A5000663844- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Blood Pressure and Hypertension Studies
- Pituitary Gland Disorders and Treatments
- Biliary and Gastrointestinal Fistulas
- Pediatric Urology and Nephrology Studies
- Gastrointestinal disorders and treatments
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Eicosanoids and Hypertension Pharmacology
- Antenna Design and Analysis
- Ureteral procedures and complications
- Cardiac Structural Anomalies and Repair
- Pancreatitis Pathology and Treatment
- Kidney Stones and Urolithiasis Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Electrolyte and hormonal disorders
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Growth Hormone and Insulin-like Growth Factors
- Liver Disease Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Thyroid Cancer Diagnosis and Treatment
National Taiwan University Hospital
2016-2025
National Taiwan University
2010-2025
National Kaohsiung University of Science and Technology
2021-2024
Fox Chase Cancer Center
2023-2024
Taipei Medical University
2023
Taipei Medical University Hospital
2023
Taipei Tzu Chi Hospital
2021
GTx (United States)
2021
National Yang Ming Chiao Tung University
1996-2020
University of Florida
2018
We sought to measure the clinical benefits of adrenal venous sampling (AVS), a test recommended by guidelines for primary aldosteronism (PA) patients seeking surgical cure, in large registry PA submitted AVS. Data 1625 consecutive AVS 19 tertiary referral centers located Asia, Australia, Europe, and North America were collected multicenter international registry. The end points rate bilateral success, ascertained lateralization PA, adrenalectomy, cured arterial hypertension among AVS-guided...
Even though the increasing clinical recognition of primary aldosteronism (PA) as a public health issue, its heightened risk profiles and availability targeted surgical/medical treatment being more understood, consensus in diagnosis management based on medical evidence, while recognizing constraints our real-world practice Taiwan, has not been reached.The Taiwan Society Aldosteronism (TSA) Task Force acknowledges above-mentioned issues reached this PA at inaugural meeting, order to provide...
Aims The aim of this study was to evaluate the accuracy implant placement when using robotic assistance during total hip arthroplasty (THA). Patients and Methods A 20 patients underwent a planned THA preoperative CT scans robotic-assisted software. There were nine men 11 women (n = hips) with mean age 60.8 years (sd 6.0). Pelvic femoral bone models constructed by segmenting both postoperative scan images. anatomical landmarks system matched 3D reconstructions pelvis. Acetabular component...
Adrenal venous sampling (AVS) is the key test for subtyping primary aldosteronism (PA), but its interpretation varies widely across referral centers and this can adversely affect management of PA patients.To investigate in a real-life study rate bilateral success identification unilateral their impact on blood pressure outcomes subtyped by AVS.In retrospective analysis largest international registry individual AVS data (AVIS-2 study), we investigated how different cut-off values selectivity...
Abstract Primary aldosteronism (PA) is the most common secondary hypertension. The best treatment for a lateralized PA unilateral adrenalectomy. Recent studies explored partial adrenalectomy (pAdx) to reduce risk of adrenal insufficiency. However, in cases involving multiple aldosterone-producing micronodules/nodules (mAPM/mAPN), pAdx cannot completely remove all origins excess aldosterone and might not resolve CYP11B2 immunohistochemical staining helps HISTALDO (Histopathology PA)...
Abstract Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation calcium channels been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (66 males; aged 56.3 ± 12.3years) who received adrenalectomy were collected from Taiwan investigator (TAIPAI) group. A high rate somatic mutation APA was found (n = 91, 61.5%); including...
Current guidelines and consensus documents recommend withdrawal of mineralocorticoid receptor antagonists (MRAs) before primary aldosteronism (PA) subtyping by adrenal vein sampling (AVS), but this practice can cause severe hypokalemia uncontrolled high blood pressure. Our aim was to investigate if unilateral PA be identified AVS during MRA treatment.
To investigate the feasibility of and correlation between arterial spin-labeling (ASL) dynamic contrast material-enhanced (DCE) 3-T magnetic resonance (MR) imaging in measurement renal blood flow (RBF).The review board approved this study. Nineteen healthy volunteers (seven women, 12 men; age range, 25-68 years) were recruited, each provided written informed consent. MR was performed with a whole-body system. Each subject underwent back-to-back ASL DCE imaging. Ten runs by using...
Long-term outcomes (especially mortality and/or major cardiovascular events (MACE)) of the unilateral primary aldosteronism (uPA) patients who underwent medical or surgery-targeted treatment, relative to those with essential hypertension (EH), have been scarcely reported.Using prospectively designed observational Taiwan Primary Aldosteronism Investigation cohort, we identified 858 uPA cases among 1220 and another 1210 EH controls.Operated were grouped via their 1-year post-therapy...
Abstract Context The captopril challenge test (CCT) is a commonly used confirmation that identifies the magnitude of renin- and angiotensin II-independent aldosterone production, thus presence severity primary aldosteronism (PA). Objective This study investigated association between post-CCT plasma concentration (PAC) cardiovascular remodeling diastolic dysfunction. Methods A total 540 PA patients with complete CCT echocardiographic data were retrospectively analyzed. Clinical parameters...
Abstract Context The association between KCNJ5 somatic mutations and long-term outcomes in patients with operated unilateral primary aldosteronism (uPA) is unclear. Objective To evaluate associations among mutations, clinical characteristics, incident cardiovascular events, all-cause mortality uPA after adrenalectomy a large longitudinal population study. Methods We enrolled from the Taiwan Primary Aldosteronism Investigation database who had undergone 2013 2017 followed them until 2020....
Mild autonomous cortisol secretion (MACS) is common in adrenal adenomas, including patients with primary aldosteronism (PA) aldosterone-producing adenomas (APA). This study investigated the impact of MACS on cardiac remodeling and diastolic dysfunction APA. We prospectively enrolled 483 was defined as a level >1.8 μg/dL after an overnight dexamethasone suppression test (DST). Clinical, biochemical, echocardiographic data were collected at baseline one-year following targeted treatments. In...
Objective: Congenital long QT syndrome (LQTS) with in utero onset of the rhythm disturbances is associated a poor prognosis. In this study we investigated newborn patient fetal bradycardia, 2:1 atrioventricular block and ventricular tachycardia soon after birth.
About one in four adults suffer from prehypertension. People with prehypertension are at risk of developing hypertension, being a biomarker for cardiovascular disease risk. The use milk-derived protein hydrolysates containing peptides angiotensin-converting enzyme (ACE) inhibiting properties may reduce blood pressure (BP) and thus the hypertension.We investigated BP-lowering effect casein-derived hydrolysate (C12 Peptide) during 4-week intervention period prehypertensive subjects. After...
Current data on primary aldosteronism (PA) from Asian populations are scarce. This cohort study clarifies the attributes of patients with PA in a typical Chinese population.An observational study.The records referred to Hypertension Clinic multi-centre registration Taiwan January 1995 December 2007 were reviewed. All classified into two subtypes: aldosterone-producing adenomas (APA) and idiopathic hyperaldosteronism (IHA); their characteristics compared.Our consisted 346 PA, 255 APA 91 IHA....
Background Targeted treatment with mineralocorticoid receptor antagonists (MRAs) or adrenalectomy in patients primary aldosteronism (PA) causes a decline estimated glomerular filtration rate; however, the associated simultaneous changes biomarkers of kidney tubule health still remain unclear. Methods and Results We matched 104 newly diagnosed unilateral PA who underwent were treated MRAs, bilateral essential hypertension served as controls. Functional measured before targeted 1 year after...
Primary aldosteronism (PA) is hemodynamically independently associated with arterial wall stiffness as assessed by pulse wave velocity (PWV) compared essential hypertension. Arterial reflection parameters derived from analysis, such forward and backward amplitudes (Pf Pb), are promising vascular markers to predict cardiovascular outcomes in addition PWV. These have never been studied patients PA before. In study part A, we prospectively enrolled 67 132 B, another 54 were enrolled....