A5080295941- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Sleep and Wakefulness Research
- Glycogen Storage Diseases and Myoclonus
- Genetics and Neurodevelopmental Disorders
- Transcranial Magnetic Stimulation Studies
- Head and Neck Surgical Oncology
- Pharmacological Effects and Toxicity Studies
- Neural and Behavioral Psychology Studies
- Vascular Procedures and Complications
- Neonatal and fetal brain pathology
- Meningioma and schwannoma management
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Cognitive Abilities and Testing
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Attention Deficit Hyperactivity Disorder
- Venous Thromboembolism Diagnosis and Management
- Restless Legs Syndrome Research
- Substance Abuse Treatment and Outcomes
Capital Medical University
2012-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Peking University
2017-2024
Xuan Wu Hospital of the Capital Medical University
2012-2024
Beijing Friendship Hospital
2024
Army Medical University
2022-2023
China Rehabilitation Research Center
2015-2021
Peking University Sixth Hospital
2017-2021
Liaoning Normal University
2021
Dalian University
2021
This study was designed to evaluate the therapeutic effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on patients with refractory partial epilepsy.Sixty-four focal epilepsy were screened and 60 randomly divided into two groups by intensity: 90% (group 1) or 20% 2) resting motor threshold (rMT). Seizure frequency interictal EEG epileptic discharges compared between baseline follow-up periods.Seizures significantly decreased following 2-weeks high intensity (90% rMT)...
Evidence is sparse and inconclusive on the association between long-term fine (≤2.5 μm) particulate matter (PM
Network properties can be estimated using functional connectivity MRI (fcMRI). However, regional variation of the fMRI signal causes systematic biases in network estimates including correlation attenuation regions low measurement reliability. Here we computed spatial distribution fcMRI reliability longitudinal datasets and demonstrated how pre-estimated maps correct for attenuation. As a test case reliability-based correction default network, where was significantly lower than average medial...
The connectivity architecture of the human brain varies across individuals. Mapping functional anatomy at individual level is challenging, but critical for basic neuroscience research and clinical intervention. Using resting-state connectivity, we parcellated systems in an "embedding space" based on characteristics common population, while simultaneously accounting variability cortical distribution units. patterns observed data were mapped embedding space maps aligned A clustering algorithm...
Background:Oxytocin, a neurohypophyseal neuropeptide, is potential mediator and regulator of drug addiction. However, the cellular mechanisms oxytocin in seeking remain unknown.
Abstract Background Little is known about the effects of maintaining healthy sleep patterns on frailty transitions. Methods Based 23,847 Chinese adults aged 30–79 in a prospective cohort study, we examined associations between and Healthy included duration at 7 or 8 h/d, without insomnia disorder, no snoring. Participants who persisted with pattern both surveys were defined as scored one point. We used 27 phenotypes to construct index three statuses: robust, prefrail, frail. Frailty...
To observe and measure the morphological temporal evolutionary features of hypersynchronous (HYP) pattern in mesial seizure. The HYP patterns during preictal interictal states 16 epileptic patients were analyzed. wave components transients firstly observed measured. dynamic deformations parameter changes further analyzed along preictal-ictal axis. difference emergence rate typical spike periods was also compared. invariably composed slow-wave proper, sharp post-slow component among studied...
Background:The Mild Behavioral Impairment Checklist (MBI-C), a screening scale for neuropsychiatric symptom evaluation, facilitates Alzheimer's disease (AD) screening. However, its validity and reliability use as an AD tool have not been determined. Objective:To develop screenin g suitable the Chinese population. Methods:The MBI-C was translated into back-translated with original author's consent. Forty-six patients, attending Xuanwu hospital memory clinic, 50 sex- education-matched controls...
Seventeen refractory partial epilepsy patients were enrolled in an open-label study to evaluate the antiepileptic effect of low-frequency repetitive transcranial magnetic stimulation (rTMS). Seven had not obtained seizure-free status after epileptogenic focus resection surgery before they study. All treated with rTMS which included 3 sessions per day (0.5 Hz, 90% RMT and 500 pulses each session) lasted for 2 weeks. Seizure frequency, seizure days epileptic discharges EEG before, during...
Objectives Knowledge of the urinary metabolomic profiles healthy children and adolescents plays a promising role in field pediatrics. Metabolomics has also been used to diagnose disease, discover novel biomarkers, elucidate pathophysiological pathways. Attention-deficit/hyperactivity disorder (ADHD) is one most common psychiatric disorders childhood. However, large-sample studies with ADHD are relatively rare. In this study, we aimed identify specific biomarkers for diagnosis by profiling....
BackgroundPrevious observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of on stroke.MethodsBased 82,339 unrelated individuals with qualified genotyping data Asian descent from China Kadoorie Biobank (CKB), we conducted Mendelian randomization (MR) analysis Genetic variants identified in genome-wide association (GWAS) CKB UK (UKB) were selected for constructing genetic risk scores (GRS). A two-stage method was applied...
To explore the structural brain abnormality and its relationship with neuropsychological disorders electroclinical characteristics in juvenile myoclonic epilepsy (JME) patients.
Seizures arising from the precuneus are rare, and few studies have aimed at characterizing clinical presentation of such seizures within anatomic context frontoparietal circuits. We to characterize electrophysiological properties features based on data stereoelectroencephalography (SEEG).The present retrospective study included 10 patients with medically intractable epilepsy, all whom were diagnosed precuneal epilepsy via (SEEG) Yuquan Hospital Xuan Wu between 2014 2016. Clinical semiology,...
Abstract The brain networks undergo functional reorganization across the whole lifespan, but dynamic patterns behind remain largely unclear. This study models dynamics of spontaneous activity large-scale using hidden Markov model (HMM), and investigates how it changes with age on two adult lifespan datasets 176/157 subjects (aged 20–80 years). Results for both showed that 1) older adults tended to spend less time a state where default mode network (DMN) attentional show antagonistic...
Background and purpose: Serotoninergic dysfunction was reported to be involved in aetiology of temporal lobe epilepsy (TLE). Serotonin (5‐HT) is actively cleared from synaptic cleft by serotonin transporter (5‐HTT). We investigated the association between three common polymorphisms 5‐HTT gene, which may influence gene expression or function, risk for TLE. Methods: Three hundred thirty‐four patients with TLE four eighty‐seven non‐epileptic control subjects Han Chinese origin were enrolled...