A5100327425- Nuclear Receptors and Signaling
- Neuroscience and Neural Engineering
- Head and Neck Surgical Oncology
- RNA and protein synthesis mechanisms
- Muscle activation and electromyography studies
- Ferroptosis and cancer prognosis
- Lipid metabolism and disorders
- Pluripotent Stem Cells Research
- DNA Repair Mechanisms
- Advanced Memory and Neural Computing
- Peroxisome Proliferator-Activated Receptors
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Spinal Dysraphism and Malformations
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- MicroRNA in disease regulation
- EEG and Brain-Computer Interfaces
- Cerebrospinal fluid and hydrocephalus
- Renal and related cancers
Capital Medical University
2020-2021
Shantou University
2020
First Affiliated Hospital of Shantou University Medical College
2020
China Rehabilitation Research Center
2020
University of South China
2017
Ruijin Hospital
2012
Shanghai Jiao Tong University
2011-2012
Scripps Research Institute
2011
Abstract Background NURR1 (also named as NR4A2) is a member of the steroid/thyroid hormone receptor family, which can bind to DNA and modulate expression target genes. Previous studies have shown that essential for nigral dopaminergic neuron phenotype function maintenance, defects gene are possibly associated with Parkinson's disease (PD). Results In this study, we used new born Nurr1 knock-out mice combined Affymetrix genechip technology real time polymerase chain reaction (PCR) identify...
Lipoprotein lipase (LPL) expressed in macrophages plays an important role promoting the development of atherosclerosis or atherogenesis. MicroRNA-182 (miR-182) is involved regulation lipid metabolism and inflammation. However, it remains unclear how miR-182 regulates LPL atherogenesis.Methods Results:Using bioinformatics analyses a dual-luciferase reporter assay, we identified histone deacetylase 9 (HDAC9) as target gene miR-182. Moreover, upregulated expression by directly targetingHDAC9in...
Ischemia-reperfusion injury (IRI) remains an inevitable and major challenge in renal transplantation. The current study aims to obtain deep insights into underlying mechanisms seek prognostic genes as potential therapeutic targets for IRI (RIRI).After systematically screening the Gene Expression Omnibus (GEO) database, we collected gene expression profiles of over 1,000 specimens from 11 independent cohorts. Differentially expressed (DEGs) were identified by comparing allograft kidney...
This study aims to investigate the protection of dexmedetomidine (Dex) against pulmonary ischemia-reperfusion injury (PIRI) in mouse model and reveal mechanism hypoxia reoxygenation (H/R)-induced vascular endothelial cells (MPVECs). The lung wet-to-dry weight ratio, histopathological features, malondialdehyde (MDA) concentrations were measured. H/R-induced MPVECs exposed Dex, cell viability, apoptosis protein expressions assessed by Cell Counting Kit-8 (CCK8) assay, flow cytometry western...
Subdural effusion is a common complication that occurs after decompressive craniectomy. According to the endoscopy results, formation mechanism of subdural craniectomy was discussed.The morphological structure in skull defects observed with endoscopy, and endoscopic-assisted surgery performed for effusion.From January 2018 March 2020, 19 cases repair treatment were performed. The external wall capsule kept intact during operation, surgical procedure under an endoscope could be observed,...