A5063824407- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
- Blood Pressure and Hypertension Studies
- ECG Monitoring and Analysis
- Cardiovascular Disease and Adiposity
- Extracellular vesicles in disease
- Coronary Interventions and Diagnostics
- Diabetes Treatment and Management
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Takotsubo Cardiomyopathy and Associated Phenomena
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Circular RNAs in diseases
- Genetic Associations and Epidemiology
- Lymphatic System and Diseases
- Inflammasome and immune disorders
- Adrenal Hormones and Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
National Taiwan University Hospital
2015-2025
National Taiwan University
2011-2025
National Yunlin University of Science and Technology
2019-2024
University of California, San Diego
2023
Genomics (United Kingdom)
2023
Atrial fibrillation (AF) and diabetes mellitus (DM) are associated with an increased risk of ischemic stroke, particularly in geriatric populations. Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have demonstrated cardiovascular benefits, but their effects on stroke may vary by age. This study aimed to explore the age-dependent SGLT2i patients AF DM. historical longitudinal follow-up cohort included 9,669 DM from National Taiwan University Hospital database (2010–2020). Patients were...
Background Atrial fibrillation (AF) is associated with increasing risk of thromboembolic or ischemic stroke. The CHA2DS2-VASc score a well-established predictor AF Patients have an increased stroke if they diabetes. Use sodium-glucose cotransporter-2 inhibitor (SGLT2i) has been shown to be favorable cardiovascular outcomes in patients It was unknown whether use SGLT2i decreased who Methods and Results A total 9116 diabetes from the National Taiwan University historical cohort were...
(1) Background: The role of using artificial intelligence (AI) with electrocardiograms (ECGs) for the diagnosis significant coronary artery disease (CAD) is unknown. We first tested hypothesis that AI to read ECG could identify CAD and determine which vessel was obstructed. (2) Methods: collected data from a multi-center retrospective cohort patients documented by invasive angiography control in Taiwan 1 January 2018 31 December 2020. (3) Results: trained convolutional neural networks (CNN)...
Genome-wide association studies (GWASs) identified common single nucleotide polymorphisms (SNPs) in more than 100 genomic regions associated with atrial fibrillation (AF). We aimed to identify novel AF genes Taiwanese population by multi-stage GWAS. In exploratory stage, we did GWAS whole genome genotypes (4,512,191 SNPs) 516 Patients from National Taiwan University registry (NTUAFR) and 5160 normal sinus rhythm controls Biobank. Significant loci were replicated 1002 independent patients...
Although advancements in the treatment of atrial fibrillation have improved patient prognosis for this persistent condition, interest development is growing. Of note fact that additional attention being focused on accompanying effect insomnia. The aim study was to investigate effects insomnia risk development.This a nationwide population-based retrospective cohort using data from Taiwan National health Insurance Research Database. We analyzed 64,421 cases and 128,842 matched controls without...
Background: Brugada syndrome (BrS) is an oligogenic arrhythmic disease with increased risk of sudden cardiac arrest. Several BrS or ECG traits-related single-nucleotide polymorphisms (SNPs) were identified through previous genome-wide association studies in white patients. We aimed to validate these SNPs patients the Taiwanese population, assessing cumulative effect alleles and BrS-polygenic score predicting events. Methods: genotyped 190 unrelated using TWB Array, Taiwan Biobank was used as...
Background: Among various bio-informative molecules transferred by exosomes between cells, micro RNAs (miRNAs), which remain remarkably stable even after freeze-and-thaw cycles, are excellent candidates for potential biomarkers coronary artery disease (CAD). Methods: Blood samples were collected from the arteries of 214 patients diagnosed with three-vessel CAD and 140 without CAD. After precipitation extraction, amounts found to decrease increased age Next-generation sequencing was performed...
Pheochromocytoma is a rare, catecholamine-secreting tumor. The classic symptoms are headache, diaphoresis, and tachycardia with paroxysmal hypertension. Other less common cardio-vascular manifestations, such as arrhythmias, angina pectoris, acute myocardial infarction, dilated cardiomyopathy, heart failure, cardiogenic shock, have occasionally been reported. Here, we report two middle-aged men myocarditis who needed an intra-aortic balloon pump extra-corporeal membrane oxygenation for life...
In patients with atrial fibrillation (AF) and end-stage renal disease (ESRD), oral anticoagulants are contraindicated, left appendage occlusion (LAAO) is an alternative treatment. However, the efficacy of thromboembolic prevention using LAAO in these has rarely been reported Asian populations. To our knowledge, this first long-term study AF undergoing dialysis Asia. study, 310 (179 men) a mean age 71.3 ± 9.6 years CHA2DS2-VASc 4.2 1.8 were consecutively enrolled at multiple centers Taiwan....
Background Implantation of the left atrial appendage occluder (LAAO) has been proven to prevent stroke effectively in patients with fibrillation who cannot tolerate anticoagulants. Incomplete endothelization LAAO may cause device‐related thrombus, and currently no good image modality exists clearly see endothelialization. We aimed use coronary optic coherence tomography (OCT) visualize Methods Results enrolled 14 (72.8±9.4 years old) undergoing pulmonary vein isolation a preexisting...
Atrial fibrillation (AF) has been linked to increased hyperthyroidism risk, but contributing factors are unclear.We aimed investigate whether AF could predict and related risk factors.This retrospective cohort study was conducted in a tertiary medical institution included patients aged 18 years or older with without at diagnosis. The endpoint defined as newly diagnosed during the follow-up period.The 8552 participants. Patients who developed new were younger proportion of females higher....
In patients with non-valvular atrial fibrillation (NVAF), the left appendage occluder (LAAO) is an alternative treatment for stroke prevention. However, long-term outcomes in Asia was generally unknown. This a retrospective longitudinal study and total of 124 contraindications to oral anticoagulants or despite under had been enrolled since 2013. Primary efficacy defined as any type stroke/systemic embolization adverse event procedure anti-thrombotic related complications. Twelve were...
Ventricular premature complex (VPC) is a common arrhythmia in clinical practice. VPC could trigger ventricular tachycardia/fibrillation or VPC-induced cardiomyopathy susceptible patients. Existing screening methods require prolonged monitoring and are limited by cost low yield when the frequency of low. Twelve-lead electrocardiogram (ECG) widely used. We aimed to identify patients with during normal sinus rhythm (NSR) using artificial intelligence (AI) machine learning-based ECG reading.We...
Background: Left atrial (LA) size represents fibrillation (AF) burden and has been shown to be a predictor for AF stroke. The CHA 2 DS -VASc score is also well-established of It unknown cardiologists whether these two risk scores are correlated, both independent prognostic predictors complimentary each other, or one them major determinant stroke patients. Method: A total 708 patients from the National Taiwan University Atrial Fibrillation Registry were longitudinally followed up more than 15...
Background Patients with drug-refractory atrial fibrillation (AF) and pre-existing left appendage occluder (LAAO) device may need pulmonary vein isolation (PVI). In this pioneer study, we investigated the impact of LAAO on AF substrates outcomes PVI. Methods From our registry, 65 patients (72.1±11.4 years old; CHA 2 DS -VASc score 3.7±2.1) were included for A balanced control group 124 without receiving PVI (70.9±10.2 old, 3.6±1.9) comparison. Results We found is feasible in new peridevice...
Abstract Aims Atrial fibrillation (AF) is one of the major causes ischaemic stroke. In addition to clinical risk evaluated by CHA2DS2-VASC score, impact genetic factors on AF-related thromboembolic stroke has been largely unknown. We found several copy number variations (CNVs) in novel genes that were associated with our AF patients genome-wide approach. Among them, gasdermin D (GSDMD) gene was related inflammation. aimed test whether GSDMD deletion Methods and results A total 400 documented...
Abstract Combination use of digoxin and other medications might lead to worse outcomes in patients with atrial fibrillation (AF). We sought investigate whether digoxin-amiodarone combination would outcome than alone AF. Adult AF received treatment from random samples 1,000,000 individuals covered by the National Health Insurance Taiwan were included. Baseline characteristics including risk factors matched propensity score (PS) those without addition amiodarone treatment. A total 5,040 taking...