A5069377916- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Hormonal Regulation and Hypertension
- Cardiomyopathy and Myosin Studies
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Effects of Exercise
- Dialysis and Renal Disease Management
- Cardiac Valve Diseases and Treatments
- Renin-Angiotensin System Studies
- Peripheral Artery Disease Management
- Heart Rate Variability and Autonomic Control
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Acute Myocardial Infarction Research
- ECG Monitoring and Analysis
National Taiwan University Hospital
2016-2025
National Taiwan University
2010-2024
Second Xiangya Hospital of Central South University
2023
Central South University
2023
National Yang Ming Chiao Tung University
2021
Cardiovascular Institute of the South
2019
Stanford University
2019
Chia-Yi Christian Hospital
2015
Institute of Clinical Research
2013
Molina Center for Energy and the Environment
2013
Objective: The inflammatory process is associated with cardiac diastolic dysfunction, which has been demonstrated to be an independent prognostic marker for the mortality of critically ill patients. We investigated association among cytokines (tumor necrosis factor-α and interleukin-6), heart failure, possible molecular mechanism. Design: Prospective case-controlled cohort studies. Setting: University hospital research laboratory. Subjects: Patients a diagnosis failure by echocardiography...
Abstract Heart failure with preserved ejection fraction (HFPEF) is characterized by myocardial interstitial fibrosis. A total of 146 patients HFPEF, were recruited. HFPEF severity was determined using Doppler imaging (E/Em) and also cardiac magnetic resonance (CMRI). Canine modeling induced aortic banding. Hemodynamic echocardiographic data obtained before after pressure loading Galectin-3 determined. Mechanical stretch cultured cardiomyocytes served as the cellular model HFPEF. Patients...
Background Atrial fibrillation (AF) is associated with increasing risk of thromboembolic or ischemic stroke. The CHA2DS2-VASc score a well-established predictor AF Patients have an increased stroke if they diabetes. Use sodium-glucose cotransporter-2 inhibitor (SGLT2i) has been shown to be favorable cardiovascular outcomes in patients It was unknown whether use SGLT2i decreased who Methods and Results A total 9116 diabetes from the National Taiwan University historical cohort were...
Objectives The aim of the study was to investigate association between angiotensin II type 1 receptor (AGTR1) gene polymorphisms and diastolic heart failure (DHF) in a case controlled study. Methods Of 1752 consecutive patients analyzed, 176 diagnosed with DHF confirmed by echocardiography were recruited. Controls matched one-to-one age, sex, hypertension, diabetes, renal function, medication use. We genotyped 11 single nucleotide (SNPs) according HapMap Han Chinese Beijing databank across...
We investigated the molecular mechanism of rapid-depolarization-induced atrial fibrosis.We used a direct myocyte-fibroblast contact co-culture and fibroblast-specific transforming growth factor β1 (TGF-β1), connective tissue (CTGF) procollagen type I α-1 (COL1A1) luciferase reporter system to investigate possible fibrosis. Mouse fibroblasts were first transfected with promoter-luciferase reporters, then co-cultured HL-1 myocytes. Rapid depolarization myocytes by rapid electrical field...
AimsTNF-alpha (TNF-α) causes left ventricular diastolic dysfunction. Down-regulation of sarcoplasmic reticulum Ca2+-ATPase 2a protein (SERCA2a) expression is one the major mechanisms underlying We investigated whether TNF-α modulates SERCA2a and alters cardiac function, its detailed signalling pathway.
Abstract Background Symptoms of heart failure with preserved left ventricular systolic function are common among patients undergoing peritoneal dialysis (PD). Epicardial fat (EpF) is an ectopic depot possible paracrine or mechanical effects on myocardial function. The aim our current study to assess the association between EpF and Left diastolic dysfunction (LVDD) in PD clarify relationships EpF, inflammation, LVDD this population. Methods This was a cross-sectional 149 who were PD....
Patients with severe kidney function impairment often have autonomic dysfunction, which could be evaluated noninvasively by heart rate variability (HRV) analysis. Nonlinear HRV parameters such as detrended fluctuation analysis (DFA) has been demonstrated to an important outcome predictor in patients cardiovascular diseases. Whether cardiac dysfunction measured DFA is also a useful prognostic factor end-stage renal disease (ESRD) receiving peritoneal dialysis (PD) remains unclear. The purpose...
Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Previous genome-wide association studies had identified single-nucleotide polymorphisms in several genomic regions to be associated with AF. In human genome, copy number variations (CNVs) are known contribute disease susceptibility. Using a multistage approach identify AF susceptibility CNVs, we here show 4,470-bp diallelic CNV first intron of potassium interacting channel 1 gene ( KCNIP1) strongly Taiwanese...
The objective of this study was to examine the association between use statins and risk newly diagnosed dementia in an elderly population.Random samples 1,000,000 individuals covered by National Health Insurance Taiwan were included analysis. All participants 65 years or older without either did not start treatment with from 1 August 1997 31 December 2010. Patients established before excluded. Baseline characteristics matched (by propensity score) those who receive statins.A total 57,669...
Type A aortic dissection manifesting as acute myocardial infarction (AMI) is relatively rare but could be catastrophic if the management not appropriate. This study investigated incidence, outcome and potential diagnostic pitfalls of patients with such manifestations, proposes a useful paradigm.From 1 January 1995 to 31 July 2006, 531 admitted our hospital initial or later diagnosis were reviewed. Two hundred thirty-nine diagnosed Stanford type mortality rate 17% (41/239). Eleven (5%) 239...
The purpose of this study was to investigate the associations among central obesity, inflammation, and left ventricular (LV) diastolic dysfunction by structural equation modeling. Echocardiographic parameters were assessed in 102 otherwise‐healthy adults over age 30. participants classified as having LV echocardiographic findings including mitral inflow E/A ratio <1, deceleration time >220 cm/s, or decreased peak annular early velocity tissue Doppler imaging otherwise control group....