MicroRNAs have an important role in diverse biological processes including tumorigenesis. MiR-223 has been reported to be deregulated several human cancer types. However, its not functionally characterized lung squamous cell carcinoma (LSCC). The following study investigates the of miR-223-3p LSCC growth and metastasis underlying mechanism. MicroRNA profiling analyses were conducted determine differential miRNAs expression levels tumor tissues that successfully formed xenografts...

Abstract The paired‐like homeodomain transcription factor 2 ( PITX2 ), a downstream effector of wnt/β‐catenin signaling, is well known to play critical role during normal embryonic development. However, the possible involvement in human tumorigenesis remains unclear. In this study, we extend its function esophageal squamous cell carcinoma (ESCC). real‐time PCR, Western blotting and immunohistochemistry (IHC) methods were applied examine expression pattern two different cohorts ESCC cases...

Background In this study, we investigated the relationship between chronic cough and clinicopathological features in postoperative patients with non‐small cell lung cancer (NSCLC) evaluated effectiveness of acupuncture therapy for treatment NSCLC. Methods We retrospectively 171 NSCLC who received lobectomy at our center September 2017 February 2018. The Mandarin Chinese version Leicester Cough Questionnaire (LCQ‐MC) was used to evaluate degree patients. Postoperative assessed by a visual...

The aim of this study was to evaluate the effect uniportal and three-portal VATS in lung cancer patients on postoperative short-term quality life (QOL).A single-center, prospective, nonrandomized performed who underwent or video-assisted thoracoscopic surgery (VATS) lobectomy systemic mediastinal lymph node dissection. QOL measured before at baseline one, two, four, eight weeks after operation. data normal distribution were indicated by mean ± standard deviation, independent sample t-test...

Small cell carcinoma of the esophagus (SCCE) is a rare, highly aggressive tumor characterized by early dissemination and poor prognosis. Surgery, chemotherapy, radiotherapy have been used alone or in combination for treatment this rare disease. The aim retrospective study was to analyze role surgery management limited-stage SCCE at high-volume center. We retrospectively evaluated 73 patients with who received an esophagectomy our center from January 1994 December 2011. clinical...

To compare the short-term outcomes and postoperative quality of life in patients with esophageal cancer between inflatable videoasisted mediastinoscopic transhiatal esophagectomy (IVMTE) minimally invasive Mckeown (MIME), to evaluate value IVMTE surgical treatment cancer.A prospective, nonrandomized study was adopted. A total 60 after MIME December 2019 January 2022 were included. Among them, 30 underwent MIME. Shortterm (including operation time, intraoperative blood loss, drainage 3 days,...

Due to their high biocompatibility, spatial resolution and adjustable size morphology, magnetic nanoparticles have become the most promising nanomaterials for clinical application in imaging drug delivery treatment of cancers.

Acupuncture has achieved good results in the treatment of cough, asthma, chronic obstructive pulmonary disease (COPD) and other lung diseases, but mechanism associated with acupuncture cough induced by surgery is unknown. We investigated whether therapy could improve symptoms after through cyclic-AMp dependent protein kinase A (PKA)/cyclic-AMp C (PKC) regulation transient receptor potential vanilloid-1 (TRPV1) signaling pathway.The guinea pigs were divided into 5 groups: Sham operation Group...

The impact of the number negative lymph nodes (LNs) on survival in patients with esophageal cancer remains a controversial issue. This study investigated association between resected LNs and prognosis node-negative carcinoma.A retrospective review was performed data 429 who underwent esophagectomy modern two-field lymphadenectomy for treatment January 1998 December 2008. Histopathology showed no LN involvement patient sample. prognostic clinicopathological factors were analyzed.The overall...

Background To investigate the regulatory mechanism behind miR‐34a‐altered Axl levels in non‐small‐cell lung cancer (NSCLC) with gefitinib‐acquired resistance. Methods The expression of miR‐34a, Axl, Gas6 and related downstream signaling proteins EGFR mutant NSCLC cell lines were determined by qRT‐PCR Western blot; PC9‐Gef‐miR‐34a HCC827‐Gef‐miR‐34a cells established transfecting parent a miR‐34a overexpressing virus, then channel‐related also compared drug‐resistant strains. survival rate...

Abstract Background To investigate the uniportal video‐assisted thoracoscopic surgery (VATS) technique and safety of non‐small cell lung cancer (NSCLC) patients treated with three‐port VATS. Methods We retrospectively evaluated 146 consecutive NSCLC who underwent VATS lobectomy between January 2018 May 2018. The general clinical date, perioperative data life quality were individually compared analyzed two groups. Results Intraoperative blood loss was significantly lower in than group ( p =...

Introduction Segmentectomy is widely used for early-stage lung cancer presenting as single or multiple ground-glass opacities (GGOs). Precise segmentectomy the recommended procedure in China. However, clinically, most routine segmentectomies are performed using only high-resolution computed tomography (CT). The aim of this study was to evaluate effect two approaches GGOs lung. Methods From January 2020 September 2020, 55 precise with real-time guidance 3D reconstruction and 343 patients were...

Abstract Background Minimally invasive approaches are increasingly being used in oesophagectomy. The aim of this study was to compare the short‐term clinical outcomes minimally I vor– L ewis oesophagectomy ( MIILE ) technique with those open OILE technique. Methods We identified 131 patients who underwent combined thoracoscopy and laparoscopy. These were compared 248 between J anuary 2012 D ecember 2013. Results produced similar post‐operative hospital mortality 2.3 versus 2%; P = 1.000)....

Background To evaluate the systematic mediastinal lymph node (LN) dissection outcomes and conversion rates of uniportal video‐assisted thoracoscopic surgery (UVATS). Methods Patients with non‐small‐cell lung cancer who underwent (VATS) LN between January 2015 2017 were retrospectively reviewed. We categorized patients into two groups according to different surgical approaches. Patients' clinical data collected compared. The index estimated benefit from was used therapeutic value for each...

Background We investigated preoperative and postoperative TRPV1, bradykinin (BK), prostaglandin e‐2 (PGE2) levels in patients who underwent lung cancer surgery evaluated the correlations between these development of acute or chronic cough after surgery. Methods 60 with non‐small cell lobectomy at our center August October 2018. BK, PGE2 were determined by enzyme‐linked immunosorbent assay was assessed using visual analog scale (VAS). Results The serum PEG2 significantly higher than ( P <...

Recently, the detectable rate of ground-glass opacity (GGO ) was significantly increased, a appropriate diagnosis before clinic treatment tends to be important for patients with GGO lesions. The aim this study is validate ability mean computed tomography (m-CT) value predict tumor invasiveness, and compared other measurements such as Max CT value, size, solid size C/T ratio (consolid/tumor ratio, C/T) find out best measurement invasiveness.A retrospective conducted 129 who recieved lobectomy...

Lung squamous cell carcinoma (LSCC), the second most common type of lung cancer, has received limited attention. Patient-derived tumor xenografts (PDTXs) are useful preclinical models to reproduce diverse heterogeneity but it is important identify potential variations during their establishment. A total 18 PDTXs were established from 37 surgical specimens and 16 serially passaged third generation. Second- third-generation had a faster growth rate in mice. The implantation success was...

Objective: To evaluate the effect of postoperative short-term quality life between uniportal and three portal video-assisted thoracic surgery for radical lung cancer resection. Methods: The perioperative data 120 patients received resection were analyzed from September to November 2017 at Department Thoracic Surgery, First Affiliated Hospital University Science Technology China. There 64 male 56 female aging (62±10) years (ranging 28 82 years). 60 cases (uniportal group) (three-portal...

This study investigated the relationship between neutrophil-to-lymphocyte ratio (NLR) and clinicopathological features prognosis in patients with postoperative esophageal squamous cell carcinoma (ESCC).The preoperative NLR was evaluated 419 who underwent esophagectomy for ESCC. A receiver operating characteristic (ROC) curve plotted to verify accuracy of predicting survival. Correlation characteristics analyzed using χ2 test. Prognostic influence calculated by Kaplan-Meier method difference...

Through the comparative analysis of acute and chronic pain postoperative between single port triple video-assisted thoracic surgery to seek better method which can reduce incidence in patients with lung cancer.Data 232 who underwent -VATS (n=131) or VATS (n=101) for non-small cell cancer (NSCLC) on January 1, 2016 June 30, 2017 our hospital were analyzed. The clinical operative data assessed, numeric rating scale (NRS) was used evaluate mean score 1th, 2th, 3th, 7th, 14th days, 3th months...

Currently, there are many reports on the advantages of three portal video-assisted thoracic surgery (VATS) in treatment lung cancer, but few comparison between uniportal and surgery. In this study, we aimed to evaluate recent curative effect postoperative short-term quality life for non-small cell cancer.We retrospectively evaluated 266 patients with NSCLC who underwent intended VATS lobectomy by a single surgical team our ward January 2016 August 2017. The general clinical date,...

This study aimed to investigate the effect of type 2 diabetes mellitus on survival patients with non-small cell lung cancer (NSCLC). We retrospectively analyzed NSCLC who had undergone radical surgery from January 2011 December 2014 in Anhui Medical University affiliated Provincial Hospital. Kaplan-Meier plots, log-rank tests, and Cox proportional hazards regression models were used describe overall NSCLC. A total 769 enrolled, including 126 diabetic group 643 nondiabetic group. The one,...