A5066262614- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Adaptive optics and wavefront sensing
- Astronomy and Astrophysical Research
- Pancreatic function and diabetes
- Optical Systems and Laser Technology
- Advanced Measurement and Metrology Techniques
- Stellar, planetary, and galactic studies
- Radio Astronomy Observations and Technology
- Computational Drug Discovery Methods
- Congenital gastrointestinal and neural anomalies
- Advanced optical system design
- Mass Spectrometry Techniques and Applications
- Robotic Mechanisms and Dynamics
- Metabolism, Diabetes, and Cancer
- Piezoelectric Actuators and Control
- Biochemical Analysis and Sensing Techniques
- Ion channel regulation and function
- Glycosylation and Glycoproteins Research
- Antenna Design and Optimization
- Nuclear Receptors and Signaling
- Chemical Synthesis and Analysis
- Muscle activation and electromyography studies
- PI3K/AKT/mTOR signaling in cancer
Shanghai Institute of Materia Medica
2016-2025
Chinese Academy of Sciences
2016-2025
National Center for Drug Screening
2016-2025
University of Chinese Academy of Sciences
2017-2025
Institute of Deep-Sea Science and Engineering
2021-2025
Nanjing University of Chinese Medicine
2023-2025
Institute of Physics
2024
Huazhong University of Science and Technology
2014-2024
Union Hospital
2013-2024
Nanjing Institute of Astronomical Optics & Technology
2008-2024
The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST's design allows both large aperture (effective of 3.6 m–4.9 m) and wide field view (FOV) (5°). It has an innovative active configuration which continuously changes mirror's surface that adjusts during observation process combines thin deformable mirror optics with segmented optics. Its primary (6.67 m × 6.05 (5.74m 4.40m) are...
Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human physiology. Understanding receptor activation mechanism is critical for discovering novel therapeutics since about one-third all marketed drugs target members this family. GPCR an allosteric process that couples agonist binding to G-protein recruitment, with the hallmark outward movement transmembrane helix 6 (TM6). However, what leads TM6 and key residue level changes remain less well understood. Here, we...
Aberrant protein misfolding may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS) but detailed mechanisms are largely unknown. Our previous study has shown that autophagy is altered in mouse model ALS. In present study, we systematically investigated correlation autophagic alteration with motor neurons (MNs) degeneration ALS mice. We have demonstrated marker LC3-II markedly and specifically increased spinal cord MNs Electron microscopy immunochemistry studies vacuoles...
The parathyroid hormone receptor-1 (PTH1R) is a class B G protein-coupled receptor central to calcium homeostasis and therapeutic target for osteoporosis hypoparathyroidism. Here we report the cryo-electron microscopy structure of human PTH1R bound long-acting PTH analog stimulatory protein. peptide adopts an extended helix with its amino terminus inserted deeply into transmembrane domain (TMD), which leads partial unwinding carboxyl 6 induces sharp kink at middle this allow couple In...
This paper describes the data release of LAMOST pilot survey, which includes reduction, calibration, spectral analysis, products and access. The accuracy released information about FITS headers spectra are also introduced. set 319 000 a catalog these objects.
Significance Although the overwhelming majority of COVID-19-related deaths are due to respiratory failure, little is known about host response SARS-CoV-2 in lung parenchyma. By profiling and colon transcriptome proteome nine patients who died COVID-19 during first wave pandemic Wuhan, China, we obtained molecular insights into severe infection. Interestingly, all samples had a low viral burden, finding that suggests patients’ may be uncontrolled inflammatory processes rather than an active...
Abstract Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several multi-targeting agonists at GIPR, GLP-1R or GCGR, developed maximize metabolic benefits with reduced side-effects, are in clinical trials treat type 2 diabetes obesity. To elucidate the molecular mechanisms which tirzepatide, a GIPR/GLP-1R dual agonist, peptide 20, GIPR/GLP-1R/GCGR triagonist, manifest their...
We report a novel coaxial antenna for hepatic microwave ablation. This device uses floating sleeve, that is, metal conductor electrically isolated from the outer connector of body, to achieve highly localized specific absorption rate pattern is independent insertion depth. sleeve dipole has low power reflection in 2.4-GHz IMS band. Ex vivo experiments confirm our numerical simulation results. Index Terms-Ablation, aperture antennas, finite element methods, heating.
Although it is well established that embryonic stem (ES) cells have the potential to differentiate into dopamine neurons, molecular basis of this process, particularly role microRNAs (miRNAs), remains largely unknown. Here we report miR-132 plays a key in differentiation neurons by directly regulating expression Nurr1 (also known as nuclear receptor subfamily 4 group A member 2; Nr4a2). We constructed mouse ES cell line CGR8, which stably expresses GFP under tyrosine hydroxylase (TH)...
Recent evidence shows that altered microRNA-9 (miR-9) expression is implicated in the progression of gastric cancer. However, exact roles and underlying mechanisms miR-9 proliferation, invasion metastasis cancer still remain unknown. In this study, was found to be down-regulated inversely correlated with cyclin D1 v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) tissues cell lines. Bioinformatics analysis revealed putative binding sites 3′-untranslated regions (3′-UTR) Ets1 mRNA....
Choosing a partner that fits G protein–coupled receptors (GPCRs) are responsible for transducing diverse signals from outside to inside cells. This process requires specificity both in ligand binding GPCRs and coupling between their intracellular partners, proteins. Qiao et al. determined the structure of human glucagon receptor (GCGR), type B GPCR, bound one two heterotrimeric proteins, s or i1 . GCGR mainly through , structures provide basis this specificity. Conformational changes GCGR,...
Aim: Nanoparticles are easier to pass through cell membranes, and they considered be the ideal biocompatible mechanically stable platforms for supporting stem growth differentiation. The aim of this study is determine effects carbon nanotubes (CNTs), graphene oxide (GO) (GR) on dopamine neural differentiation mouse embryonic cells (ESCs). Materials & methods: GO was prepared according a modified Hummers method. GR synthesized by reduction via L-ascorbic acid as reductant in an aqueous...
Class B G protein-coupled receptors are composed of an extracellular domain (ECD) and a seven-transmembrane (7TM) domain, their signalling is regulated by peptide hormones. Using hybrid structural biology approach together with the ECD 7TM crystal structures glucagon receptor (GCGR), we examine relationship between full-length conformation ligand binding. Molecular dynamics (MD) disulfide crosslinking studies suggest that apo-GCGR can adopt both open closed associated extensive contacts...
Abstract Cholecystokinin A receptor (CCK R) belongs to family G-protein-coupled receptors and regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive drug target for gastrointestinal metabolic diseases. One distinguishing feature of CCK R its ability interact with a sulfated ligand couple divergent G-protein subtypes, including G s , i q . However, the basis coupling promiscuity recognition remains unknown. Here, we present three cryo-electron microscopy...