A5070209838- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Lysosomal Storage Disorders Research
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac tumors and thrombi
- Advanced MRI Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Glycogen Storage Diseases and Myoclonus
- Cardiomyopathy and Myosin Studies
- Pericarditis and Cardiac Tamponade
- Cardiovascular Effects of Exercise
- Sarcoidosis and Beryllium Toxicity Research
- Peptidase Inhibition and Analysis
- Infective Endocarditis Diagnosis and Management
- Trypanosoma species research and implications
Taipei Veterans General Hospital
2016-2025
National Yang Ming Chiao Tung University
2016-2025
Zhejiang Chinese Medical University
2024
Putian University
2024
National Yang Ming University Hospital
2000-2021
Academia Sinica
2021
National Taipei University
2011-2020
Edith Cowan University
2018
Johns Hopkins Medicine
2010
Johns Hopkins University
2010
Background Nutritional status has been related to clinical outcomes in patients with heart failure. We assessed the association between nutritional status, indexed by prognostic index ( PNI ), and survival hospitalized for acute Methods Results A total of 1673 (age 76±13 years, 68% men) failure a tertiary medical center were analyzed. was calculated as 10×serum albumin (g/dL)+0.005×total lymphocyte count (per mm 3 ). National Death Registry linked identify all‐cause cardiovascular death....
RF Catheter Ablation for Atrial Flutter. Introduction : Little is known about the predictors of recurrent atrial flutter or fibrillation after successful radiofrequency ablation typical flutter. In addition, there only limited evidence suggesting that elimination would modify natural history in patients who experienced both these arrhythmias. The aims present study were to investigate long‐term results catheter and examine late occurrence a large population with Methods Results consisted 144...
Background —The prospective, randomized study comparing 4- with 8-mm tip electrodes for radiofrequency linear ablation of typical atrial flutter is not available. Methods and Results —A total 104 consecutive patients were randomly assigned to undergo using a (Group I, n=54) or electrode II, n=50) catheter (temperature-control model, preset 70°C). If complete bidirectional isthmus block could be achieved after 5 pulses, the was changed other type; maximal pulse number limited <10 pulses....
Background Multiple-site atrial pacing has been shown to prevent recurrence of fibrillation. However, information about the mechanisms different modes in prevention fibrillation was not clear. Methods and Results Forty-two patients without structural heart disease were classified into group 1 2 according absence or presence clinical fibrillation, respectively. Atrial conduction time electrogram width right posterior interatrial septum (RPS) measured during drive-train stimulation (S1) early...
Background Hyponatremia predicts poor prognosis in patients with acute heart failure ( AHF ). However, the association of severity hyponatremia and changes serum sodium levels long‐term outcome has not been delineated. Methods Results The study population was drawn from HARVEST registry H eart F a ilure R egistry Taipei Ve teran s General Hospi t al), so that hospitalized for AHF) composed this study. National Death Registry linked to identify clinical outcomes all‐cause mortality...
Cardiac amyloidosis is one form of systemic caused by abnormal amyloid fibrils deposited in the extracellular space myocardium causing heart failure because restrictive cardiomyopathy and conduction disturbances. The incidence prevalence cardiac are higher than previously noted, particularly among special populations. most common forms light chain transthyretin cardiomyopathy. Even though more 70% patients with have amyloidosis, diagnosis often delayed, suggesting significant gaps knowledge...
Highlights•Severe LVH is an independent predictor of MACE in Fabry disease.•Sex-specific grading LVMI by echocardiography applicable for disease.•LV GLS refines the prognosis prediction patients with severe LVH.•Grading and LV valuable risk assessment disease.AbstractBackgroundThe prognostic value different grades left ventricular hypertrophy (LVH) (LV) mechanical function disease unclear. We aimed to evaluate association between severity LVH, function, clinical outcomes disease.MethodsWe...
Background —Regional differences in recovery of tachycardia-induced changes atrial electrophysiological properties have not been well studied. Methods and Results —In the control group (5 dogs), effective refractory period (AERP) inducibility fibrillation (AF) were assessed before every 4 hours for 48 after complete atrioventricular junction (AVJ) ablation with 8-week VVI pacing. In experimental 1 (15 AERP AF AVJ rapid right (RA) pacing (780 bpm) 2 (7 left (LA) duration obtained from 7...
AHEAD (A: atrial fibrillation; H: hemoglobin; E: elderly; A: abnormal renal parameters; D: diabetes mellitus) score has been related to clinical outcomes of acute heart failure. However, the prognostic value in failure patients with either reduced or preserved left ventricular ejection fraction (HFrEF and HFpEF) remain be elucidated.The study population consisted 2143 (age 77±12 years, 68% men, 38% HFrEF) hospitalized primarily for a median follow-up 23.75 months. The performance (atrial...
This 2025 updated consensus outlines the diagnostic strategy for transthyretin amyloid cardiomyopathy (ATTR-CM). Given that ATTR-CM is a significant contributor to heart failure, this article emphasizes importance of making an early and precise diagnosis, particularly as new therapeutic options become available. Highlighting critical accurate in light emerging modalities, underscores central role
Left ventricular hypertrophy (LVH) is clinically important; current electrocardiography (ECG) diagnostic criteria are inadequate for early detection. This study aimed to develop an artificial intelligence (AI)-based algorithm improve the accuracy and prognostic value of ECG LVH A total 42 016 patients (64.3 ± 16.5 years, 55.3% male) were enrolled. LV mass index was calculated from echocardiographic measurements. screening utilized criteria, including Sokolow-Lyon, Cornell product,...
The prognostic value of central aortic pulse pressure (PP-C) may have been underestimated due to its measurement inaccuracy. We aimed investigate the accuracy noninvasive brachial cuff-based estimation PP-C by a generalized transfer function (GTF) or novel wave analysis (PWA) approach directly estimate PP-C.Invasive high-fidelity right and tracings, left volume plethysmography (PVP) waveforms from an oscillometric blood (BP) monitor were all digitized simultaneously in 40 patients during...
The late-onset type of Fabry disease (FD) with GLA IVS4 + 919G > A mutation has been shown to lead cardiovascular dysfunctions. In order eliminate variations in other aspects the genetic background, we established isogenic control induced pluripotent stem cells (iPSCs) for identification pathogenetic factors FD phenotypes through CRISPR/Cas9 genomic editing. We adopted droplet digital PCR (ddPCR) efficiently capture mutational events, thus enabling isolation corrected from FD-iPSCs. Both...
A challenge in accurately identifying and classifying left ventricular hypertrophy (LVH) is distinguishing it from hypertrophic cardiomyopathy (HCM) Fabry disease. The reliance on imaging techniques often requires the expertise of multiple specialists, including cardiologists, radiologists, geneticists. This variability interpretation classification LVH leads to inconsistent diagnoses. LVH, HCM, can be differentiated using T1 mapping cardiac magnetic resonance (MRI). However, differentiation...
Impaired renal function (IRF) prevails in patients with acute heart failure. The study aimed to investigate the prevalence of on-admission IRF and its association short-term long-term mortalities hospitalized for HF reduced (HFrEF), mildly (HFmrEF), preserved (HFpEF) left ventricular ejection fraction (LVEF).Patients failure were enrolled stratified by LVEF into three phenotypes as HFpEF (≥50%), HFmrEF (40-49%), HFrEF (<40%). was defined an estimated glomerular filtration rate ≤60...
Patients with the later-onset IVS4+919G>A (IVS4) Fabry mutation are known to have positive central nervous system involvement compared age- and sex-matched controls. This study compares manifestations in patients IVS4 or classical mutations. was a retrospective analysis of magnetic resonance imaging (MRI) data from Taiwanese enrolled Outcome Survey (sponsored by Shire; extracted March 2015). Twenty-five (19 males) 12 (four underwent MRI at median (range) age 60.7 (45.0–70.4) 43.0 (18.0–61.4)...
The excess pressure integral (XSPI), derived from analysis of the arterial curve, may be a significant predictor cardiovascular events in high-risk patients. We comprehensively investigated prognostic value XSPI for predicting long-term mortality end-stage renal disease patients undergoing regular hemodialysis.A total 267 uremic (50.2% female; mean age 54.2±14.9 years) receiving hemodialysis more than 6 months were enrolled. Cardiovascular parameters obtained by echocardiography and...
Electromechanical Interval and Paroxysmal Atrial Fibrillation. Introduction: It is difficult to discriminate patients with without paroxysmal atrial fibrillation (PAF). The electromechanical interval determined by the transthoracic echocardiogram demonstrated be a predictor of new onset AF. aim our study was investigate whether useful parameter identify PAF. Methods Results: A total 297 (PAF group = 103; control 194) mean age 59.4 ± 12.4 years were enrolled. (PA-PDI) defined as time from...