A5100458291- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Microscopic Colitis
- Gastrointestinal motility and disorders
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Inflammatory Bowel Disease
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Helicobacter pylori-related gastroenterology studies
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Acute Ischemic Stroke Management
- Vaccine Coverage and Hesitancy
- Nutrition and Health in Aging
- Influenza Virus Research Studies
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Blood Coagulation and Thrombosis Mechanisms
- Animal Disease Management and Epidemiology
- Ophthalmology and Visual Impairment Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Platelet Disorders and Treatments
- Body Composition Measurement Techniques
Shanghai Jiao Tong University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Peking Union Medical College Hospital
2022-2025
Fox Chase Cancer Center
2020-2025
Shanghai Children's Hospital
2015-2024
Tianjin University of Traditional Chinese Medicine
2003-2024
Institute of Special Animal and Plant Sciences
2024
Chinese Academy of Agricultural Sciences
2024
Wuhan No.1 Hospital
2022-2024
National Institute for Viral Disease Control and Prevention
2011-2024
Abstract Background Patients with critical illness due to infection the 2019 coronavirus disease (COVID-19) show rapid progression acute respiratory failure. The study aimed screen most useful predictive factor for caused by COVID-19. Methods prospectively involved 61 patients COVID-19 as a derivation cohort, and 54 validation cohort. was selected using LASSO regression analysis. A nomogram based on non-specific laboratory indicators built predict probability of illness. Results...
Abstract Background Severe ill patients with 2019 novel coronavirus (2019-nCoV) infection progressed rapidly to acute respiratory failure. We aimed select the most useful prognostic factor for severe illness incidence. Methods The study prospectively included 61 2019-nCoV treated at Beijing Ditan Hospital from January 13, 2020 31, 2020. Prognostic of was selected by LASSO COX regression analyses, predict probability 2019-CoV pneumonia. predictive accuracy evaluated concordance index,...
Abstract Fecal microbiota transplantation (FMT) by manual preparation has been applied to treat diseases for thousands of years. However, this method still endures safety risks and challenges the psychological endurance acceptance doctors, patients donors. Population evidence showed washed with microfiltration based on an automatic purification system followed repeated centrifugation plus suspension three times significantly reduced FMT-related adverse events. This washing makes delivering a...
Fecal microbiota transplantation (FMT) is a promising strategy that involves reconstruction of gut microbiota.Recently, it has been considered as treatment Crohn's disease (CD) and certain neurological diseases.Here, to the best our knowledge, we report first case used FMT achieve remission intestinal symptoms in girl with CD 17-year history epilepsy.During 20 mo follow-up, proved its efficacy preventing relapse seizures after withdrawing antiepileptic drugs.Furthermore, this finding...
The strategy of using fecal microbiota transplantation (FMT) for refractory ulcerative colitis (UC) remains unclear if single FMT failed to induce remission. This study aimed evaluate the efficacy and safety a designed step-up steroid-dependent UC. Fifteen patients with UC were enrolled, treated strategy. Follow-up clinical data was collected minimum 3 months. Fecal composition before post related donors analyzed by 16S rRNA sequencing. Eight fourteen (57.1 %) achieved improvement able...
Abstract Background In China, a rapid expansion of Hand, foot, and mouth disease (HFMD) outbreaks has occurred since 2004 HFMD become an important issue for China. However, people are still only concerned with human enterovirus 71(HEV-71) coxsackie virus A16 (CV-A16). Much what is known about the other infections relies on fractional evidence old epidemic data, little knowledge concerning their distribution. To alert potential threatens enteroviruses, our study genetically characterized...
Placement of a tube through the anus into cecum has not yet been established as method administering whole-colonic treatment. The aim this study was to evaluate safety, feasibility, and value transendoscopic enteral tubing (TET) for fecal microbiota transplantation (FMT) colon.A prospective observational performed FMT using new colonic TET technique. Under endoscopic guidance, affixed with clips. value, satisfaction by were evaluated.A total 54 patients underwent TET. success rate procedure...
Recent studies reported that patients with coronavirus disease-2019 (COVID-19) might have liver injury. However, few data on the combined analysis and change patterns of alanine aminotransferase (ALT), aspartate (AST) total bilirubin (TBil) been shown.This is a single-center retrospective study. A 105 adult hospitalized for confirmed COVID-19 in Beijing Ditan Hospital between January 12, March 17, 2020 were included, divided into mild group (n = 79) severe group(n 26). We compared functional...
The Infectious Disease Surveillance of Pediatrics (ISPED) program was established in 2015 to monitor and analyze the trends bacterial epidemiology antimicrobial resistance (AMR) children. Clinical isolates were collected from 11 tertiary care children's hospitals China 2016 2020. Antimicrobial susceptibility testing carried out using Kirby-Bauer method or automated systems, with interpretation according Laboratory Standards Institute 2019 breakpoints. A total 288,377 collected, top 10...
The ancient Chinese medical literature, as well our prior clinical experience, suggests that fecal microbiota transplantation (FMT) could treat the inflammatory mass. We aimed to evaluate efficacy and safety of multiple fresh FMTs for Crohn's disease (CD) complicated with intraabdominal "one-hour FMT protocol" was followed in all patients. Twenty-five patients were diagnosed CD related mass by CT or MRI. All received initial repeated every 3 months. primary endpoint response (improvement...
Fecal microbiota transplantation (FMT) has been used as a potential treatment option for Crohn's disease (CD). However, there is still lack of safety and efficacy evidence based on large samples CD undergoing FMT. This study aimed to evaluate the risk factors adverse event (AE) in long term FMT short patients with CD.FMT via mid-gut mild severe single center trial (NCT01793831) was performed from October 2012 December 2016. The possible AE after were prospectively recorded.A total 184...
Gut dysbiosis is a characteristic of inflammatory bowel disease (IBD) and believed to play role in the pathogenesis IBD. Fecal microbiota transplantation (FMT) an effective strategy restore intestinal microbial diversity has been reported have potential therapeutic value Our recent study holistic integrative therapy called “step-up FMT strategy,” which was beneficial treating steroid-dependent IBD patients. This consists scheduled FMTs combined with steroids, anti-TNF-α antibody treatment or...
Background: With the continuous large-scale development of COVID-19 vaccine, acceptance vaccination and its influencing factors at individual level have become crucial to stemming pandemic. This study aims explore that influence vaccine among international college students. Methods: The target population constituted students pursuing various degrees in Jiangsu Province through an online cross-sectional study. A cluster random sampling was performed using a self-administered questionnaire....
Paxlovid is recognized as an effective medication in preventing the progression of coronavirus disease 2019 (COVID-19) to severe form adults; however, its efficacy has remained unknown pediatric cases. This study aimed analyze feasibility, safety, and treatment acute respiratory syndrome 2 (SARS-CoV-2)-infected children aged 6-14 years.We conducted a cohort based on prospectively collected clinical data. We recruited 5 cases with underlying diseases treated from 7 April 2022 26 May 30...
Abstract The prevalence of Clostridium difficile infection (CDI) in patients suffering from inflammatory bowel disease (IBD) has increased rapidly over the past several decades North America and Europe. However, exact global epidemiology remains unclear because insufficient data developing countries. A total 646 hospitalized adult IBD were enrolled; their fresh stool specimens obtained used for detection. incidence CDI Crohn’s (CD) (12.7%) was significantly lower than that Ulcerative (UC)...
Light is an important environmental factor, which mainly inhibits hypocotyl elongation through various photoreceptors. In contrast, brassinosteroids (BRs) are major elongation-promoting hormones in plants, could optimize photomorphogenesis concurrent with external light. However, the precise molecular mechanisms underlying antagonism of light and BR signaling remain largely unknown. Here we show that Arabidopsis red receptor phyB involved inhibition via its direct interaction transcription...
INTRODUCTION: The previous researches aimed to evaluate the efficacy and safety of fecal microbiota transplantation (FMT) for ulcerative colitis (UC) in a short-term observation. present study explore optimum timing FMT maintaining long-term clinical benefits target gut that may help predict success or failure UC. METHODS: Two hundred two patients with UC were recruited from November 2012 September 2018. primary endpoint this was time first second courses FMT. Relapse defined as partial Mayo...