A5030949210- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Cancer therapeutics and mechanisms
- RNA Interference and Gene Delivery
- Liver Disease and Transplantation
- SARS-CoV-2 detection and testing
- Chemical Synthesis and Analysis
- COVID-19 diagnosis using AI
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Viral Infections and Vectors
- HIV/AIDS drug development and treatment
- Radiopharmaceutical Chemistry and Applications
- RNA and protein synthesis mechanisms
- Cancer Treatment and Pharmacology
- Liver Diseases and Immunity
- Antibiotics Pharmacokinetics and Efficacy
Beijing Shijitan Hospital
2024-2025
Capital Medical University
2008-2025
First Affiliated Hospital Zhejiang University
2017-2024
Peking University
2014-2024
Peking University International Hospital
2018-2024
Peking University First Hospital
2013-2024
Center for Digestive and Liver Diseases
2024
Beijing Jishuitan Hospital
2024
Guizhou University
2024
Beijing Ditan Hospital
2011-2024
Objective The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province determine epidemiological, clinical virological characteristics. Design hospital patients were admitted from 17 January 2020 8 February 2020. Epidemiological, demographic, clinical, laboratory, management outcome data of using multivariate analysis for...
The real-time reverse transcription-polymerase chain reaction (RT-PCR) detection of viral RNA from sputum or nasopharyngeal swab had a relatively low positive rate in the early stage coronavirus disease 2019 (COVID-19). Meanwhile, manifestations COVID-19 as seen through computed tomography (CT) imaging show individual characteristics that differ those other types pneumonia such influenza-A (IAVP). This study aimed to establish an screening model distinguish IAVP and healthy cases pulmonary...
Abstract Continued reliance on the androgen receptor (AR) is now understood as a core mechanism in castration-resistant prostate cancer (CRPC), most advanced form of this disease. While established and novel AR pathway–targeting agents display clinical efficacy metastatic CRPC, dose-limiting side effects remain problematic for all current agents. In study, we report discovery development ARN-509, competitive inhibitor that fully antagonistic to overexpression, common important feature CRPC....
An outbreak of coronavirus disease 2019 (COVID-19) is becoming a public health emergency. Data are limited on the duration and host factors related to viral shedding.In this retrospective study, risk associated with severe acute respiratory syndrome 2 (SARS-CoV-2) RNA shedding were evaluated in cohort 113 symptomatic patients from hospitals outside Wuhan.The median (interquartile range) SARS-CoV-2 detection was 17 (13-22) days as measured illness onset. When comparing early (<15 days) late...
Infectious diseases and antimicrobial resistance (AMR) has become pressing concerns in China. We aimed to comprehensively investigate the burden of them.Data on infectious AMR were collected by Global Antimicrobial Resistance Burden study 2019. Multinomial network meta-regression, logistic regression, ensemble Spatiotemporal Gaussian process regression used fit number rate DisMod-MR 2.1 modelling framework. reported rates disease burdens 12 syndromes age sex; described caused 43 pathogens;...
Recombinant interferon-beta-1b (IFN-beta-1b) is used clinically in the treatment of multiple sclerosis. In common with many biological ligands, IFN-beta-1b exhibits a relatively short serum half-life, and bioavailability may be further diminished by neutralizing antibodies. While PEGylation an approach commonly employed to increase blood residency time protein therapeutics, there requisite for molecular engineering approaches also address stability, solubility, aggregation, immunogenicity...
CPT-11, also known as irinotecan, is a prodrug that approved for the treatment of advanced colorectal cancer. The active metabolite SN38 (7-ethyl-10-hydroxy-camptothecin), has 100- to 1000-fold more potent cytotoxic activity in tissue cell culture compared with CPT-11. However, parental administration not possible because its inherently poor water solubility. It reported here multiarm poly(ethylene glycol) (PEG) backbone linked four molecules (PEG-SN38) been successfully prepared high drug...
Clinical development of SN38, the active metabolite camptothecin-11 (CPT-11), has been hampered due to its poor solubility. We have developed a novel polymer-drug conjugate, EZN-2208, made by linking SN38 with multiarm polyethylene glycol via glycine linker.The in vitro cytotoxicity EZN-2208 was tested using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. The therapeutic efficacy evaluated various xenografts, including an vivo-selected...
Background. Systematic analysis of histopathological and serial virological changes fatal influenza A(H7N9) cases is lacking. Methods. Patients with infection admitted to our intensive care unit during 10–23 April 2013 were included. Viral loads in the respiratory tract, as inferred from cycle threshold (Ct) value reverse transcription polymerase chain reaction (RT-PCR), serum hemagglutination inhibition (HAI) antibody titer, analyzed. Postmortem biopsies lung, liver, kidney, spleen, bone...
浙江大学医学院附属第一医院感染科收治一名新型冠状病毒 (SARS-CoV-2) 感染的妊娠晚期孕妇. 在其住院期间, 患者进行了剖腹产术, 新生儿被证实无 SARS-CoV-2 感染. 结合已有的相关文献报道, 通过母婴垂直传播的依据不足, 同时乳汁的病毒检测阴性, 因此目前不能证明 病毒能通过乳汁传播. 通过研究, 我们建议感染 的孕妇, 在治愈出院后, 应经过两周隔离观察, 并且病毒复查结果为阴性, 才可以进行母乳喂养.
Since December 2019, COVID-19 has spread to almost every corner of the world. In theory, tocilizumab and favipiravir are considered be reliable drugs for treatment with elevated IL-6. We aimed assess efficacy safety combined in patients COVID-19. This was a multicenter trial adults Patients were randomly assigned (3:1:1) 14-day combination (combination group), favipiravir, tocilizumab. The primary outcome cumulative lung lesion remission rate (lung CT examination indicated absorption...
Circulating cell-free DNA (cfDNA) is a potential biomarker for tumor diagnosis. Hepatocyte damage characteristic component of the pathobiology hepatocellular carcinoma (HCC), which would be expected to result in substantial leakage cfDNA into circulation. However, diagnostic value levels HCC remains unclear.Plasma samples were collected from 24 patients and 62 hepatitis B virus-related liver fibrosis patients. Plasma quantified by Qubit method.Plasma associated with degree inflammation, body...
The novel coronavirus COVID-19, has caused a worldwide pandemic, impairing several human organs and systems. Whether COVID-19 affects thyroid function remains unknown.Eighty-four hospitalized patients in the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, China) were retrospectively enrolled this study, among which 22 cases had complete records hormones. In addition, 91 other with pneumonia 807 healthy subjects included as controls.We found that levels total...
Recent studies reported that patients with coronavirus disease-2019 (COVID-19) might have liver injury. However, few data on the combined analysis and change patterns of alanine aminotransferase (ALT), aspartate (AST) total bilirubin (TBil) been shown.This is a single-center retrospective study. A 105 adult hospitalized for confirmed COVID-19 in Beijing Ditan Hospital between January 12, March 17, 2020 were included, divided into mild group (n = 79) severe group(n 26). We compared functional...
Convincing UV and NMR spectrophotometric evidence is presented which demonstrates that at physiological pH, 7.4, 20-O-acyl derivatives of camptothecin (CPT) are substantially more stable in the lactone form than 20-OH parent. Additionally, it was determined by HPLC analysis ring a 20-O-ether derivative CPT underwent endocyclic opening pH ≥ 8.5, while remained unaffected. PEG (and other smaller alkyl) 20-O-acyl-CPT released native > 9.5, arises from exocyclic cleavage, thus precluding...
Hepatic recompensation may be achieved in patients with decompensated cirrhosis due to chronic hepatitis B (CHB) upon effective suppression of viral replication by nucleos(t)ide analogues (NAs). However, the optimal timing and predictors subsequent clinical course CHB