A5069340107- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Adrenal Hormones and Disorders
- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- ECG Monitoring and Analysis
- Dysphagia Assessment and Management
- Gastric Cancer Management and Outcomes
- Respiratory and Cough-Related Research
- Voice and Speech Disorders
- Ion Transport and Channel Regulation
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Traditional Chinese Medicine Analysis
- Peripheral Artery Disease Management
- Paraoxonase enzyme and polymorphisms
- Aquaculture disease management and microbiota
- Liver physiology and pathology
- Facial Nerve Paralysis Treatment and Research
National Taiwan University Hospital
2017-2025
National Yunlin University of Science and Technology
2021-2025
Ningbo Medical Center Lihuili Hospital
2025
Ningbo University
2025
National Taiwan University
2022-2024
University of Science and Technology of China
2023-2024
Wannan Medical College
2023-2024
Affiliated Hospital of Hangzhou Normal University
2023
Zhejiang Chinese Medical University
2023
Lishui City People's Hospital
2022
Abstract Primary aldosteronism (PA) is the most common secondary hypertension. The best treatment for a lateralized PA unilateral adrenalectomy. Recent studies explored partial adrenalectomy (pAdx) to reduce risk of adrenal insufficiency. However, in cases involving multiple aldosterone-producing micronodules/nodules (mAPM/mAPN), pAdx cannot completely remove all origins excess aldosterone and might not resolve CYP11B2 immunohistochemical staining helps HISTALDO (Histopathology PA)...
(1) Background: The role of using artificial intelligence (AI) with electrocardiograms (ECGs) for the diagnosis significant coronary artery disease (CAD) is unknown. We first tested hypothesis that AI to read ECG could identify CAD and determine which vessel was obstructed. (2) Methods: collected data from a multi-center retrospective cohort patients documented by invasive angiography control in Taiwan 1 January 2018 31 December 2020. (3) Results: trained convolutional neural networks (CNN)...
Abstract Context The captopril challenge test (CCT) is a commonly used confirmation that identifies the magnitude of renin- and angiotensin II-independent aldosterone production, thus presence severity primary aldosteronism (PA). Objective This study investigated association between post-CCT plasma concentration (PAC) cardiovascular remodeling diastolic dysfunction. Methods A total 540 PA patients with complete CCT echocardiographic data were retrospectively analyzed. Clinical parameters...
Mild autonomous cortisol secretion (MACS) is common in adrenal adenomas, including patients with primary aldosteronism (PA) aldosterone-producing adenomas (APA). This study investigated the impact of MACS on cardiac remodeling and diastolic dysfunction APA. We prospectively enrolled 483 was defined as a level >1.8 μg/dL after an overnight dexamethasone suppression test (DST). Clinical, biochemical, echocardiographic data were collected at baseline one-year following targeted treatments. In...
BACKGROUND Gastric cancer is among the most prevalent malignancies worldwide. Despite significant advancements in chemoradiotherapy, targeted therapy, and neoadjuvant conventional surgical intervention remains cornerstone of gastric management. Improvements techniques, coupled with use staplers other advanced instruments, have substantially reduced incidence complications mortality following surgery. However, dysphagia a common postoperative complication. AIM To retrospectively investigate...
Primary aldosteronism is associated with a higher incidence of left ventricular (LV) hypertrophy and diastolic dysfunction than essential hypertension. However, systolic function via endocardial measurements similar between patients primary Speckle-tracking echocardiography sensitive tool which can detect subclinical impairments in function. The aim this study was to investigate aldosterone-induced function.We prospectively enrolled hypertension analyzed their clinical data, biochemical...
Primary aldosteronism (PA) is hemodynamically independently associated with arterial wall stiffness as assessed by pulse wave velocity (PWV) compared essential hypertension. Arterial reflection parameters derived from analysis, such forward and backward amplitudes (Pf Pb), are promising vascular markers to predict cardiovascular outcomes in addition PWV. These have never been studied patients PA before. In study part A, we prospectively enrolled 67 132 B, another 54 were enrolled....
Abstract Objective The presence of autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) is common and potentially associated poor outcomes. aim this study was to investigate the association between ACS vascular remodeling PA patients. Design methods We prospectively enrolled 436 from October 2006 November 2019. (defined as a level >1.8 μg/dL after 1 mg dexamethasone suppression test) detected 23% Propensity score matching (PSM) age, sex, systolic diastolic...
Background Primary aldosteronism is the most common cause of secondary hypertension and associated with left ventricular hypertrophy. However, whether aldosterone excess responsible for (LV) diastolic dysfunction unknown. Methods Results We prospectively enrolled 129 patients aldosterone-producing adenoma 120 essential hypertension, analyzed their clinical, biochemical, echocardiographic data, including tissue Doppler images. The were reevaluated 1 year after adrenalectomy. After propensity...
Primary aldosteronism is the most common secondary endocrine form of hypertension and causes many cardiovascular injuries. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma. However, their impacts on left ventricular remodeling precluding interference age, sex, blood pressure are still uncertain. We enrolled 184 adenoma patients who received adrenalectomy. Clinical, biochemical, echocardiographic data were analyzed preoperatively 1 year postoperatively....
Ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF/MS) was developed to identify the absorbed parent components and metabolites in rat bile, plasma urine after oral administration of Radix Paeoniae Alba extract (RPAE). A total 65 compounds were detected samples, including 11 54 metabolites. The results indicated that glucuronidation, hydroxylation methylation major metabolic pathways RPAE. Furthermore, this work demonstrated...
To quantitatively assess the pulmonary vasculature using non-contrast computed tomography (CT) in patients with chronic thromboembolic hypertension (CTEPH) pre- and post-treatment correlate CT-based parameters right heart catheterization (RHC) hemodynamic clinical parameters.A total of 30 CTEPH (mean age, 57.9 years; 53% female) who received multimodal treatment, including riociguat for ≥ 16 weeks or without balloon angioplasty underwent both CT analysis RHC were included. The radiographic...
Acupuncture has achieved good results in the treatment of cough, asthma, chronic obstructive pulmonary disease (COPD) and other lung diseases, but mechanism associated with acupuncture cough induced by surgery is unknown. We investigated whether therapy could improve symptoms after through cyclic-AMp dependent protein kinase A (PKA)/cyclic-AMp C (PKC) regulation transient receptor potential vanilloid-1 (TRPV1) signaling pathway.The guinea pigs were divided into 5 groups: Sham operation Group...
Background Primary aldosteronism (PA) is associated with higher atrial fibrillation prevalence and other cardiovascular complications. However, the effect of target treatment to prevent new-onset (NOAF) remains unclear. This study investigated incidence NOAF under different strategies in patients PA. Methods Results We analyzed longitudinal data for PA without history from 1997 2009 within National Health Insurance Research Database Taiwan. Patients essential hypertension matched by...