A5009292967- Schizophrenia research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Workplace Health and Well-being
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Neurological Disease Mechanisms and Treatments
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Mental Health Treatment and Access
- Anesthesia and Pain Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Healthcare Policy and Management
- Mental Health and Psychiatry
- Intracerebral and Subarachnoid Hemorrhage Research
- Pancreatitis Pathology and Treatment
- Apelin-related biomedical research
- Medication Adherence and Compliance
- Congenital Heart Disease Studies
- Medicinal Plants and Bioactive Compounds
- Congenital heart defects research
- Epilepsy research and treatment
University of Pennsylvania
2019-2025
Hebei Medical University
2025
Shanghai Sixth People's Hospital
2015-2024
Shanghai Jiao Tong University
2014-2024
Tengzhou Central People's Hospital
2024
Second Affiliated Hospital of Nanjing Medical University
2019-2024
Chinese Academy of Fishery Sciences
2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Janssen Scientific Affairs (United States)
2023
Background: Beginning in 2012, direct oral anticoagulants (DOACs) were approved for treatment and prevention of venous thromboembolism. Prior investigations have demonstrated slow rates adoption novel therapeutics black patients. We assessed the association racial/ethnic socioeconomic factors with DOAC use among commercially insured thromboembolism Methods Results: performed a retrospective cohort analysis adult patients an incident diagnosis between January 2010 December 2016 using...
Cerebrolysin and DL-3-n-butylphthalide (NBP) have each shown neuroprotective efficacy in preclinical models of acute ischemic stroke (AIS) passed clinical trials as therapeutic drugs for AIS. The present study was a trial to assess compare the safety NBP reduction neurological behavioral disability following A randomized, double‑blind conducted with enrolment 60 patients within 12 h In addition routine treatment, were randomly assigned receive 10‑day intravenous administration NBP, or...
Optimizing resuscitation to reduce inflammation and organ dysfunction following human trauma-associated hemorrhagic shock is a major clinical hurdle. This limited by the short duration of pre-clinical studies sparsity early data in setting.
Daily oral antipsychotics (OAPs) are the mainstay of schizophrenia treatment; however, long-acting injectable (LAIs) associated with better treatment adherence and improved outcomes. This study assessed real-world comparative effectiveness LAIs daily OAPs using claims data from a nationally representative sample fee-for-service Medicare beneficiaries schizophrenia. Antipsychotic discontinuation, psychiatric hospitalization, failure were compared relative to different reference groups...
<title>Abstract</title> <bold>Background:</bold> Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder that often progresses to heart failure with preserved ejection fraction (HFpEF), substantially impacting patient prognosis. However, the clinical characteristics and prognostic significance of HFpEF in HCM are not well understood. This study aims identify key predictors adverse outcomes patients develop machine learning-based risk stratification model for improved management....
Summary Aims It has been well documented that angiotensin II type 1 ( AT ) receptor blockers ARB s) are known to attenuate neural damage and the c‐Jun N ‐terminal protein kinase 3 JNK 3) pathway caspase‐3 signal involved in neuronal cell death following cerebral ischemia/reperfusion I / R ). In this study, we first showed losartan could protect neurons against ‐induced injury. Methods Cerebral ischemia model was induced by four‐vessel occlusion. Antisense oligodeoxynucleotides ODN were used...
Promotion of new blood vessel formation is a strategy for treating ischemic stroke. Non-coding miRNAs have been recently considered potential therapeutic targets miR-181b has shown to promote angiogenesis in hypoxia and traumatic brain injury model, while its effect on stroke remains elusive. In this study, we found that overexpression microvascular endothelial cells subjected oxygen-glucose deprivation vitro restored cell proliferation enhanced angiogenesis. rat models focal cerebral...
The pathogenesis of diabetic neurological complications is not fully understood. Diabetes mellitus (DM) and Alzheimer’s disease (AD) are characterized by amyloid deposits. Glycogen synthase kinase-3 (GSK-3) plays an important role in the AD DM. Here we tried to investigate production amyloid- β peptides (A ) phosphorylation microtubule-associated protein tau DM rats elucidate GSK-3 Akt (protein kinase B, PKB) these processes. Streptozotocin injection-induced displayed increased activity,...
No research to date has examined antipsychotic (AP) use, healthcare resource use (HRU), costs, and quality of care among those with schizophrenia in the Medicare program despite it serving as primary payer for half individuals US.To provide national estimates assess regional variation AP treatment utilization, HRU, measures beneficiaries schizophrenia.Cross-sectional descriptive analysis 100% claims data from 2019. The sample included all adult continuous fee-for-service coverage ≥1...
Transient receptor potential vanilloid 1 (TRPV1) is expressed widely in the central nervous system and activated by various stimuli. Inhibiting TRPV1 has neuroprotective effects cerebral ischemia. The role of inhibiting to maintain blood-brain barrier (BBB) integrity after traumatic brain injury (TBI) remains unclear, however. Therefore, we investigated capsazepine-mediated inhibition on BBB a mouse model TBI. Adult male C57BL/6 mice underwent controlled cortical impact received capsazepine...
Cannon, Jeremy W. MD; Holena, Daniel N. Geng, Zhi MD, MPH; Stewart, Ian J. Huang, Yanlan MS; Yang, Wei PhD; Mayhew, Emily R. Nessen, Shawn C. DO; Gross, Kirby Schwab, William MD Author Information
Adjudin, a small molecular compound that is used as male contraceptive, has been reported to play neuroprotective role in an ischemic stroke injury model. However, its effect on traumatic brain (TBI) not assessed. Hence, we investigated the effects of adjudin cerebral edema using mouse model TBI and explored underlying mechanisms. Adult C57BL/6 mice received controlled cortical impact (CCI) injury, then injection (50 mg/kg). The were euthanized 3 days post-CCI samples collected for further...
Background Familial hypercholesterolemia ( FH ), is a historically underdiagnosed, undertreated, high‐risk condition that associated with high burden of cardiovascular morbidity and mortality. In this study, we use population‐based approach using electronic health record EHR )‐based algorithms to identify . We report the major adverse events, mortality, cost medical care diagnosis. Methods Results our 1.18 million EHR‐ eligible cohort, International Classification Diseases, Ninth Revision...
We reported a GNE myopathy with congenital thrombocytopenia on young male patient. He presented 3-year history of lower distal extremity weakness initially affecting his legs. The slowly progressed to proximal legs and upper arms last 6 months. Whole-exome sequencing revealed that the patient harbored two heterozygous gene mutations, including novel insertion mutation c.*1037_*1038CACACACACACACACACACACA c.C478T in exome 12 3 (NM_001128227), respectively. levels serum sialic acid this were...
Damage-control resuscitation (DCR) improves survival in severely bleeding patients. However, deviating from balanced transfusion ratios during a may limit this benefit. We hypothesized that maintaining DCR is independently associated with improved survival.This was secondary analysis of the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study. Patients receiving >3 U packed red blood cells (PRBCs) any 1-hour period over first 6 hours and surviving beyond 30 minutes...
Autophagy is involved in the development of numerous illnesses, including ischemia/reperfusion (I/R). Endothelial nitric oxide synthase (eNOS) participates protective effects ischemic postconditioning (IPostC). However, it remains unclear whether eNOS-mediated autophagy serves as a critical role IPostC hearts mice, protecting against I/R injury. In present study, mice with left anterior descending coronary artery ligation were studied models. H9c2 cells underwent exposure to...
Novel P2Y12 inhibitors prasugrel and ticagrelor were approved for patients with acute coronary syndrome (ACS) in 2009 2011, respectively. We assessed the association of racial, ethnic, socioeconomic factors initiation adherence to novel a commercially insured population.