Esophageal squamous cell carcinoma (ESCC) is a common malignancy with poor prognosis. The drug resistance compromises the efficacy of chemotherapy for ESCC. Long non-coding RNA taurine upregulated gene 1 (TUG1) has been identified as promoter cancer progression and in many malignancies. However, exact role TUG1 ESCC remains unclear. In this study, we showed that expression TE-1-derived cisplatin (DDP)-resistant (TE-1/DDP) cells was higher than TE-1 cells. Furthermore, promoted DDP TE-1/DDP...

Portulaca oleracea is a well-known species for traditional medicine and food homology in Taiwan. In medicine, P. also used to treat gastrointestinal disorders, liver inflammation, fever, severe headaches. We investigated antioxidant, anti-tyrosinase, anti-α-glucosidase activities of various solvent extracts major bioactive components from oleracea. Ethanol acetone showed potent DPPH, ABTS, hydroxyl radical scavenging activities. Chloroform n-hexane displayed significant superoxide activity....

Microfluidics has been the most promising platform for drug screening with a limited number of cells. However, convenient on-chip preparation wide range concentrations remains large challenge and restricted acceptance microfluidics in precision medicine. In this paper, we report digital microfluidic system an innovative control structure chip design dispensing to generate that span three four orders magnitude, enabling single or combinatorial multi-drug simple electronic control....

Through the portrayal of rural left-behind children in Chinese state media, this study investigates evolution narratives and societal consequences. The research seeks to uncover its media depiction how these constitute cultural policy priorities. A Systematic Literature Review (SLR) was carried out using a qualitative approach order analyze 20 peer-reviewed studies. Thematic analysis highlighted major shifts moving from early portrayals that favored idea material deprivation more recent...

The final coverage and associated performance of a single frequency networks (SFNs) is joint result the properties all transmitters in SFN. Due to large number parameters involved process, finding right configuration quite complex. purpose this paper find optimal SFN network configurations for second generation digital terrestrial broadcast system (DVB-T2). Offering more options than its predecessor DVB-T, DVB-T2 allows networks. However, self-interference SFNs gives rise restrictions on...

Introduction: Otitis media with effusion (OME) is a common middle ear disease in children. The associated conductive hearing loss major concern for health professionals. aim of the present study was to describe configuration pure tone audiograms children OME and design statistical stratification algorithm facilitate profiling OME.Methods: School age were recruited. Bone air conduction thresholds obtained using standard procedures. Hierarchical cluster analysis employed determine audiometric...

The discussion around different network architectures, namely high power/high tower (HPHT) versus low power/low (LTLP) is currently a hot topic in international fora. This paper presents the results of study to compare coverage, number sites, and deployment/maintenance costs associated three configurations (HPHT only, LTLP mixed HPHT + LTLP) for rooftop, mobile, portable indoor/outdoor digital terrestrial television service delivery. analysis has been based on practical planning scenario....

Ascorbic acid (AA) electrochemical sensor upon modification with porous g-C3N4(PCN)/Poly (3,4-ethylenedioxythiophene) (PEDOT) composite was constructed by a facile co-deposited method. The obtained PCN bearing more oxygen-containing functional groups demonstrates excellent dispersion. Transmission electron microscopy (TEM) and Raman spectroscopy were performed to evaluate the structure morphology of PCN/PEDOT composite. Detailed behaviors AA investigated cyclic voltammetry (CV). Under...

In this paper, the syntheses of twelve asymmetric curcumin analogs using Pabon's method are reported. Generally, previously reported yields curcuminoids, such as 9a (53%), 9c (38%), and 9k have been moderate or low. Herein, we propose that low were due to presence water n-BuNH2 in reaction media. To prove formulated hypothesis, demonstrated can be improved by adding molecular sieves (MS) (4 Å) mixture, thus reducing interference water. Therefore, (41-76%) obtained, except for 9b (36.7%), 9g...

Nanomaterials filled polymers system is a simple method to produce organic/inorganic hybrid with synergistic or complementary effects. The properties of nanocomposites strongly depend on the dispersion effects nanomaterials in polymer and their interfaces. optimized interface would decrease barrier height between filler for charge transfer. To avoid aggregation metal nanoparticles improve interfacial transfer, Pt nanodots non-conjugated was synthesized an situ method. results exhibited that...

Background To evaluate the systematic mediastinal lymph node (LN) dissection outcomes and conversion rates of uniportal video‐assisted thoracoscopic surgery (UVATS). Methods Patients with non‐small‐cell lung cancer who underwent (VATS) LN between January 2015 2017 were retrospectively reviewed. We categorized patients into two groups according to different surgical approaches. Patients' clinical data collected compared. The index estimated benefit from was used therapeutic value for each...

Abstract Background The design and synthesis of hybrid molecules will explore finding new drugs. Objectives synthesized to evaluate their biological properties. Methods Apply click chemistry tether flavonols benzenesulfonamide. Results Two drug candidates show potential against lung cancer. Conclusions did not affect the normal cells provided a route.

Recently, the detectable rate of ground-glass opacity (GGO ) was significantly increased, a appropriate diagnosis before clinic treatment tends to be important for patients with GGO lesions. The aim this study is validate ability mean computed tomography (m-CT) value predict tumor invasiveness, and compared other measurements such as Max CT value, size, solid size C/T ratio (consolid/tumor ratio, C/T) find out best measurement invasiveness.A retrospective conducted 129 who recieved lobectomy...

Polyaniline/Au nanocomposites were synthesized by a novel method. Aniline monomers loaded in the hydrophobic cavities of beta-cyclodextrin, and polymerization reaction occurred at interface beta-cyclodextrin liquid phase chloroauric acid. UV-vis absorbance indicated that nanocomposite covered range visible light NIR (near infrared). The photo-excitation experiment was carried out with typical wavelengths (405 nm, 532 650 nm) (780 808 980 1064 regions (10–200 mW) based on Au inter-digital...

In this paper, the seeds and rinds of passion fruit, which are agricultural waste juice processing, were recycled to investigate their biological activities for sustainable use. De-oiled seed powders (S) successively extracted by refluxing 95% ethanol (95E), 50E, hot water (HW), respectively, obtain S-95EE, S-50EE, S-HWE. Dried rind HW 95E rind-HWE rind-95EE, respectively. S-50EE S-95EE showed most potent extracts, such as anti-amyloid-β1-42 aggregations anti-acetylcholinesterase inhibitors,...

Conductive hearing loss simulations have attempted to estimate the speech-understanding difficulties of children with otitis media effusion (OME). However, validity this approach has not been evaluated. The research aim present study was investigate whether a simple, frequency-specific, attenuation-based simulation OME-related able reflect actual effects conductive on speech perception.Forty-one school-age were recruited. Each child OME matched same sex and age counterpart normal make...

Abstract We synthesized multiple cinnamils and quinoxalines to evaluate their anticancer activity. Cinnamils were used as precursors for via condensation with 1,2‐diaminobenzene. Among the 26 compounds reported in this article, we found that cinnamil 3l exhibited its inhibitory effect an IC 50 value of 1.45 ± 0.98 μM, significantly higher than doxorubicin (8.5 0.85 μM) against pancreatic cancer cells (PANC‐1). Additionally, (IC 10.98 3.63 showed less cytotoxicity Hs68 (0.92 1.11 μM). The...

Through the comparative analysis of acute and chronic pain postoperative between single port triple video-assisted thoracic surgery to seek better method which can reduce incidence in patients with lung cancer.Data 232 who underwent -VATS (n=131) or VATS (n=101) for non-small cell cancer (NSCLC) on January 1, 2016 June 30, 2017 our hospital were analyzed. The clinical operative data assessed, numeric rating scale (NRS) was used evaluate mean score 1th, 2th, 3th, 7th, 14th days, 3th months...