A5048695746- Radiomics and Machine Learning in Medical Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- EEG and Brain-Computer Interfaces
- Acute Ischemic Stroke Management
- Extracellular vesicles in disease
- Gastric Cancer Management and Outcomes
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Lymphatic System and Diseases
- Science Education and Pedagogy
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Visual and Cognitive Learning Processes
- Alzheimer's disease research and treatments
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Neurosurgical Procedures and Complications
- Cardiovascular Effects of Exercise
National Taiwan University Hospital
2016-2025
Memorial Sloan Kettering Cancer Center
2018-2023
National Kaohsiung Normal University
2011-2023
University of California, San Diego
2023
Genomics (United Kingdom)
2023
National Yunlin University of Science and Technology
2016-2020
National Taiwan University
2013-2016
Far Eastern Memorial Hospital
2016
National Yang Ming Chiao Tung University
2016
California Polytechnic State University
2015
Volumetric lung tumor segmentation and accurate longitudinal tracking of volume changes from computed tomography images are essential for monitoring response to therapy. Hence, we developed two multiple resolution residually connected network (MRRN) formulations called incremental-MRRN dense-MRRN. Our networks simultaneously combine features across image feature levels through residual connections detect segment the tumors. We evaluated our method on a total 1210 non-small cell (NSCLC)...
To develop a radiomics prediction model to improve pulmonary nodule (PN) classification in low-dose CT. compare the with American College of Radiology (ACR) Lung CT Screening Reporting and Data System (Lung-RADS) for early detection lung cancer.We examined set 72 PNs (31 benign 41 malignant) from Image Database Consortium image collection (LIDC-IDRI). One hundred three radiomic features were extracted each PN. Before building process, distinctive identified using hierarchical clustering...
Abstract Lobar cerebral microbleeds are a characteristic neuroimaging finding in amyloid angiopathy (CAA) but can also be found hypertensive arteriolosclerosis. We aimed to investigate whether CAA is more associated with intracortical lobar than arteriosclerosis. Ninety-one survivors of spontaneous intracerebral hemorrhage at least one microbleed were included and underwent brain MRI PET. categorized as intracortical, juxtacortical, or subcortical. assessed the associations between...
Although amyloid positron emission tomography (PET) might provide a molecular diagnosis for cerebral angiopathy (CAA), it does not have sufficient specificity this condition relative to incipient Alzheimer's disease (AD). To identify regional uptake pattern specific CAA, we attempted reduce overlap by selecting "pure CAA" (i.e., fulfilling the criteria probable CAA but without tau PET AD signature) and AD" positive presence of signature, lobar hemorrhagic lesions). We hypothesized that...
This study determined the prognostic value of volumetric parameters derived from pretreatment F-FDG and F-DOPA PET/CT neuroblastoma their correlation with clinical histopathologic features.A total 25 children underwent within 4 weeks. The SUVmax primary tumors on PET were recorded as SUVFDG SUVDOPA, respectively. For tumors, 40% was used to generate volume interest. If below 2.5, an SUV threshold 2.5 instead. Metabolic tumor (MTV), lesion glycolysis (TLG), dopaminergic (DTV), activity (TLDA)...
Digital video has become a popular instructional media, which makes students more enthusiastic about the subjects they are learning. However, may not be able to receive these benefits if videos present information contain too quickly. To overcome this problem, study proposed annotation learning system, by learners can annotate and highlight interesting or important contents make them memorable. A quasi-experiment was conducted on cardiopulmonary resuscitation course evaluate effectiveness of...
Autoimmune pancreatitis (AIP) shares overlapping clinical features with pancreatic cancer (PC). Importantly, treatment of the two conditions is different. We investigated usefulness 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients suspected AIP before treatment. From September 2008 to July 2016, 53 at National Taiwan University Hospital had PET/CT prior therapy exclude malignancy and evaluate extent inflammation. Their scans were compared...
We proposed a framework to detect and quantify local tumor morphological changes due chemo-radiotherapy (CRT) using Jacobian map extract quantitative radiomic features from the predict pathologic response in locally advanced esophageal cancer patients. In 20 patients who underwent CRT, multi-resolution BSpline deformable registration was performed register follow-up (post-CRT) CT baseline image. The (J) computed as determinant of gradient deformation vector field. measured ratio volume...
Purpose The aim of this study was to investigate whether the textural features pretreatment 18F-FDG PET images can predict prognosis for nasal type extranodal natural killer/T-cell lymphoma (ENKTL). Materials and Methods A retrospective analysis patients with newly diagnosed ENKTL from 2008 2013 conducted. Progression-free survival (PFS) main outcome measure. primary tumor identified then delineated using 40% maximum standardized uptake value (SUVmax) thresholding method. were extracted....
Lung adenocarcinoma (ADC) is the most common non-small cell lung cancer. Surgical resection primary treatment for early-stage ADC while lung-sparing surgery an alternative non-aggressive cases. Identifying histopathologic subtypes before helps determine optimal surgical approach. Predominantly solid or micropapillary (MIP) are aggressive and associated with a higher likelihood of recurrence metastasis lower survival rates. This study aims to non-invasively identify these using preoperative...
Abstract Tau, a hallmark of Alzheimer’s disease, is poorly characterized in cerebral amyloid angiopathy. We aimed to assess the clinico-radiological correlations between tau positron emission tomography scans and assessed hyperphosphorylated patients with probable angiopathy (n = 31) hypertensive small vessel disease 27) using 11C-Pittsburgh compound B 18F-T807 tomography. Multivariable regression models were employed radio-clinical features related pathology Cerebral exhibited higher burden...
ABSTRACT Background Blood‐based biomarkers may offer a non‐invasive approach to diagnose cerebral amyloid angiopathy (CAA), especially in early‐stage. We evaluated the ability of plasma phosphorylated tau‐217 (p‐tau 217) differentiate CAA from Alzheimer's disease (AD) and deep perforator arteriopathy (DPA). Methods Patients with AD (age 73.7 ± 8.1 years), probable (74.8 6.9 or DPA (66.1 10.4 years) were enrolled memory stroke clinics at medical center Taiwan. All participants received tau...
Coronary artery disease (CAD) is a leading cause of cardiovascular morbidity and mortality. Exosomal microRNAs (miRNAs) play role in vascular atherosclerosis are involved the pathophysiology CAD. This study aimed to validate associations eight exosomal miRNAs with CAD assess their relevance severity. A total 875 participants who underwent elective coronary angiography were enrolled between January 2022 August 2023. Blood samples collected during angiography, analyzed using quantitative...
ABSTRACT Background Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive dysfunction in the elderly, frequently coexists with Alzheimer's disease tau pathology. Dual‐phase 11 C‐PiB PET detects deposition cerebral perfusion changes may have diagnostic value for identifying CAA. Methods We prospectively enrolled patients probable CAA dynamic PiB AV1451 scans. compared early‐phase (0–6 min after tracer injection) late‐phase (40–70 min) between...
Background: Among various bio-informative molecules transferred by exosomes between cells, micro RNAs (miRNAs), which remain remarkably stable even after freeze-and-thaw cycles, are excellent candidates for potential biomarkers coronary artery disease (CAD). Methods: Blood samples were collected from the arteries of 214 patients diagnosed with three-vessel CAD and 140 without CAD. After precipitation extraction, amounts found to decrease increased age Next-generation sequencing was performed...
Excessive Internet use is associated with a limited ability to communicate effectively socially, which depends largely on the capacity for perception of human face. We used passive visual detection paradigm compare early stages processing face-related information in young excessive users (EIUs) and healthy normal subjects by analyzing event-related potentials (ERPs) elicited faces nonface stimuli (tables), each presented upright inverted position. The P1 N170 components spectrum ERPs at...
We assessed the impact of a multidisciplinary team care program on treatment outcomes in neuroblastoma patients. Newly diagnosed patients received under Taiwan Pediatric Oncology Group (TPOG) N2002 protocol at National University Hospital beginning 2002. A approach that included nurse-led case management for treated this began January 2010. Fifty-eight patients, including 29 between 2002 and 2009 (Group 1) 2010 2014 2), were enrolled study. The 5-year overall survival (OS) event-free (EFS)...
The recovery of gallium (Ga) from arsenide (GaAs) scrap using a leaching-ion exchange method was investigated. ground GaAs leached, 2.0 N nitric acid at 30 °C for 1.0 h, and the dissolution Ga arsenic (As) reached 98%. pregnant solution with 1/20 dilution ratio then passed through weak chelating resin Diaion CR-11. Highly charged Ga3+ has ability to form complexes separate coexisting H3AsO4 in leachate very low pH. loaded column eluted 0.1 M H2SO4, final concentrated had 4.5 g/L 99.3%...
Abstract Teachers often use in‐class questions to examine the level of understanding their students, while these also enable students reorganize acquired knowledge. However, previous studies have shown that may resist being questioned because negative emotions. Therefore, this paper proposes idea eliciting positive emotions by showing funny images reward them for providing correct answers. Three were conducted with different courses, using either a video lecture or classroom lecture. The...
Brainwave signals are analyzed in the nonlinear analysis field and often studied by electroencephalography (EEG) using brain sensors.Although various frequency bands of brainwaves, such as α, β, θ can be filtered out from multi-frequency brainwave signals, most modern medicine only interprets meaning superficially rarely conducts an in-depth quantitative data.In this study, we selected healthy adults to experimentally analyze their sleep three stages: before sleep, during awakening after...
To investigate the association between cerebral amyloid deposition and long-term cognitive outcomes in patients with hemorrhagic small vessel disease (SVD) survivors of intracerebral hemorrhage (ICH).Patients experiencing an ICH without overt dementia were prospectively recruited (n = 68) for brain MRI Pittsburgh compound B (PiB) positron emission tomography scans at baseline. Cognitive function was assessed using mini-mental status examination (MMSE) clinical rating after overall median...
<p style="text-align:justify">The purpose of this study was to investigate how mental rotation strategies affect the identification chemical structural formulas. This conducted event-related potentials (ERPs) experiments. In addition data collected in ERPs, a Chemical Structure Conceptual Questionnaire and interviews were also administered for collection. Eighteen university students majoring chemistry recruited. ERP experiments, participants required identify 2D figures, formulas, 3D...
Purpose Myocardial perfusion imaging (MPI) using gated single-photon emission tomography (gSPECT) may underestimate the severity of coronary artery disease (CAD). This study aimed to evaluate significance combined parameters derived from gSPECT, as well treadmill stress test parameters, in detection severe CAD. Methods A total 211 consecutive patients referred for exercise MPI between June 2011 and 2013 (who received invasive angiography within six months after MPI) were retrospectively...