A5100420621- Neurological Disease Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA regulation and disease
- Peptidase Inhibition and Analysis
- Biochemical effects in animals
- Receptor Mechanisms and Signaling
- Protein Degradation and Inhibitors
- Cancer-related cognitive impairment studies
- Macrophage Migration Inhibitory Factor
- Medicinal Plant Pharmacodynamics Research
- Glutathione Transferases and Polymorphisms
- Sirtuins and Resveratrol in Medicine
- GDF15 and Related Biomarkers
- Traditional Chinese Medicine Analysis
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Curcumin's Biomedical Applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Xiyuan Hospital
2024
Capital Medical University
2008-2024
Xuzhou Medical College
2024
Capital University
2013-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2023
Xi'an Jiaotong University
2023
Harbin Medical University
2023
Second Affiliated Hospital of Harbin Medical University
2023
University of South China
2017
Silicosis is a serious silica-induced respiratory disease for which there currently no effective treatment. Irreversible pulmonary fibrosis caused by persistent inflammation the main feature of silicosis. As an underlying mechanism, acetylation regulated histone deacetylases (HDACs) are believed to be closely associated with and fibrosis. However, details mechanisms regulation acetylated modification in silicosis have yet sufficiently established. Furthermore, studies on efficient delivery...
Although surgery is an important treatment for laryngeal cancer, has a significant negative impact on the quality of life patients, and many patients have poor tolerance to surgery. Therefore, alternative chemotherapeutic drugs are research hotspot. Chidamide histone deacetylase inhibitor that selectively inhibits expression type I IIb deacetylases (1, 2, 3 10). It anticancer effect variety solid tumours. This study verified inhibitory chidamide carcinoma. We conducted cellular animal...
The small musculoaponeurotic fibrosarcoma (sMaf) proteins MafF, MafG, and MafK are basic region leucine zipper- (bZIP-) type transcription factors display tissue- or stimulus-specific expression patterns. As the oxidative stress reactive proteins, sMafs implicated in various neurological disorders. In present study, expressions of were investigated across five databases gathering transcriptomic data from 74 Alzheimer’s disease (AD) patients 66 controls Gene Expression Omnibus (GEO) database....
Lipoprotein lipase (LPL) expressed in macrophages plays an important role promoting the development of atherosclerosis or atherogenesis. MicroRNA-182 (miR-182) is involved regulation lipid metabolism and inflammation. However, it remains unclear how miR-182 regulates LPL atherogenesis.Methods Results:Using bioinformatics analyses a dual-luciferase reporter assay, we identified histone deacetylase 9 (HDAC9) as target gene miR-182. Moreover, upregulated expression by directly targetingHDAC9in...
This study aims to develop and validate SwinHS, a deep learning-based automatic segmentation model designed for precise hippocampus delineation in patients receiving hippocampus-protected whole-brain radiotherapy. By streamlining this process, we seek significantly improve workflow efficiency clinicians.
The neuropeptide galanin and its receptors have been found to protective effects on neurons. However, the role of astrocytes is still unclear. present study aimed at investigating viability cultured rat cortical after oxidative stress induced by H2O2 possible receptor signaling mechanisms involved. Treatment had significant against H2O2-induced toxicity in astrocytes. an upregulation phosphorylated extracellular signal-related kinase1/2 (pERK1/2) astrocytes, which was suppressed...
Fibrosarcomas are highly aggressive malignant tumors. It is urgently needed to explore targeted drugs and modalities for more effective therapy. Matrix metalloproteinases (MMPs) play important roles in tumor progression metastasis, while several MMPs expressed fibrosarcomas. In addition, tissue inhibitor of metalloproteinase 2 (TIMP2) displays specific interaction with MMPs. Therefore, TIMP2 may an active role the development fibrosarcoma-targeting agents. current study, a TIMP2-based...
Background: Nurr1, a member of the nuclear receptor superfamily transcription factors, is highly expressed in midbrain dopaminergic (DA) neurons. Ret tyrosine kinase (RTK) and critical signal transducing subunit receptors for glial cell line-derived neurotrophic factor (GDNF). Both Nurr1 play important roles development DA Purpose: To investigate possible correlation between on inducing expression hydroxylase (TH) neural precursor cells. Methods: Neural precursors isolated from rat embryonic...
<title>Abstract</title> <bold>Objective: </bold>Elevated plasma levels of S100A9 have been observed in patients with severe tuberculosis, further increases poor prognosis, suggesting that is a potential biomarker for disease progression and prognosis. However, the molecular mechanism underlying its remains unclear, highlighting importance exploring function. <bold>Methods:</bold> To investigate role we constructed gene knockout or overexpression models analyzed transcriptome changes THP-1...
This study aimed to investigate the potential mechanism and compatibility significance of Tanyu Tongzhi Formula in treating atherosclerosis(AS) mice based on transforming growth factor-β(TGF-β)/Smad2/3 signaling pathway. Eight C57BL/6J were as assigned a normal control group fed regular diet, while 35 ApoE~(-/-) same strain high-fat diet for 8 weeks establish an AS model. The model randomly divided into group, group(18.2 mg·kg~(-1)), Huatan(phlegm-resolving) group(10.4 Quyu(blood...
Diabetic peripheral arterial atherosclerosis is one of the important characteristics diabetic foot syndrome. Apolipoprotein (Apo A-IV) participates in various physiological processes, and animal studies have shown that it has roles anti-atherosclerosis, prevention platelet aggregation thrombosis. Apo A-IV glycosylation closely related to occurrence development atherosclerosis. This study aimed explore mechanism lesions caused by glycosylated A-IV. Type 2 diabetes mellitus (T2DM) T2DM with...
<p>Figure S4 shows that down-regulation of SAFB contributed to the aggressive features CRC cells through SAFB-TAK1-NF-κB axis.</p>
<p>Figure S5 shows that up-regulation of SAFB inhibited metastasis and angiogenesis in CRC through the SAFB-TAK1-NF-κB axis.</p>
It is reported that hypertension, diabetes mellitus, atherosclerosis leading to cerebral hypoperfusion, may be the risk of Alzheimer's disease (AD), and initiate pathological process AD. Cerebral blood hypoperfusion rat (10 months) model (2-VO) was used test activities β-/r-secretase, distribution levels Aβ1-40, Aβ1-42, APP, RAGE, LRP-1 NEP in cortex hippocampus. The rats were randomly divided into 10d, 30d, 90d 180d groups. (1) Escaping latency time swimming distance postponed initially...