A5005582451- Diabetes Management and Education
- Biomarkers in Disease Mechanisms
- Genetic Associations and Epidemiology
- Inflammasome and immune disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
National Taiwan University
2023-2025
China-Japan Friendship Hospital
1997
OBJECTIVE To determine the prevalence of diabetes and impaired glucose tolerance (IGT) its risk factors in Chinese population. RESEARCH DESIGN AND METHODS This study was a population-based cross-sectional 224,251 residents aged 25–64 years 19 provinces areas, including cities rural areas north, south, east, middle part China. RESULTS Using 1985 World Health Organization criteria, IGT 2.5 3.2%, respectively, 213,515 subjects years. Two thirds (70.3%) cases had newly recognized diabetes. The...
Genome-wide association studies (GWASs) identified common single nucleotide polymorphisms (SNPs) in more than 100 genomic regions associated with atrial fibrillation (AF). We aimed to identify novel AF genes Taiwanese population by multi-stage GWAS. In exploratory stage, we did GWAS whole genome genotypes (4,512,191 SNPs) 516 Patients from National Taiwan University registry (NTUAFR) and 5160 normal sinus rhythm controls Biobank. Significant loci were replicated 1002 independent patients...
Abstract Aims Atrial fibrillation (AF) is one of the major causes ischaemic stroke. In addition to clinical risk evaluated by CHA2DS2-VASC score, impact genetic factors on AF-related thromboembolic stroke has been largely unknown. We found several copy number variations (CNVs) in novel genes that were associated with our AF patients genome-wide approach. Among them, gasdermin D (GSDMD) gene was related inflammation. aimed test whether GSDMD deletion Methods and results A total 400 documented...