls
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
Shanghai Sixth People's Hospital
2012-2023
Shanghai Jiao Tong University
2014-2023
Chongqing Medical University
2021-2023
Southwest Hospital
2023
Army Medical University
2023
Army Medical College
2023
Shanghai University of Traditional Chinese Medicine
2016-2022
Second Military Medical University
2022
Bridge University
2022
Ministry of Agriculture and Rural Affairs
2022
Abstract Background Microglia-mediated neuroinflammatory response following traumatic brain injury (TBI) is considered as a vital secondary factor, which drives trauma-induced neurodegeneration and lack of efficient treatment. ACT001, sesquiterpene lactone derivative, reportedly involved in alleviation inflammatory response. However, little known regarding its function regulating innate immune central nervous system (CNS) after TBI. This study aimed to investigate the role underlying...
Abstract Sirtuin 2 ( SIRT 2) is a member of the sirtuin family NAD + ‐dependent protein deacetylases. In recent years, inhibition has emerged as promising treatment for neurodegenerative diseases. However, to date, there no evidence specific role in traumatic brain injury TBI ). We investigated effects on experimental using controlled cortical impact CCI ) model. Adult male mice underwent or sham surgery. A selective brain‐permeable inhibitor, AK ‐7, was administrated 30 min before injury....
Previous studies have demonstrated that patients with traumatic brain injury (TBI) who also progressive hemorrhagic (PHI), a higher risk of clinical deterioration and worse outcomes than do TBI without PHI. Therefore, the early prediction PHI occurrence is useful to evaluate status improve outcomes. The objective this study was develop validate prognostic model uses information available at admission determine likelihood after TBI. Retrospectively collected data were used logistic regression...
Traditional intravesical instillation treatment in bladder cancer has limited efficacy, which results a high frequency of recurrence.The aim this study was to report on an epirubicin (EPI)-loaded magnetic multi-walled carbon nanotube (mMWCNTs-EPI) system for place the current formulation.The mMWCNTs-EPI formulated with carboxylated MWCNTs, Fe3O4 nanoparticles, and EPI. Features antitumor activity were investigated.Under effect external magnets, showed sustained release prolonged retention...
Glibenclamide is a hypoglycemic drug that widely used for the treatment of diabetes mellitus type 2 (DM II), but it also plays protective role following injury to central nervous system (CNS). However, precise mechanisms underlying its neuroprotective actions remain be elucidated. Therefore, present study evaluated effects glibenclamide on blood-brain barrier (BBB) in mouse model traumatic brain (TBI). In study, 86 adult male C57BL/6 mice were exposed controlled cortical impact (CCI) and...
A Rh(III)-catalyzed cascade [3 + 2] annulation of N-phenoxyacetamides with propiolates under mild conditions using the internal oxidative O–N bond as directing group has been achieved. This catalytic system provides a regio- and stereoselective access to benzofuran-2(3H)-ones bearing exocyclic enamino motifs exclusive Z configuration selectivity, acceptable good yields functional compatibility. Mechanistic investigations by experimental density theory studies suggest that consecutive process...
An efficient and convenient cobalt-catalyzed ortho-C(sp2)–H amidation of benzaldehydes employing dioxazolones as the aminating reagent has been developed. The key feature this protocol is use green economic earth-abundant metals cobalt catalyst with p-chloroaniline transient directing group. Further application our approach was demonstrated by synthesis C1r serine protease inhibitor 45 elastase 49.
Abstract The lysyl oxidase (LOX) family is closely related to the progression of glioma. To ensure clinical significance LOX in glioma, Cancer Genome Atlas (TCGA) database was mined and analysis indicated that higher LOXL1 expression correlated with more malignant glioma progression. functions promoting cell survival inhibiting apoptosis were studied by gain- loss-of-function experiments cells animals. found exhibit antiapoptotic activity interacting multiple antiapoptosis modulators,...
Early estimation of prognosis for the patient with traumatic brain injury is an important factor in making treatment decisions, resource allocation, classify patients, or communicating family. We aimed to develop and validate practical prognostic models mortality at 30 days 6 months unfavorable outcome after moderate severe injury.Retrospectively collected data from our department were used outcome. developed four based on admission predictors logistic regression analysis. The performance...
According to the pathoanatomic classification system, progressive hemorrhagic injury (PHI) can be categorized into intraparenchymal contusion or hematoma (pIPCH), epidural (pEDH), subdural (pSDH), and traumatic subarachnoid hemorrhage (ptSAH). The clinical features of each type differ greatly. objective this study was determine predictors, management, outcomes PHI according classification.Multivariate logistic regression analysis used identify independent risk factors for subgroup. Patients...
Human embryonic stem cell (hESC) culture is routinely performed using inactivated mouse fibroblasts (MEFs) as a feeder layer (FL). Although these cells maintain pluripotency of hESCs, the molecular basis for this unknown. Objectives study were to determine whether timing between MEF inactivation and their use FL influenced hESC growth differentiation, begin defining mechanism(s) involved. hESCs plated on MEFs prepared 1 (MEF-1), 4 (MEF-4), 7 (MEF-7) days earlier. colony morphology Oct3/4...
Fe3O4 nanoparticles have been conjugated to curcumin (CU) molecules via a citrate (CA) linker (Fe-CA-CU) and explored for superoxide scavenging, tumor suppression, cancer hyperthermia. The conjugation chemistry reveals that Fe3+ ions on the nanoparticle surface readily conjugates available carboxyl sites CA molecule, which further CU at its central enol -OH group. As seen from UV-vis spectroscopy, therapeutically active chromophore group of CU, is 423 nm, was intact, ensuring activity...
An efficient and convenient copper-mediated method has been developed to achieve direct cascade C-H/N-H annulation synthesize 2-quinolinones from electron-deficient acrylamides arynes. This highlights an emerging but simple strategy transform inert C-H bonds into versatile functional groups in organic synthesis provide a new of synthesizing efficiently. Mechanistic investigations by experimental density theory (DFT) studies suggest that organometallic activation via Cu(iii) intermediate is...
An efficient and convenient ligand-free, rhodium-catalyzed ortho-C(sp2)-H amidation of benzaldehydes with dioxazolones using H2O as the key promoter is described. Using this protocol, a wide range benzaldehyde substrates were selectively amidated in good to excellent yields broad functional group compatibility. KIE experiments revealed that C-H bond activation was likely rate-limiting step. In addition, computational studies indicated catalyst precursor interacted water generate active...
Aggressive metastasis of tumor cells assumed a constructive role in strengthening chemoresistance tumors, so this investigation was intended to elucidate if lncRNA CCAT2 sponging downstream miR-424 regulated chemotolerance glioma by boosting cells.One hundred and twenty-eight pairs tissues corresponding adjacent were resected from patients during their operation, we also purchased series cell lines, including U251, U87, A172 SHG44. Furthermore, pcDNA3.1-CCAT2, si-CCAT2, mimic inhibitor...
Purpose: To discuss the repeated CT scanning in patients with traumatic brain injury (TBI) and to identify conditions under which this approach is necessary.Methods: One hundred seventy-one who suffered TBI but were not surgically treated divided into two groups: routine-repeat group (n = 89) non-routine-repeat 82). The patients' clinical characteristics compared. T-tests stepwise logistic regression used for analysis. Patients three groups according GCS scores determine need routinely...
Glioblastoma (GBM) is the most malignant nervous system tumor with an almost 100 % recurrence rate. Thymopoietin (TMPO) has been demonstrated to be upregulated in various tumors, including lung cancer, breast and so on, but its role GBM not reported. This study was aimed determine of TMPO GBM. Publicly available Oncomine dataset analysis used explore expression level specimens. Then knocked down cells using lentiviral system, knockdown efficacy further validated by real-time quantitative PCR...
Background and Purpose Recent evidence has supported the neuroprotective effect of bpV (pic), an inhibitor phosphatase tensin homolog deleted on chromosome 10 (PTEN), in models ischemic stroke. However, whether PTEN inhibitors improve long-term functional recovery after traumatic brain injury (TBI) affects blood barrier (BBB) permeability need further elucidation. The present study was performed to address these issues. Methods Adult Sprague-Dawley rats were subjected fluid percussion (FPI)...