A5087501806- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Function and Risk Factors
- Sarcoidosis and Beryllium Toxicity Research
- Eosinophilic Disorders and Syndromes
- Medical Imaging and Pathology Studies
- Advanced Radiotherapy Techniques
- Blood Pressure and Hypertension Studies
- Prostate Cancer Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Parathyroid Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Radiopharmaceutical Chemistry and Applications
- Cardiovascular Disease and Adiposity
- Muscle and Compartmental Disorders
Taipei Veterans General Hospital
2016-2025
National Yang Ming Chiao Tung University
2023-2025
Cedars-Sinai Medical Center
2018-2022
Combined analysis of SPECT myocardial perfusion imaging (MPI) performed with a solid-state camera on patients in 2 positions (semiupright, supine) is routinely used to mitigate attenuation artifacts. We evaluated the prediction obstructive disease from combined semiupright and supine stress MPI by deep learning (DL) as compared standard total deficit (TPD). <b>Methods:</b> 1,160 without known coronary artery (64% male) were studied. Patients underwent <sup>99m</sup>Tc-sestamibi...
To optimize per-vessel prediction of early coronary revascularization (ECR) within 90 days after fast single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) using machine learning (ML) and introduce a method for patient-specific explanation ML results in clinical setting.A total 1980 patients with suspected artery disease (CAD) underwent stress/rest 99mTc-sestamibi/tetrofosmin MPI new-generation SPECT scanners were included. All had invasive angiography 6...
Abstract Aims Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) stress-only protocols reduce radiation exposure and cost but require clinicians to make immediate decisions regarding rest scan cancellation. We developed a machine learning (ML) approach for automatic cancellation evaluated its prognostic safety. Methods results In total, 20 414 patients from solid-state SPECT MPI international multicentre registry with clinical data follow-up major adverse...
Optimal risk stratification with machine learning (ML) from myocardial perfusion imaging (MPI) includes both clinical and data. While most variables can be derived automatically, require manual collection, which is time-consuming prone to error. We determined the fewest manually input required maintain prognostic accuracy for major adverse cardiac events (MACE) in patients undergoing a single-photon emission computed tomography (SPECT) MPI.
OBJECTIVE Prevalence and prognostic impact of cardiovascular disease differ between patients with or without diabetes. We aimed to explore differences in the prevalence prognosis myocardial ischemia by automated quantification total perfusion deficit (TPD) among RESEARCH DESIGN AND METHODS Of 20,418 individuals who underwent single-photon emission computed tomography imaging, 2,951 diabetes were matched based on risk factors using propensity score. TPD was categorized as = 0%, 0% &lt;...
Ischaemia on single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is strongly associated with cardiovascular risk. Transient ischaemic dilation (TID) and post-stress wall motion abnormalities (WMA) are non-perfusion markers of ischaemia incremental prognostic utility. Using a large, multicentre SPECT MPI registry, we assessed the degree to which these features increased risk major adverse events (MACE) in patients less than moderate ischaemia.
This 2025 updated consensus outlines the diagnostic strategy for transthyretin amyloid cardiomyopathy (ATTR-CM). Given that ATTR-CM is a significant contributor to heart failure, this article emphasizes importance of making an early and precise diagnosis, particularly as new therapeutic options become available. Highlighting critical accurate in light emerging modalities, underscores central role
Background: Phase analysis of single-photon emission computed tomography myocardial perfusion imaging provides dyssynchrony information which correlates well with assessments by echocardiography, but the independent prognostic significance is not defined. This study assessed value tomography-myocardial phase in largest multinational registry to date across all modalities. Methods: From REFINE SPECT (Registry Fast Myocardial Perfusion Imaging With Next Generation SPECT), a total 19 210...
With documented high specificity, 99m Tc-pyrophosphate (PYP) scan enables the diagnosis of transthyretin cardiomyopathy to be made reliably without endomyocardial biopsy in patients who do not have monoclonal gammopathy. We report a case with extensive myocardial uptake Perugini 3 score 3-hour Tc-PYP SPECT that suggested cardiac amyloidosis. However, followed revealed no amyloid deposition. In this case, hyperphosphatemia was most likely and presumptive cause false-positive scan. our...
Semiquantitative assessment of stress myocardial perfusion defect has been shown to have greater prognostic value for prediction major adverse cardiac events (MACE) in women compared with men single-center studies conventional single-photon emission computed tomography (SPECT) cameras. We evaluated sex-specific difference the automated quantification ischemic total (ITPD) and interaction between sex ITPD using high-efficiency SPECT cameras solid-state detectors an international multicenter...
Background: Radium-223 dichloride (Ra-223) prolongs overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) with symptomatic bone metastases. However, there is considerable variation outcomes among individuals. We aimed to evaluate the prognostic determinants associated patient following National Health Insurance (NHI) reimbursement for Ra-223 therapy Taiwan. Methods: Patients mCRPC who underwent treatment at Taipei Veterans General Hospital were retrospectively...
Waders sign is an edematous manifestation characterized by soft-tissue uptake of tracer below the midthorax and normal clearance above that level on bone scan, resembling a pair fisherman's waders. This was previous reported to be resultant from inferior vena cava obstruction. We describe portal hypertensive patient manifested as waders feature proved not having thrombotic disease. Because management thrombosis significantly different nonthrombotic cause, distinction clinically relevant. The...
Abstract Background We aimed to develop a machine learning (ML) computer score derived from stress imaging and clinical data, which indicates if the rest scan could be automatically safely canceled in routine stress/rest myocardial perfusion SPECT (MPS). Methods A total of 20414 cases REFINE registry collected 5 sites 3 countries with Tc-99m-based MPS images, follow-up were included study. All images processed at our Medical Center. The generated contours checked by experienced...