A5078038719- Effects and risks of endocrine disrupting chemicals
- Hormonal Regulation and Hypertension
- Vitamin D Research Studies
- Heavy Metal Exposure and Toxicity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Per- and polyfluoroalkyl substances research
- Pulmonary Hypertension Research and Treatments
- Adrenal and Paraganglionic Tumors
- Antioxidant Activity and Oxidative Stress
- Trace Elements in Health
- GDF15 and Related Biomarkers
- Blood Pressure and Hypertension Studies
- Heavy Metals in Plants
- Adipokines, Inflammation, and Metabolic Diseases
- Eicosanoids and Hypertension Pharmacology
- Atherosclerosis and Cardiovascular Diseases
- Birth, Development, and Health
- Vascular Anomalies and Treatments
- Heart Rate Variability and Autonomic Control
- Sodium Intake and Health
- Cardiovascular and exercise physiology
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Dye analysis and toxicity
- Body Composition Measurement Techniques
National Taiwan University Hospital
2016-2024
National Yunlin University of Science and Technology
2021-2024
National Taiwan University
2023
China Medical University
2022
An excess of aldosterone results in cardiac remodelling and fibrosis. Interleukin-6 (IL-6) is a key mediator the fibrotic process; however, effect on expression IL-6 remains unclear. We investigated whether induces thereby contributes to process. In this clinical study, we prospectively enrolled 25 patients with primary aldosteronism (PA) 26 essential hypertension (EH). The PA had higher plasma levels, left ventricular mass index, degree myocardial fibrosis, more impaired diastolic function...
Primary aldosteronism is associated with a higher incidence of left ventricular (LV) hypertrophy and diastolic dysfunction than essential hypertension. However, systolic function via endocardial measurements similar between patients primary Speckle-tracking echocardiography sensitive tool which can detect subclinical impairments in function. The aim this study was to investigate aldosterone-induced function.We prospectively enrolled hypertension analyzed their clinical data, biochemical...
Background Primary aldosteronism is the most common cause of secondary hypertension and associated with left ventricular hypertrophy. However, whether aldosterone excess responsible for (LV) diastolic dysfunction unknown. Methods Results We prospectively enrolled 129 patients aldosterone-producing adenoma 120 essential hypertension, analyzed their clinical, biochemical, echocardiographic data, including tissue Doppler images. The were reevaluated 1 year after adrenalectomy. After propensity...
Exposure to lead and cadmium has been linked changes in lipid metabolism the development of arteriosclerosis, but role lipoprotein profiles this relationship is not well understood, including potential novel biomarkers.In study, we enrolled 736 young Taiwanese subjects aged 12 30 years assess correlation between urine levels cadmium, profiles, carotid intima-media thickness (CIMT).Higher were significantly associated with higher low-density cholesterol (LDL-C), small dense LDL-C (sdLDL-C),...
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals used in the manufacture many everyday products. Previous reports have shown PFAS exposure may contribute to cardiovascular diseases (CVD). Recent studies also identified critical role for DNA methylation, model epigenetic regulation, pathogenesis CVD. Additionally, has been affect methylation. Our previous study reported positive association between serum perfluorooctane sulfonate (PFOS) levels mean...
Phthalate exposure is associated with cardiovascular risk. Among the various phthalates, di-(2-ethylhexyl) phthalate (DEHP) a deleterious plasticizer in our daily lives. This study investigated association between DEHP and alteration of heart rate variability (HRV). During 2017-2019, we recruited 974 young adults to investigate effects living environments dietary habits on cardiometabolic disorders Taiwan. We quantitatively analyzed urinary metabolites DHEP. A continuous electrocardiogram...
Aim: This study aimed to investigate the association between vitamin D deficiency and novel biomarkers of atherogenic dyslipidemia among young adults.
As one of the most common alkylphenols, 4-tertiary-octylphenol (4-tOP) is commonly used in many consumer products. Our previous epidemiological study revealed a negative correlation between serum 4-tOP levels and carotid intima-media thickness (CIMT), which serves as biomarker arteriosclerosis. We aimed to explore role apoptotic microparticles, markers vascular endothelial cell function, CIMT connection. To investigate this, we enrolled 886 Taiwanese adolescents young adults (aged 12-30...
// Chi-Sheng Hung 1 , Xue-Ming Wu 2 Ching-Way Chen 3 Ying-Hsien Vin-Cent Che-Wei Liao 4 Yi-Yao Chang 5 Ruh-Fang Yen 6 Ching-Chu Lu Mao-Yuan M. Su 7 Kao-Lang Liu Chin-Chen Li-Yu Daisy 8 Kwan-Dun Yen-Hung Lin and the TAIPAI Study Group Department of Internal Medicine, National Taiwan University Hospital College Taipei, Taoyuan General Hospital, Taoyuan, Yun-Lin Branch, Yun-Lin, Hsin-Chu Hsin-Chu, Cardiology Division Cardiovascular Medical Center, Far Eastern Memorial New Taipei City, Nuclear...
Abstract Background Adiponectin is a key protein produced in adipose tissue, with crucial involvement multiple metabolic processes. Di-(2-ethylhexyl) phthalate (DEHP), one of the compounds used as plasticizer, has been shown to decrease adiponectin levels vitro and vivo studies. However, role angiotensin I-converting enzyme (ACE) gene polymorphism epigenetic changes relationship between DEHP exposure not well understood. Methods This study examined correlation urine metabolite, marker...
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease, caused by obstruction and incomplete resolution of thrombus further remodeling the artery. The treatment CTEPH depends on location its surgical accessibility.1 In operable CTEPH, endarterectomy (PEA) remains choice.1 authors’ experience, PEA may be conducted safely with relatively low risk, patients who undergo successful have significant improvement in their clinical status hemodynamic data.2 However, inoperable...
Abstract Background Adiponectin is a key protein produced in adipose tissue, with crucial involvement multiple metabolic processes. Di-(2-ethylhexyl) phthalate (DEHP), one of the compounds used as plasticizer, has been shown to decrease adiponectin levels vitro and vivo studies. However, role angiotensin I-converting enzyme (ACE) gene polymorphism epigenetic changes relationship between DEHP exposure not well understood. Methods This study examined correlation urine metabolite, marker...
Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals used to make many daily-use products. Previous studies have shown that PFAS exposure may be linked cardiovascular diseases (CVD) their risk factors. Recent also identified critical role for epigenetics, including DNA methylation, in the pathogenesis CVD. Additionally, has been affect methylation. Our previous study reported serum perfluorooctane sulfonate (PFOS) levels were positively associated with mean carotid...
As one of the most common alkylphenols, 4-tertiary-octylphenol (4-tOP) is an intermediate product for manufacture epoxy resins and polycarbonates. Our previous epidemiological report showed a negative association between serum 4-tOP concentrations carotid intima-media thickness (CIMT), biomarker arteriosclerosis. However, role apoptotic microparticles, markers vascular endothelial cell function, in CIMT has never been investigated. We included 886 Taiwanese adolescents young adults (12–30...
Abstract BackgroundPhthalate exposure is associated with cardiovascular risk. Among the various phthalates, di-(2-ethylhexyl) phthalate (DEHP) most important plasticizer in our daily lives. This study investigated association between DEHP and alteration of heart rate variability (HRV).MethodsDuring 2017-2019, we recruited 974 young adults to investigate effects living environments dietary habits on cardiometabolic disorders Taiwan. We quantitatively analyzed urinary metabolites including...