A5100716107- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Silk-based biomaterials and applications
- Electrochemical sensors and biosensors
- Advanced Biosensing Techniques and Applications
- Polymer Surface Interaction Studies
- Supramolecular Self-Assembly in Materials
- Electrospun Nanofibers in Biomedical Applications
- Cancer therapeutics and mechanisms
- 3D Printing in Biomedical Research
- Connective tissue disorders research
- Advanced Materials and Mechanics
- Immune Cell Function and Interaction
- Biochemical and Structural Characterization
- Molecular Sensors and Ion Detection
- Surface Modification and Superhydrophobicity
- biodegradable polymer synthesis and properties
- Analytical Chemistry and Chromatography
- Electrochemical Analysis and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Berberine and alkaloids research
- Tuberculosis Research and Epidemiology
Xiamen University
2024-2025
Chinese Academy of Sciences
2019-2025
Tsinghua University
2010-2025
Collaborative Innovation Center of Chemistry for Energy Materials
2024-2025
Dalian Institute of Chemical Physics
2020-2025
Beijing University of Civil Engineering and Architecture
2025
University of Jinan
2013-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Chinese Institute for Brain Research
2024
Wuhan University
2024
This paper describes BEAM, a general purpose Monte Carlo code to simulate the radiation beams from radiotherapy units including high‐energy electron and photon beams, 60 Co ortho‐voltage units. The handles variety of elementary geometric entities which user puts together as needed (jaws, applicators, stacked cones, mirrors, etc.), thus allowing simulation wide accelerators. is not restricted cylindrical symmetry. It incorporates powerful variance reduction techniques such range rejection,...
Abstract The gut microbiota is important in the pathogenesis of energy-metabolism related diseases. We focused on interaction between intestinal bacteria and orally administered chemical drugs. Oral administration berberine (BBR) effectively treats patients with metabolic disorders. However, because BBR exhibits poor solubility, its absorption mechanism remains unknown. Here, we show that converts into absorbable form dihydroberberine (dhBBR), which has an rate 5-fold animals. reduction to...
Berberine (BBR) has been confirmed to have multiple bioactivities in clinic, such as cholesterol-lowering, anti-diabetes, cardiovascular protection and anti- inflammation. However, BBR’s plasma level is very low; it cannot explain its pharmacological effects patients. We consider that the vivo distribution of BBR well bioactive metabolites might provide part explanation for this question. In study, liquid chromatography coupled ion trap time-of-flight mass spectrometry (LC/MSn-IT-TOF) with...
Abstract The development of biomedical glues is an important, yet challenging task as seemingly mutually exclusive properties need to be combined in one material, i.e. strong adhesion and adaption remodeling processes healing tissue. Here, we report a biocompatible biodegradable protein-based adhesive with high strengths. maximum strength reaches 16.5 ± 2.2 MPa on hard substrates, which comparable that commercial cyanoacrylate superglue higher than other adhesives by at least order...
Adhesive hydrogels have been developed for wound healing applications. However, their adhesive performance is impaired dramatically due to high swelling on wet tissues. To tackle this challenge, we fabricated a new type of non-swelling protein underwater and in vivo In soft material, the electrostatic complexation between supercharged polypeptides with oppositely charged surfactants containing 3,4-dihydroxylphenylalanine or azobenzene moieties plays an important role formation ultra-strong...
Tuning interfacial electric fields provides a powerful means to control electrocatalyst activity. Importantly, can modify adsorbate binding energies based on their polarizability and dipole moment, hence operate independently of scaling relations that fundamentally limit performance. However, implementation such strategy remains challenging because typical methods the field non-uniformly affects only minority active sites. Here we discover uniformly tunable modulation be achieved using model...
Complex coacervation enables important wet adhesion processes in natural and artificial systems. However, existed synthetic coacervate adhesives show limited properties, non-thermoresponsiveness, inferior biodegradability, greatly hampering their translations. Herein, by harnessing supramolecular assembly rational protein design, we present a temperature-sensitive bioadhesive fabricated through recombinant surfactant. Mechanical performance of the bioglue system is actively tunable with...
Abstract As a typical inflammatory disease with chronic pain syndromes, rheumatoid arthritis (RA) generally requires long‐term treatment frequent injection administration at 1–2 times per day, because common medications such as interleukin1 receptor antagonist (IL1ra) have poor bioavailability and very limited half‐life residence. Here novel strategy to fabricate nanotherapeutic formulations employing genetically engineered IL1ra protein complexes, yielding ultralong‐lasting bioefficacy is...
The utility of unfolded structural proteins with diverse sequences offers multiple potentials to create functional biomaterials. However, it is challenging overcome their defects for the development biological fibers a combination high strength and toughness. Herein, robust from recombinant protein consisting resilin supercharged polypeptide are fabricated via wet-spinning approaches. Particularly, highly ordered structures induced by supramolecular complexation significantly improve fiber's...
The inherently tenuous adhesion strength and limited environmental tolerance of supramolecular adhesives severely restrict their application scenarios. It is challenging for the development robust with extreme temperature tolerance. Herein, we report a new type temperature-resistant crown-ether-protein (CEP) adhesive by harnessing synergistic host-guest molecular interactions between engineered crown ether protein building blocks. outputs CEP demonstrate ultrahigh shearing ≈22 MPa over wide...
Abstract The manipulation of internal interactions at the molecular level within biological fibers is particular importance but challenging, severely limiting their tunability in macroscopic performances and applications. It thus becomes imperative to explore new approaches enhance fibers’ stability environmental tolerance impart them with diverse functionalities, such as mechanical recoverability stimulus-triggered responses. Herein, we develop a dynamic imine fiber chemistry (DIFC)...
Abstract The treatment of intervertebral disc degeneration (IVDD) using bone marrow mesenchymal stem cell‐derived exosomes has shown success in alleviating inflammation and restoring the extracellular matrix (ECM), however, challenges persist due to deficiency mechanical support controlled release. Herein, a carbon‐carbon double bond modified keratin (KeMA) is synthesized by 2‐isocyanatoethyl modification for wrapping. This injectable KeMA hydrogel, initiated biocompatible glucose/ glucose...
Two new compounds, coniferyl 9-O-[beta-D-apiofuranosyl(1-->6)]-O-beta-D-glucopyranoside (1) and sinapyl 9-O-[beta-d-apiofuranosyl(1-->6)]-O-beta-D-glucopyranoside (2), were isolated from the seeds of Punica granatum (pomegranate), together with five known 3,3'-di-O-methylellagic acid (3), 3,3',4'-tri-O-methylellagic (4), phenethyl rutinoside, icariside D1, daucosterol. The structures 1 2 elucidated by spectroscopic data analysis. Compounds 1-4 exhibited antioxidant activity, which was...