A5068573722- Proteoglycans and glycosaminoglycans research
- Cardiovascular Effects of Exercise
- Protease and Inhibitor Mechanisms
- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
- Glycosylation and Glycoproteins Research
- Virus-based gene therapy research
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Ion Transport and Channel Regulation
- Cardiac Imaging and Diagnostics
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Inflammatory mediators and NSAID effects
- Advanced Breast Cancer Therapies
- Receptor Mechanisms and Signaling
- Estrogen and related hormone effects
- Eicosanoids and Hypertension Pharmacology
- MicroRNA in disease regulation
- Ion channel regulation and function
- Liver physiology and pathology
National Taiwan University
2021-2025
City Of Hope National Medical Center
2024
Institute of Biomedical Sciences, Academia Sinica
2018-2024
National Taiwan University Hospital
2023
University of California, San Diego
2023
Genomics (United Kingdom)
2023
Abstract Background Serglycin (SRGN), previously recognized as an intracellular proteoglycan involved in the storage processes of secretory granules, has recently been shown to be upregulated several solid tumors. We have that SRGN non-small cell lung cancer (NSCLC) promotes malignant phenotypes a CD44-dependent manner and increased expression predicts poor prognosis primary adenocarcinomas. However, underlying mechanism remains defined. Methods Overexpression, knockdown knockout approaches...
Abstract Peroxisome proliferator-activated receptor γ (PPARγ) is a master transcriptional regulator of systemic insulin sensitivity and energy balance. The anti-diabetic drug thiazolidinediones (TZDs) are potent synthetic PPARγ ligands with undesirable side effects, including obesity, fluid retention, osteoporosis. 15-keto prostaglandin E2 (15-keto-PGE2) an endogenous ligand metabolized by reductase 2 (PTGR2). Here, we confirmed that 15-keto-PGE2 binds to activates via covalent binding. In...
Background: Among various bio-informative molecules transferred by exosomes between cells, micro RNAs (miRNAs), which remain remarkably stable even after freeze-and-thaw cycles, are excellent candidates for potential biomarkers coronary artery disease (CAD). Methods: Blood samples were collected from the arteries of 214 patients diagnosed with three-vessel CAD and 140 without CAD. After precipitation extraction, amounts found to decrease increased age Next-generation sequencing was performed...
Exosomes are membrane vesicles that actively secreted in response to microenvironmental stimuli. In this study, we quantified the amount of exosomes patients with significant coronary artery disease (CAD) and evaluated its relationship myocardial perfusion imaging (MPI) results.
Peroxisome proliferator-activated receptor γ (PPARγ) is a master transcriptional regulator of systemic insulin sensitivity and energy balance. The anti-diabetic drug thiazolidinediones (TZDs) are potent synthetic PPARγ ligands with undesirable side effects, including obesity, fluid retention, osteoporosis. 15-keto prostaglandin E2 (15-keto-PGE2) an endogenous ligand metabolized by reductase 2 (PTGR2). Here, we confirmed that 15-keto-PGE2 binds activates via covalent binding. In patients type...
Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genetic variants to atherosclerotic cardiovascular diseases and serum lipoprotein levels. However, how regulates blood pressure is unknown.To identify associated with pressure, we performed a genome-wide linkage analysis regional fine mapping in the Stanford Asia-Pacific Program for Hypertension Insulin Resistance (SAPPHIRe) cohort. We further investigated role of gene using transgenic mouse model human...
Abstract Objectives Exosomes are membrane vesicles that actively secreted in response to microenvironmental stimuli. In this study, we quantified the amounts of exosomes patients with significant coronary artery disease (CAD) and evaluated its relationship myocardial perfusion imaging (MPI). Methods Patients who underwent both MPI angiography were recruited. Plasma was collected during extracted by precipitation method. The scores ventricular functional parameters calculated from compared...
Abstract Insulin resistance and obesity are pivotal features of type 2 diabetes mellitus. Peroxisome proliferator-activated receptor γ (PPARγ) is a master transcriptional regulator systemic insulin sensitivity energy balance. The anti-diabetic drug thiazolidinediones potent synthetic PPARγ ligands sensitizers with undesirable side effects including increased adiposity, fluid retention, osteoporosis, which limit their clinical use. We others have proved that 15-keto-PGE2 an endogenous natural...
Abstract Tumor microenvironment (TME) plays an important role in cancer progression. We have recently shown that serglycin (SRGN), a chondroitin sulfate proteoglycan (CSPG), is overexpressed primary non-small cell lung cancers (NSCLCs), by carcinoma as well stromal cells, and the secreted SRGN can bind to CD44 promotes NSCLC aggressiveness (Oncogene 36:2457, 2007). In this study, we further examined molecular mechanisms underlying SRGN-elicited migration. By gain- loss-of-function studies,...