A5023571218- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Lung Cancer Research Studies
- COVID-19 diagnosis using AI
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- HIV-related health complications and treatments
- Radiomics and Machine Learning in Medical Imaging
- HIV Research and Treatment
- Polyomavirus and related diseases
- Advanced Graph Neural Networks
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 and healthcare impacts
- CAR-T cell therapy research
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 detection and testing
- Immunodeficiency and Autoimmune Disorders
- AI in cancer detection
- Cytomegalovirus and herpesvirus research
Zhejiang University
2016-2025
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2016-2025
Sir Run Run Shaw Hospital
2025
Kunming Medical University
2025
First Affiliated Hospital Zhejiang University
2013-2024
Southern Medical University
2023-2024
Guangdong Provincial People's Hospital
2021-2024
University of Hong Kong
2024
Guangdong Academy of Medical Sciences
2021-2024
National Clinical Research Center for Digestive Diseases
2022-2024
Objective The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province determine epidemiological, clinical virological characteristics. Design hospital patients were admitted from 17 January 2020 8 February 2020. Epidemiological, demographic, clinical, laboratory, management outcome data of using multivariate analysis for...
The real-time reverse transcription-polymerase chain reaction (RT-PCR) detection of viral RNA from sputum or nasopharyngeal swab had a relatively low positive rate in the early stage coronavirus disease 2019 (COVID-19). Meanwhile, manifestations COVID-19 as seen through computed tomography (CT) imaging show individual characteristics that differ those other types pneumonia such influenza-A (IAVP). This study aimed to establish an screening model distinguish IAVP and healthy cases pulmonary...
An outbreak of coronavirus disease 2019 (COVID-19) is becoming a public health emergency. Data are limited on the duration and host factors related to viral shedding.In this retrospective study, risk associated with severe acute respiratory syndrome 2 (SARS-CoV-2) RNA shedding were evaluated in cohort 113 symptomatic patients from hospitals outside Wuhan.The median (interquartile range) SARS-CoV-2 detection was 17 (13-22) days as measured illness onset. When comparing early (<15 days) late...
Predicting the clinical response to chemotherapeutic or targeted treatment in patients with locally advanced metastatic lung cancer requires an accurate and affordable tool. Tumor organoids are a potential approach precision medicine for predicting treatment. However, their application has rarely been reported because of difficulty generating pure tumor organoids. In this study, we have generated 214 from 107 patients, which 212 (LCOs), primarily derived malignant serous effusions. LCO-based...
The novel coronavirus COVID-19, has caused a worldwide pandemic, impairing several human organs and systems. Whether COVID-19 affects thyroid function remains unknown.Eighty-four hospitalized patients in the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, China) were retrospectively enrolled this study, among which 22 cases had complete records hormones. In addition, 91 other with pneumonia 807 healthy subjects included as controls.We found that levels total...
Knowledge about the 1-year outcome of COVID-19 is limited. The aim this study was to follow-up and evaluate lung abnormalities on serial computed tomography (CT) scans in patients with after hospital discharge.A prospective cohort from First Affiliated Hospital, Zhejiang University School Medicine conducted, assessments chest CT during hospitalization at 2 weeks, 1 month, 3 months, 6 year discharge. Risk factors residual opacities influence pulmonary functions were also evaluated.A total 41...
Abstract Background Effective antiviral drugs for COVID-19 are still lacking. This study aims to evaluate the clinical outcomes and plasma concentrations of baloxavir marboxil favipiravir in patients. Methods Favipiravir acid were evaluated their activity against SARS-CoV-2 vitro before trial initiation. We conducted an exploratory with 3 arms involving hospitalized adult patients COVID-19. Patients randomized assigned a 1:1:1 ratio into group, control group. The primary outcome was...
The gut microbiota has an important role in the pathogenesis of hepatic encephalopathy(HE). Rifaximin, intestinal non-absorbable antibacterial agent, is effective treatment HE. However, whether long-term prophylactic use induces resistance and its mechanism for treating HE remains unclear. This prospective study assessed impact 12 weeks rifaximin administration on resistome cirrhotic patients. Fecal sampling was conducted 1 day before first at Weeks 1, 2, 4, 6, 8, 10, study. Thirty patients...
Backgrounds: The rapid initiation of highly active anti-retroviral therapy (HAART) can control HIV-1 viremia and stabilize the long-term health people living with (PLWH). Despite this, individuals who are diagnosed late exhibit poor therapeutic efficacy still pose a great challenge to global HIV management. To address we conducted comprehensive multiparametric immune profiling analyzed its association disease progression efficacy. Methods: Multicolor flow cytometry was used characterize...
Objectives. To evaluate the safety and efficacy of low-dose rituximab therapy for refractory thrombocytopenia in patients with SLE. Methods. Ten adult SLE severe (mean platelet count 10.4 × 109/l) were enrolled this prospective pilot study. All had failed traditional high-dose CSs immunosuppressants including methylprednisolone pulse therapy. Patients scheduled to receive i.v. at a dose 100 mg once weekly 4 weeks. Previous gradually tapered, withdrawn. followed Weeks 4, 12, 24 36. Results....
Objective . To identify blood biomarkers to predict severity and mortality in AIDS PCP patients. Methods Biomarkers including clinical parameters plasma inflammatory cytokines were assessed 32 HIV-infected patients with Pneumocystis pneumonia (PCP) at time of admission. Predictive value the for in-hospital was evaluated by corresponding ROC curve. Results Levels CRP, WBC, LDH, HBDH, Ferritin significantly higher severe nonsurvivor These important biochemical indicators have inverse...
Transformed small-cell lung cancer (T-SCLC) has an extremely poor prognosis, and no remedies based on immunotherapy have been evaluated among T-SCLC patients. We retrospectively analysed the efficacy safety of combining atezolizumab with chemotherapy for T-SCLC.Forty-seven patients harbouring EGFR mutations who developed were enrolled. Eleven used defined as I/O group, remaining 36 Non-I/O group. Clinical characteristics, pathological data, survival outcomes collected. RNA sequencing...
Background: The urgency of the 2019 novel coronavirus outbreak has led to demand effective antiviral agents. Preliminary experiment indicated that Arbidol concentrations might inhibit replication in vitro. However, there was limited data about clinical efficacy coronavirus-infected pneumonia (NCP). Methods: We did a retrospective cohort study NCP patients who received empiric al regimens with or without Arbidol. A total 111 from two centers China were enrolled. Findings: Among these...
Introduction The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been posing a threat to global public health. Although broadly neutralizing antibodies have used prevent or treat corona virus disease 2019 (COVID-19), new emerging variants proven resistant these antibodies. Methods In this study, we isolated receptor binding domain (RBD)-specific memory B cells using single-cell sorting method from two COVID-19 convalescents and expressed the antibody test...
MET dysregulation has been implicated in the development of primary and secondary resistance to EGFR tyrosine kinase inhibitor (TKI) therapy. However, clinicopathological characteristics outcomes patients harboring EGFR-sensitive mutations de novo amplifications still need be explored.A total 54 from our hospital with non-small cell lung cancer and/or were included this study. Survival rates estimated by Kaplan-Meier method log-rank statistics. Lung organoids (LCOs) generated patient-derived...
Abstract Background Patients infected with HIV are at high risk of developing Epstein-Barr Virus (EBV)-related diseases. The genotype and viral biological behavior EBV infection in patients human immunodeficiency virus-1 (HIV) China remain unclear. This study analyzed the characteristics southeastern China. Methods A total 162 HIV-infected 52 without were enrolled this study. load blood was determined by fluorescence quantitative PCR. typing performed using saliva according to polymorphisms...