A5101873042- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer Research and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Lipid metabolism and disorders
- Telomeres, Telomerase, and Senescence
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Gut microbiota and health
- Cancer, Lipids, and Metabolism
- Caveolin-1 and cellular processes
- Tryptophan and brain disorders
- Radiomics and Machine Learning in Medical Imaging
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- Axon Guidance and Neuronal Signaling
- COVID-19 and healthcare impacts
- Glutathione Transferases and Polymorphisms
- MicroRNA in disease regulation
- Fatty Acid Research and Health
- Animal Genetics and Reproduction
Southwest Hospital
2023-2024
Army Medical University
2022-2024
Hebei GEO University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
Kunming Medical University
2023
Affiliated Eye Hospital of Wenzhou Medical College
2023
Wenzhou Medical University
2023
Southern Medical University
2022-2023
State Key Laboratory of Ophthalmology
2023
Background: Accumulating evidence has shown that neuropsychiatric disorders are associated with gut microbiota through the gut-brain axis. However, effects of antidepressant treatment on rarely studied. Here, we investigated whether stress led to changes and fluoxetine plays a role in alteration. Methods: We depression model induced by chronic unpredicted mild (CUMS) restoration applying classic drug fluoxetine. Results: found low bacterial diversity, simpler network, increased abundance...
Depression and obesity have high concurrence within individuals, which may be explained by sharing the same risk factors, including disruption of intestinal microbiota.However, evidence that delineated causal connections is extremely scarce.Methods: Mice lacking fat mass-and obesity-associated gene (Fto) were generated.Fto-deficient wild-type control mice subjected to novel conditions with or without chronic unpredictable mild stress (CUMS) for 6 weeks.Some treated antibiotics via their...
Recent studies reported that patients with coronavirus disease-2019 (COVID-19) might have liver injury. However, few data on the combined analysis and change patterns of alanine aminotransferase (ALT), aspartate (AST) total bilirubin (TBil) been shown.This is a single-center retrospective study. A 105 adult hospitalized for confirmed COVID-19 in Beijing Ditan Hospital between January 12, March 17, 2020 were included, divided into mild group (n = 79) severe group(n 26). We compared functional...
Insufficient or disrupted sleep increases the risk of cardiovascular disease, including atherosclerosis. However, we know little about molecular mechanisms by which modulates atherogenesis. This study aimed to explore potential role circulating exosomes in endothelial inflammation and atherogenesis under deprivation status involved.Circulating were isolated from plasma volunteers with without mice subjected 12-week control littermates. miRNA array was performed determine changes expression...
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. Insulin resistance (IR) important in development and progression NAFLD. Nuclear erythroid 2‑related factor 2 (Nrf2) has previously been reported to be a novel regulator The present study determined that Nrf2 knockdown accelerated onset obesity non‑alcoholic steatohepatitis (NASH), via induction IR mice fed high‑fat diet (HFD), which was confirmed by an increase total weight Nrf2‑null‑HFD mice,...
Background The giant panda has an interesting bamboo diet unlike the other species in order of Carnivora. umami taste receptor gene T1R1 been identified as a pseudogene during its genome sequencing project and confirmed using different sample. estimated mutation time for this is about 4.2 Myr. Such coincided with panda's dietary change also reinforced herbivorous life style. However, preserved herbivores such cow horse, we need to look reasons behind switch. Methodology/Principal Findings...
Background Patients with ulcerative colitis (UC) are at an increased risk of developing Clostridioides difficile infection (CDI), which in turn leads to poor outcomes. The gut microbial structure and metabolites patients UC CDI have been scarcely studied. We hypothesized that changes the microbiota UC. Materials Methods This study included 89 patients: 30 healthy controls (HC group), 29 alone (UCN (UCP group). None participants has exposed antibiotic treatments during 3 months before stool...
Conjugated linolenic acid (CLN) refers to a group of octadecatrienoic isomers that have three double bonds in conjugation. Both pomegranate and tung seed oils are rich CLN but the major isomer former is cis 9, trans 11, 13 while latter it 13. The present study examined effects CLN, isolated from either oil or oil, α-linolenic (LN), flaxseed on serum cholesterol levels male hamsters (body weight 105 g; age 10 weeks) fed 0.1 % lard diet, for period 6 weeks. All were allowed free access food...
The depth of cervical stromal invasion is one the important prognostic factors affecting decision-making for early stage cancer (CC). This study aimed to develop and validate a T2-weighted imaging (T2WI)-based radiomics model explore independent risk (factors with statistical significance in both univariate multivariate analyses) middle or deep CC.Between March 2017 2021, total 234 International Federation Gynecology Obstetrics IB1-IIA1 CC patients were enrolled randomly divided into...
Slit-Robo GTPase-activating protein 2 (SRGAP2) plays important roles in axon guidance, neuronal migration, synapse formation, and nerve regeneration. However, the role of SRGAP2 neuroretinal degenerative disease remains unclear. In this study, we found that was first expressed retina normal mice at embryonic stage mainly located mature retinal ganglion cell layer inner nuclear layer. optic increased after crush. Then, established a heterozygous knockout (Srgap2+/-) mouse model crush Srgap2...
Limited information on the oral health status of adult heart transplant recipients (HTRs) is known, and no available data exist in China. A prerequisite dental evaluation usually recommended for patients' postorgan transplantation because lifelong immunosuppression may predispose them to infection spread.The aim this study was investigate Chinese HTRs determine association between history (HT).We carried out a cross-sectional collect clinical, demographic, socioeconomic, behavioral from 81...
We primarily quantified exposure patterns, transmission characteristics, and the clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among household contacts individuals with disease-2019 (COVID-19). conducted a retrospective cohort study 20 index patients hospitalized COVID-19 79 their contacts. determined frequency, range manifestations SARS-CoV-2 infection, factors associated in settings. Of contacts, 53 (67%) developed (49 [62%] symptomatic, 4 [5%]...
Human beings are currently experiencing a serious public health event. Novel coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome (SARS-CoV-2), has infected about 3 million people worldwide and killed more than 200,000, most being elderly or with potential chronic diseases in immunosuppressive states. According to big data analysis, there many proteins homologous interacting angiotensin-converting enzyme 2 (ACE2), which, therefore, may not be only...
Abstract Recent studies reported sex differences in patients with coronavirus disease‐2019 (COVID‐19). We aim to analyze clinical characteristics and risk factors for disease severity of hospitalized COVID‐19 Beijing. All adults (185 cases) diagnosed admitted Beijing Ditan Hospital, Capital Medical University were included samples. The median age all was 41 years. mean body mass index (BMI) males relatively higher compared females ( p < 0.001). proportion male coronary heart (CHD),...