A5053706585- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- COVID-19 diagnosis using AI
- Full-Duplex Wireless Communications
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Aquaculture disease management and microbiota
- Fungal Infections and Studies
- Porphyrin and Phthalocyanine Chemistry
- Adsorption and biosorption for pollutant removal
- Immunodeficiency and Autoimmune Disorders
- Photochemistry and Electron Transfer Studies
- Parvovirus B19 Infection Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Antifungal resistance and susceptibility
- Infectious Diseases and Tuberculosis
- HIV/AIDS drug development and treatment
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Long-Term Effects of COVID-19
- Microtubule and mitosis dynamics
- Ecology and Vegetation Dynamics Studies
Zhejiang University
2017-2024
Hangzhou Xixi hospital
2019-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2018-2024
Beijing Technology and Business University
2023-2024
Qinghai University
2022-2024
Xinjiang Institute of Ecology and Geography
2024
Chinese Academy of Sciences
2024
China Agricultural University
2023-2024
Ministry of Agriculture and Rural Affairs
2024
Taizhou First People's Hospital
2023
Background The optimal initial induction treatment for HIV-associated Talaromyces marneffei fungemia (HTMF) remains unclear. Methods Three hundred and fifteen patients with were enrolled in this multicenter retrospective study. effectiveness of regimens amphotericin B deoxycholate (iAmBd), voriconazole (iVori), a switch regimen from iVori to AmBd (iVori→AmBd switch) on 180-day all-cause mortality HTMF was assessed. Results prevalence 75.9% (239/315) 20.1% (48/239). Among these patients,...
Abstract Plants can adapt to environmental changes by adjusting their functional traits and biomass allocation. The size number of flowers are related plant reproduction. Life history theory predicts that there is a trade‐off between flower number, the potentially explain adaptability plants. Elevation gradients in mountains provide unique opportunity test how plants will respond climate change. In this study, we tried better alpine Gentiana lawrencei var. farreri response We measured...
Abstract Background The severity of COVID-19 associates with the clinical decision making and prognosis patients, therefore, early identification patients who are likely to develop severe or critical is in practice. aim this study was screen severity-associated markers construct an assessment model for predicting COVID-19. Methods 172 confirmed were enrolled from two designated hospitals Hangzhou, China. Ordinal logistic regression used markers. Least Absolute Shrinkage Selection Operator...
Cervical cancer is the second most common in women worldwide and early detection of cervical crucial to improve performance treatment. Autofluorescence arising from cells tissues can provide information cellular energy metabolism. Fluorescence lifetime imaging microscopy (FLIM) be used detect metabolism change indicating development precancer. In this study, unstained tissue sections obtained patients were detected by FLIM, which exhibited morphology features as clear pathology images...
A35 is a novel synthetic cyclizing-berberine recently patented as an antitumor compound. Based on its dual targeting topoisomerase (top) activity, might overcome the resistance of single-target top inhibitors and has no cardiac toxicity for not top2β. In this study we further explored biological effects mechanisms A35. Antitumor activity was evaluated by SRB colony formation assay. G2/M phase arrest (especially M) first damage M-phase cells were investigated flow cytometry, cytogenetic...
Abstract Background Patients infected with HIV are at high risk of developing Epstein-Barr Virus (EBV)-related diseases. The genotype and viral biological behavior EBV infection in patients human immunodeficiency virus-1 (HIV) China remain unclear. This study analyzed the characteristics southeastern China. Methods A total 162 HIV-infected 52 without were enrolled this study. load blood was determined by fluorescence quantitative PCR. typing performed using saliva according to polymorphisms...
BK polyomavirus (BKPyV) is an opportunistic infectious pathogen that associated with hemorrhagic cystitis and nephropathy, mainly in transplant recipients human immunodeficiency virus 1 (HIV-1) infected patients. However, molecular characterization studies of BKPyV China are rare. This study was designed to elucidate the prevalence determine main subtypes among HIV-1-infected patients southeastern China. In addition, increased incidences for reactivation were analyzed. The isolated DNA...
Pancreatic cancer is a more aggressive and refractory malignancy. Resistance toxicity limit drug efficacy. Herein, we report lower toxic higher effective miriplatin (MPt)-loaded liposome, LMPt, exhibiting totally different anti-cancer mechanism from previously reported platinum agents. Both in gemcitabine (GEM)-resistant/sensitive (GEM-R/S) pancreatic cells, LMPt exhibits prominent activity, led by faster cellular entry-induced larger accumulation of MPt. The level caveolin-1 (Cav-1)...
Up to now, little is known about the detailed immune profiles of COVID-19 patients from admission discharge. In this study we retrospectively reviewed clinical and laboratory characteristics 18 January 30, 2020 February 21, 2020. These were divided into two groups; group 1 had a severe acute respiratory syndrome coronavirus 2 nucleic acid-positive duration for more than 15 days (n = 6) less 12). Group lower level peripheral blood lymphocytes (0.40 vs. 0.78 ×109/L, p 0.024) serum potassium...
Introduction: Pneumocystis pneumonia (PCP) is one of the most common opportunistic infections in HIV-infected patients. However, coinfection with Tropheryma whipplei infrequent AIDS patients PCP. Case Presentation: We report a 28-year-old male patient coinfected T. and jirovecii diagnosed bronchoalveolar lavage. After sulfamethoxazole–trimethoprim meropenem treatment, showed clinical improvement 2 weeks. Conclusion: Clinicians need to be alert occurrence infection PCP timely diagnosis...
The large conjugated system and the d orbitals of metallic phthalocyanines (MPcs) are easily triggered by solvent molecules light to cause variations in photo-physical photo-chemical properties. To clarify novel properties photo-excited MPcs solvents, steady/transient state spectral data were collected investigate four MPc templates, including FePc, ZnPc, CoPc AlClPc. Q bands FePc prone redshift, while peaks ZnPc AlClPc tended blueshift various solvents compared with that DMSO. With xenon...
Objectives Human JC polyomavirus (JCPyV) infection has an increased risk of developing progressive multifocal leukoencephalopathy (PML). Different JCPyV subtypes differ in the virulence with which they cause PML. Currently, status and subtype distribution patients human immunodeficiency virus-1 (HIV-1) China are still unclear. This study aimed to investigate epidemiology HIV-1-infected China. Methods Urine samples from 137 Zhejiang Province were tested for presence DNA. The detected VP1...
Pneumocystis pneumonia (PCP) is a common opportunistic infection in acquired immune deficiency syndrome (AIDS) patients that continues to result high mortality rate. To develop better treatment strategy and improve PCP prognosis, cohort study was conducted evaluate the therapeutic potential of echinocandin for AIDS with (AIDS-PCP).The AIDS-PCP were analyzed our retrospective hospitalized The First Affiliated Hospital Zhejiang University during 2013-2018. antifungal effects echinocandins...
Indoleamine 2, 3-dioxygenase (IDO) is a key enzyme in the degradation of tryptophan (Trp) to kynurenine (Kyn). We measured IDO activity as Kyn Trp ratio, and investigated whether could be used assess prognosis acquired immune deficiency Sydrome (AIDS) patients with pneumocystis pneumonia (PCP). The concentration were by UPLC-MS/MS plasma samples. A total 49 AIDS-PCP included analysis. Clinical characteristics Kyn/Trp ratio compared between survivors non-survivors. was significantly lower...
To examine the relationship between Pneumocystis jirovecii DNA (PJ-DNA) levels in blood from AIDS-associated pneumonia (AIDS-PCP) and mortality, to correlate mitochondrial large subunit rRNA (mtLSUrRNA) gene polymorphism with we performed a retrospective study including AIDS-PCP patients 2014 2016 one hospital China. PJ-DNA plasma was measured by nested polymerase chain reaction (PCR) of mtLSUrRNA positive specimens further detected level using qPCR. Polymorphisms were observed at two...