Xiaohui Sun
A5031600643- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Antibiotic Use and Resistance
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Patient Satisfaction in Healthcare
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Healthcare Systems and Technology
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Blood Pressure and Hypertension Studies
- Cancer Diagnosis and Treatment
- Healthcare Systems and Reforms
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Medical Imaging Techniques and Applications
- Cardiovascular Health and Risk Factors
- Health disparities and outcomes
- Cancer Risks and Factors
- Genetic Associations and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Machine Learning in Healthcare
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2025
Zhejiang Chinese Medical University
2020-2024
University of Science and Technology of China
2018-2024
Peking University
2023-2024
King's College London
2018-2024
Qingdao Municipal Center for Disease Control and Prevention
2018-2023
Peking University People's Hospital
2023
Southwest Medical University
2023
First Affiliated Hospital of Henan University of Science and Technology
2023
Guangdong Medical College
2010-2021
Abstract Background A major obstacle to successful coronavirus disease (COVID-19) vaccine rollout is hesitancy. Acceptance of and preferences for COVID-19 vaccination among healthcare workers (HCWs) critical, because they are a key target group programs, also highly influential uptake in the wider population. This study sought comparatively determine acceptance preference HCWs general Methods An Internet-based, region-stratified discrete-choice experiment was conducted 352 189 population...
Acute Coronavirus Disease 2019 (COVID-19) has been associated with new-onset cardiovascular disease (CVD) and diabetes mellitus (DM), but it is not known whether COVID-19 long-term impacts on cardiometabolic outcomes. This study aimed to determine the incidence of new DM CVDs are increased over 12 months after compared matched controls. We conducted a cohort from 2020 2021 analysing electronic records for 1,356 United Kingdom family practices population 13.4 million. Participants were...
Background. Leukemia is a common malignancy that has four main subtypes and threat to human health. Understanding the epidemiological status of leukemia its globally important for allocating appropriate resources, guiding clinical practice, furthering scientific research. Methods. Average annual percentage changes (AAPCs) were calculated estimate change trends age-standardized rates (ASRs) from 1990 2019 in 204 countries territories. The risk factors death disability-adjusted life-year...
Little evidence from large-scale cohort studies exists about the relationship of solid fuel use with hospitalization and mortality major respiratory diseases.To examine associations risks acute chronic diseases.A study 277,838 Chinese never-smokers no prior diseases at baseline. During 9 years follow-up, 19,823 first episodes or deaths diseases, including 10,553 lower disease (CLRD), 4,398 obstructive pulmonary (COPD), 7,324 infection (ALRI), were recorded. Cox regression yielded adjusted...
In 2015, the World Health Organization (WHO) included spread through air space (STAS) as a new invasive mode of lung cancer. As cancer dissemination, STAS has significant and negative impact on patient prognosis. The surgical approach well lymph node dissection (LND) for STAS-positive patients is currently unclear. aim this study was to investigate different approaches LND prognosis with ≤2 cm stage IA adenocarcinoma (LUAD). This also investigated possible relationship between micropapillary...
Abstract Background Little is known about the effects of maintaining healthy sleep patterns on frailty transitions. Methods Based 23,847 Chinese adults aged 30–79 in a prospective cohort study, we examined associations between and Healthy included duration at 7 or 8 h/d, without insomnia disorder, no snoring. Participants who persisted with pattern both surveys were defined as scored one point. We used 27 phenotypes to construct index three statuses: robust, prefrail, frail. Frailty...
Background The principal aim of malignant pleural effusion (MPE) management is to improve health-related quality life (HRQoL) and symptoms. Methods In this open-label randomised controlled trial, patients with symptomatic MPE were randomly assigned either indwelling catheter (IPC) insertion the option talc pleurodesis or chest drain pleurodesis. primary end-point was global health status, measured 30-item European Organisation for Research Treatment Cancer Quality Life Core Questionnaire...
Objective To analyse individual-patient electronic health records to evaluate changes in antibiotic (AB) prescribing England for different age groups, male and female subjects, by indications from 2014 2017. Methods Data were analysed 102 general practices that contributed data the UK Clinical Practice Research Datalink (CPRD) Prescriptions all ABs broad-spectrum β-lactam evaluated. Relative rate reductions (RRR) estimated a random-effects Poisson model, adjusting age, gender, practice....
Objectives We aimed to evaluate recording of antibiotic prescribing from two primary care electronic health record systems. Design Cohort study. Setting UK general practices contributing the Clinical Practice Research Datalink (CPRD) databases: CPRD GOLD (Vision data) and Aurum (EMIS data). English were analysed as a subgroup, all located in England. Participants 158 305 patients randomly sampled 160 394 GOLD. Outcome measures Antibiotic prescriptions 2017 identified. Age-standardised...
There is uncertainty about the optimum sleep duration for risk of different subtypes stroke and ischaemic heart disease.The present analyses involved 409,156 adults in China Kadoorie Biobank study without a prior history coronary disease or insomnia symptoms. The mean age participants was 52 years 59% were women. Self-reported including daytime napping recorded using questionnaire. adjusted hazard ratios (HRs) outcomes associated with estimated by Cox proportional hazards after adjustment...
Estimate predictive associations of marital status with social dysfunction in schizophrenia patients. 817 patients lived the community Dongguan, Guangdong province, China, were investigated Social Disability Screening Schedule (SDSS) during a three-month period (1.2010–3.2010). The demographic data harvested. χ2 test, t and fisher's exact used for comparisons between groups, as appropriate. Multinomial logistic regression (MLR) was to analyze variables grading dysfunctions. study group...
Background Efforts to reduce unnecessary antibiotic prescribing have coincided with increasing awareness of sepsis. We aimed estimate the probability sepsis following infection consultations in primary care when antibiotics were or not prescribed. Methods and findings conducted a cohort study including all registered patients at 706 general practices United Kingdom Clinical Practice Research Datalink, 66.2 million person-years follow-up from 2002 2017. There 35,244 first episodes (17,886,...
Controversy persists about the relationship of blood pressure with cardiovascular diseases (CVD) in diabetes and associated disease burden. We assessed these associations among Chinese adults type 2 (T2D).
BackgroundPrevious observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of on stroke.MethodsBased 82,339 unrelated individuals with qualified genotyping data Asian descent from China Kadoorie Biobank (CKB), we conducted Mendelian randomization (MR) analysis Genetic variants identified in genome-wide association (GWAS) CKB UK (UKB) were selected for constructing genetic risk scores (GRS). A two-stage method was applied...
Increasing hospital admissions for pneumonia have been reported recently but it is not known whether incidence rates increased in the community. To determine of primary care United Kingdom from 2002 to 2017, an open cohort study was conducted using electronic health records UK Clinical Practice Research Datalink. Clinically diagnosed pneumonia, influenza pleural infection and clinically suspected defined as chest treated with antibiotics, were evaluated. Age-standardised age-specific...
Abstract Systemic inflammation, reflected by increased plasma concentrations of C-reactive protein (CRP) and fibrinogen, is associated with risk coronary heart disease, but its relevance for stroke types remains unclear. Moreover, evidence limited in non-European populations. We investigated associations CRP fibrinogen risks incident major events (MCE), ischemic (IS) intracerebral hemorrhage (ICH) a cohort Chinese adults. A nested case-control study within the prospective China Kadoorie...
Objective This study evaluated whether serious bacterial infections are more frequent at family practices with lower antibiotic prescribing rates. Design Cohort study. Setting 706 UK in the Clinical Practice Research Datalink from 2002 to 2017. Participants 10.1 million registered patients 69.3 patient-years’ follow-up. Exposures All prescriptions, subgroups of acute and repeat proportion prescriptions associated specific-coded indications. Main outcome measures First episodes infections....
To compare the short-term outcomes and postoperative quality of life in patients with esophageal cancer between inflatable videoasisted mediastinoscopic transhiatal esophagectomy (IVMTE) minimally invasive Mckeown (MIME), to evaluate value IVMTE surgical treatment cancer.A prospective, nonrandomized study was adopted. A total 60 after MIME December 2019 January 2022 were included. Among them, 30 underwent MIME. Shortterm (including operation time, intraoperative blood loss, drainage 3 days,...
The efficacy and toxicity of combined paclitaxel gemcitabine was evaluated in 54 chemotherapy-naive patients with metastatic non-small cell lung cancer (NSCLC). Gemcitabine i.v. 1000 mg/m(2)was administered on days 1 8 200 mg/m(2)as a continuous 3-hour infusion day 1. Treatment repeated every 21 days. Patients had median age 53 years. ECOG performance status 0 or 48 patients. 41 (75.9%) initial stage IV disease; histology mainly adenocarcinoma (46.3%). 2 (4.3%) achieved complete response 15...