A5005677224- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- Lung Cancer Treatments and Mutations
- Receptor Mechanisms and Signaling
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Image and Signal Denoising Methods
- Streptococcal Infections and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Pharmaceutical Practices and Patient Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced Data Compression Techniques
- Analog and Mixed-Signal Circuit Design
- Hormonal Regulation and Hypertension
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Calpain Protease Function and Regulation
- Antimicrobial Resistance in Staphylococcus
- Cancer Treatment and Pharmacology
- Digital Filter Design and Implementation
- 3D Surveying and Cultural Heritage
Chung Shan Medical University Hospital
2012-2024
Chung Shan Medical University
2011-2023
National Taiwan University Hospital
2022
SAS Institute (United States)
2021
Chia Nan University of Pharmacy and Science
2017
Wenzao Ursuline University of Languages
2017
National Academy of Medicine
2015
Bridge University
2012
Medical University of Vienna
2010
National Kaohsiung First University of Science and Technology
2005-2009
PV Stenosis after AF Ablation. Introduction: Elimination of the initiating focus within pulmonary vein (PV) using radiofrequency (RF) catheter ablation is a new treatment modality for drug‐refractory atrial fibrillation. However, information on long‐term safety RF limited. Methods and Results: In 102 patients with fibrillation at least one from PV, series transesophageal echocardiography was performed to monitor effect PV. There were 66 foci in right upper 65 left Within 3 days ablation, 26...
Background —The prospective, randomized study comparing 4- with 8-mm tip electrodes for radiofrequency linear ablation of typical atrial flutter is not available. Methods and Results —A total 104 consecutive patients were randomly assigned to undergo using a (Group I, n=54) or electrode II, n=50) catheter (temperature-control model, preset 70°C). If complete bidirectional isthmus block could be achieved after 5 pulses, the was changed other type; maximal pulse number limited <10 pulses....
Many studies have shown that crosstalk exists between apoptosis and autophagy, despite differences in mechanisms these processes. Paeonol, a major phenolic compound isolated from Moutan Cortex Radicis, the root bark of Paeonia × suffruticosa Andrews (Paeoniaceae), is widely used traditional Chinese medicine as an antipyretic, analgesic anti-inflammatory agent. In this study, we investigated detailed molecular autophagy underlying cardioprotective effects paeonol rats subjected to myocardial...
(1) Background: The role of using artificial intelligence (AI) with electrocardiograms (ECGs) for the diagnosis significant coronary artery disease (CAD) is unknown. We first tested hypothesis that AI to read ECG could identify CAD and determine which vessel was obstructed. (2) Methods: collected data from a multi-center retrospective cohort patients documented by invasive angiography control in Taiwan 1 January 2018 31 December 2020. (3) Results: trained convolutional neural networks (CNN)...
Atrial Tachycardia. Introduction : The characteristics of atrial tachycardia (AT) have varied widely among different reports. anatomic locations ATs may bias the results. We propose that septal and free‐wall characteristics. Methods Results One hundred forty‐one patients with AT underwent electropharmacologic study, endocardial mapping, radiofrequency ablation. Forty‐nine (34.7%) had originating from anteroseptal, mid‐septal, posteroseptal areas. Tachycardia cycle length was similar between...
Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Previous genome-wide association studies had identified single-nucleotide polymorphisms in several genomic regions to be associated with AF. In human genome, copy number variations (CNVs) are known contribute disease susceptibility. Using a multistage approach identify AF susceptibility CNVs, we here show 4,470-bp diallelic CNV first intron of potassium interacting channel 1 gene ( KCNIP1) strongly Taiwanese...
Introduction: High recurrence rate is still a major problem associated with ablation of paroxysmal atrial fibrillation (AF). Most the recurrences occur within 6 months after ablation. The characteristics very late recurrent AF (>12 ablation) have not been reported. Methods and Results: Two hundred seven patients drug‐refractory underwent successful focal or isolation foci. After first procedure, Holter monitoring event recorders were used to evaluate symptomatic AF. A second procedure was...
BACKGROUND The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score has been verified as a useful diagnostic tool detecting necrotizing fasciitis (NF). Its application, however, is mainly NF types I and II. practical relevance of the LRINEC Vibro vulnificus–related skin soft tissue infection (SSTI) was hardly ever investigated. aim this study to assess applicability scoring system identify NF-predicting factors in patients with V. vulnificus–caused SSTI. METHODS A retrospective...
By promoting atrial structural remodeling, hypoxia contributes to the development of fibrillation substrate. Our study aimed investigate modulatory effect on profibrotic activity in cultured HL-1 cardiomyocytes and explore possible signaling transduction mechanisms vitro. Hypoxia (1% O2) significantly time-dependently increased expression hypoxia-inducible factor (HIF)-1α fibrotic marker proteins collagen I III (COL1A COL3A), transforming growth (TGF)-β1 α-smooth muscle actin (SMA). Western...
Fibrosis is a hallmark of atrial structural remodeling. The main aim this study was to investigate the role micro-ribonucleic acids (miRNAs) in modulation fibrotic molecular mechanisms response hypoxic conditions, which may mediate fibrosis. Under condition hypoxia induced by chamber, miRNA arrays were used identify specific miRNAs associated with genes. Luciferase assay, real-time polymerase chain reaction, immunofluorescence and Western blotting effects on expressions markers collagen I...
Early restoration of sinus rhythm following ablation atrial fibrillation (AF) facilitates reverse remodeling and improves the long-term outcome. The purpose this study was to determine predictors outcome in patients with very early AF recurrences (< 2 days).Ablation performed 339 consecutive (paroxysmal = 262). Biatrial voltage mapped during rhythm. If recurrent occurred within days ablation, electrical cardioversion restore Very 39 (15%) paroxysmal 26 (34%) nonparoxysmal AF. Patients...
Ischemic stroke is characterized by the loss of cerebral blood flow, which frequently leads to neurological deficits. Tissue plasminogen activator only therapeutic agent approved treat ischemic but increases risk intracranial hemorrhage and mortality. The fibrinogen-depleting lumbrokinase has been used improve myocardial perfusion in symptomatic stable angina prevent secondary stroke. Lumbrokinase highly fibrin-specific active presence fibrin. Therefore, a low due excessive fibrinolysis. In...
The effect of beta-endorphin on plasma glucose levels was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). A dose-dependent lowering observed the fasting STZ-diabetic rat fifteen minutes after intravenous injection beta-endorphin. glucose-lowering abolished by pretreatment with naloxone or naloxonazine at doses sufficient to block opioid mu-receptors. Also, unlike wild-type mice, failed induce its mu-receptor knock-out mice. In isolated soleus muscle, enhanced uptake...
Abstract Ventricular arrhythmias commonly originate from the right ventricular out‐flow tract ( RVOT ). However, electrophysiological characteristics and Ca 2+ homoeostasis of cardiomyocytes remain unclear. Whole‐cell patch clamp indo‐1 fluorometric ratio techniques were used to investigate action potentials, ionic currents in isolated rabbit apex RVA Conventional microelectrodes record electrical activity before after KN ‐93, a /calmodulin‐dependent kinase II inhibitor, or ranolazine, late...
Objectives Hydroxychloroquine (HCQ) is widely used to treat rheumatic diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS). Cardiac arrhythmia has been concerned as important safety issue for HCQ. The aim of this study was investigate whether hydroxychloroquine increases new-onset among patients with RA, SLE or SS. Methods This a retrospective cohort that conducted from the longitudinal health insurance database Taiwan. Patients newly...
Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extraction. variable region V3−V4 16S rRNA gene was sequenced using Illumina MiSeq platform. metabolite amounts analyzed Kyoto Encyclopedia Genes Genomes (KEGG) pathways. Results: bacteria more enriched in AMI group...
Purpose Atrial fibrillation (AF) is a significant independent risk factor for 1-year mortality in patients with first acute ischemic stroke (AIS). The CHA2DS2-VASc score was initially developed to assess the of AF. Recently, this scoring system has been demonstrated have clinical value predicting long-term outcomes AIS but evidence insufficient. This large-scale prospective cohort study investigated predictive such patients. Methods We included from Taiwan Stroke Registry (TSR) during...
Uterine arteriovenous malformations (AVM) are very uncommon disorders. Successful conservative treatment with subsequently conceived is rarely reported. We describe a 31-year-old woman complex and large postmolar AVM; she was successfully treated transarterial selective embolization for long history of repeated excessive vaginal bleeding anemia. She resumed normal menstrual periods soon after treatment, about 2 years later. A healthy male baby delivered at 39 weeks gestation via route....