A5007045422- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Hepatocellular Carcinoma Treatment and Prognosis
- Multiple Myeloma Research and Treatments
- Pharmacological Effects and Toxicity Studies
- Click Chemistry and Applications
- Advanced Drug Delivery Systems
- Tuberculosis Research and Epidemiology
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Vascular Tumors and Angiosarcomas
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Chromatography in Natural Products
- Synthesis and Catalytic Reactions
- Chemokine receptors and signaling
- Cell death mechanisms and regulation
- Acute Myeloid Leukemia Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Ling Tung University
2008
Background & Aims: Only a minority of patients could benefit from systemic therapy owing to the high heterogeneity HCC. Therefore, deeper understanding pathogenesis HCC is essential for precision therapy. Genomic and proteomic studies have enhanced our However, phosphoproteomic characterization remains poorly understood. Approach Results: We conducted an in-depth analysis clinical cohort using high-coverage phosphoproteomic. Effective therapeutic targets were validated liver cancer cell...
The small size of ultra-small nanoparticles makes them suitable for lymphatic delivery, and many recent studies have examined their role in anti-metastasis therapy. However, the anti-metastatic efficacy small-sized nanocarriers loaded with taxanes such as docetaxel has not yet been investigated malignant breast cancer. We encapsulated using poly(D,L-lactide)1300-b-(polyethylene glycol-methoxy)2000 (mPEG2000-b-PDLLA1300) to construct polymeric micelles a mean diameter 16.76 nm (SPM)....
Since regional drug administration enables to maintain a high concentration within tumors, we compared the plasma and biodistribution of doxorubicin (Dox) from drug-loaded conventional liposomes by local or systemic administration. The results demonstrated that was substantially improved in liver as well decrease blood other organs spleen injection mimicking portal vein perfusion (regional administration). To further investigate targeted therapeutic effect galactosylated liposome...
The in vivo distribution of antitumor drugs is usually lack selectivity, and thus, leading to a low efficacy chemotherapy on cancers high toxicity normal cells. Receptor-mediated targeting liposome with pH-sensitivity as dual drug delivery system one the efficient approaches overcome disadvantages. study was synthesize novel smart polymeric material (folate-poly(2-ethyl-2-oxazoline)-distearoyl phosphatidyl ethanolamine, F-PEOz-DSPE), which can combine folate-receptor (FR) over-expressed...
A novel polymer (PEG2000-carborane), self-assembling into spherical vesicles (boron-containing vesicles, BCVs), could be quickly taken up by tumor cells and had an enhance stability in the bloodstream previous study. To have more comprehensive understanding of BCVs, endocytic mechanism cytotoxicity assessment were conducted. The results showed that BCVs intact form with cholesterol-dependent pathway during endocytosis, exhibited nearly no cytotoxicity. accumulate within tumors for at least...
Pancreatic cancer is a more aggressive and refractory malignancy. Resistance toxicity limit drug efficacy. Herein, we report lower toxic higher effective miriplatin (MPt)-loaded liposome, LMPt, exhibiting totally different anti-cancer mechanism from previously reported platinum agents. Both in gemcitabine (GEM)-resistant/sensitive (GEM-R/S) pancreatic cells, LMPt exhibits prominent activity, led by faster cellular entry-induced larger accumulation of MPt. The level caveolin-1 (Cav-1)...
The activation of effector cells by bifunctional proteins to kill target has great potential in the treatment cancer. In this study, a recombinant fusion protein composed an anti‑idiotypic single chain mimicking CA125 connected with tuftsin artificial linker was constructed. found manifest number biological activities, including macrophages and stimulation T-cell response against Compared single‑chain Fv without tuftsin, showed stronger immunogenicity triggering humoral cellular immune...
5-Fluorouracil (5-FU) is a chemotherapeutic drug against many types of cancers, especially colorectal cancer. However, its short plasma half-life and serious adverse reactions limit wide clinical applications. To overcome these shortcomings, novel lipophilic 5-FU carbonate [XL-01, (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl tetradecyl carbonate] was designed, synthesized, encapsulated into liposome (LipoXL-01) by thin-film dispersion method through formulation screening...
Fibrosarcomas are highly aggressive malignant tumors. It is urgently needed to explore targeted drugs and modalities for more effective therapy. Matrix metalloproteinases (MMPs) play important roles in tumor progression metastasis, while several MMPs expressed fibrosarcomas. In addition, tissue inhibitor of metalloproteinase 2 (TIMP2) displays specific interaction with MMPs. Therefore, TIMP2 may an active role the development fibrosarcoma-targeting agents. current study, a TIMP2-based...
This study aims to explore and evaluate the antitumor efficacy of doxorubicin (DOX)-loaded liposomes containing novel tri-block polymer folate-poly (2-ethyl-2-oxazoline)-distearoyl phosphatidyl ethanolamine (F-PEOz-DSPE), compared with folate-polyethylene glycol-distearoyl (F-PEG-DSPE) offer an alternative for PEG decorated carriers. PEOz, a pH-sensitive polymer, exhibits similar solubility segmental flexibility PEG. In our previous study, PEOz was employed F-PEOz-DSPE which segmentally...
Acute myeloid leukemia (AML) is a hematological malignancy with high recurrence rate. The interaction of chemokine receptor 4/chemokine ligand 12 (CXCR4/CXCL12) mediates homing and adhesion AML cells in bone marrow, leading to minimal residual disease patients, which brings hidden danger for future recurrence. Ara-C nonselective chemotherapeutic agent against AML. Due its short half-life severe side effects, lipid-like derivative (AraN) was synthesized dual-function LipoAraN-E5 (135 nm,...
Background: Gemcitabine (Gem) is one of the first-line chemotherapy drugs for pancreatic cancer treatment. However, its short half-life in plasma and adverse effects limited broader application. Methods: A novel Gem derivative ( N4 -tetradecyloxycarbonyl gemcitabine, tcGem) was synthesized encapsulated into liposomes (LipotcGem) to overcome above shortcomings. Results: LipotcGem has been successfully formulated, with average size 115 nm, zeta potential values − 36 mV, encapsulation...