A5049654357- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Liver Disease and Transplantation
- Atrial Fibrillation Management and Outcomes
- Microfluidic and Capillary Electrophoresis Applications
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Heart Rate Variability and Autonomic Control
- Cardiac Arrest and Resuscitation
- Drug-Induced Hepatotoxicity and Protection
- Analytical Chemistry and Chromatography
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Receptor Mechanisms and Signaling
- Autophagy in Disease and Therapy
- Innovative Microfluidic and Catalytic Techniques Innovation
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Acute Myocardial Infarction Research
- Neuroscience and Neural Engineering
- Climate Change and Health Impacts
- RNA and protein synthesis mechanisms
National Taiwan University Hospital
2013-2025
National Taiwan University
1988-2024
Chang Gung Memorial Hospital
2023
National Cheng Kung University
2012-2016
Taipei Veterans General Hospital
2002-2012
National Yang Ming Chiao Tung University
2002-2012
China Medical University Hospital
2011
China Medical University
2011
National Yang Ming University Hospital
2009-2010
To evaluate the correlation between atrial fibrillation (AF) burden and two-dimensional LA (left atrium) longitudinal reservoir strain (LARS) to explore potential clinical utility of this novel parameter in patients with AF. This cross-sectional study was conducted at cardiac electrophysiology clinic a tertiary centre by consecutively enrolling non-valvular The AF evaluated using 14-day patch-based electrocardiography defined as percentage time spent during monitoring period. High low...
Current hemodialysis has functional limitations and is insufficient for renal transplantation. The bioartificial tubule device been developed to contribute metabolic functions by implanting epithelial cells into hollow tubes showed a higher survival rate in acute kidney injury patients. In healthy kidney, are surrounded various types of that interact with extracellular matrices, which primarily composed laminin collagen. current study microfluidic coculture platform enhance cell function...
Extracorporeal life support (ECLS) can temporarily cardiopulmonary function, and is occasionally used in resuscitation. Multi-scale entropy (MSE) derived from heart rate variability (HRV) a powerful tool outcome prediction of patients with cardiovascular diseases. symbolic analysis (MSsE), new method MSE, mitigates the effect arrhythmia on analysis. The objective to evaluate prognostic value MSsE receiving ECLS. primary death or urgent transplantation during index admission. Fifty-seven ECLS...
This study was designed to assess the clinical effect of a home-based telephone intervention in Chinese heart failure patients. A total 550 patients were enrolled into either (i) group that received usual standard care (UC group); or (ii) centre management programme using nursing specialist-led consultations (HFC group). The impact on admission rate, length and medical costs over 6 months measured. Although mean left ventricular ejection fraction HFC 29.3% compared with 34.8% UC patients,...
Background: Brugada syndrome (BrS) is an oligogenic arrhythmic disease with increased risk of sudden cardiac arrest. Several BrS or ECG traits-related single-nucleotide polymorphisms (SNPs) were identified through previous genome-wide association studies in white patients. We aimed to validate these SNPs patients the Taiwanese population, assessing cumulative effect alleles and BrS-polygenic score predicting events. Methods: genotyped 190 unrelated using TWB Array, Taiwan Biobank was used as...
BackgroundBrugada syndrome (BrS) is a rare inherited disease causing sudden cardiac death (SCD). Copy number variants (CNVs) can contribute to susceptibility, but their role in Brugada unknown. We aimed identify CNV associated with BrS and elucidated its clinical implications.MethodsWe enrolled 335 unrelated patients from 2000 2018 the Taiwanese population. Microarray exome sequencing were used for discovery phase whereas Sanger was validation phase. HEK cells zebrafish characterize function...
Abstract Aims The electrical properties of N a + ‐activated K current ( I K(Na) ) and its contribution to spike firing has not been characterized in motor neurons. Methods We evaluated how activation voltage‐gated at the cellular level could be coupled Na influx through two neuron‐like cells NG 108‐15 NSC ‐34 cells). Results Increasing stimulation frequency altered amplitudes both simultaneously. With changes frequency, kinetics inactivation were well correlated same cell. Addition...
Portal-systemic collateral vascular resistance and vasoconstrictor responsiveness are crucial in portal hypertension variceal bleeding control. Statins enhance vasodilators production, but their influence on collaterals is unknown. This study aimed to survey the effect of simvastatin collaterals.Partially vein-ligated rats received oral (20 mg/kg/day) or distilled water from -2 +7 day ligation. After hemodynamic measurements eighth postoperative day, baseline perfusion pressure (i.e. an...
In this work, we developed processes to biofunctionalize magnetic nanoparticles dispersed in phosphate buffer saline solution. For future clinical utility, were biofunctionalized with anti-vascular cell adhesion molecule-1 (VCAM-1) label the VCAM-1 molecule, which served as an indicator for lesions prone vulnerable atherosclerotic plaque formation. The used magnetically label, vitro, cells expressing VCAM-1, well locate aortic of hypercholesterolemic rabbits aid resonance imaging. addition...
Brugada syndrome (BrS) is a heritable disease that results in sudden cardiac death. In the exome/genomic era, certain reported pathogenic variants some genetic diseases have been reclassified as benign owing to their high frequency ancestries. present study, we comprehensively reassessed all previously of BrS. We collected BrS Human Gene Mutation Database and ClinVar throughout April 2017. compared minor allele (MAF) each variant among different ancestries by searching public whole-genome...
Obstructive sleep apnea (OSA) is a risk factor for atrial fibrillation (AF); however, it unclear whether AF increases the of OSA. Furthermore, sex differences among patients with both and OSA remain unclear. We aimed to determine association between an increased burden investigate in clinical characteristics women men This was descriptive, cross-sectional analysis from prospective cohort study. Patients non-valvular were recruited cardiac electrophysiology clinic tertiary center; they...
Chromosome number and nuclear behavior in mesophyll protoplasts isolated from haploid plants of Nicotiana plumbaginifolia sylvestris were investigated during the process plant regeneration. At first mitotic division, a great majority nuclei had chromosomes. Of these, 10.4% N. 3.5% contained diplochromosomes, indicating that endoreduplication occurred. In subsequent divisions, however, only two-chromatid chromosomes present. One other abnormality observed few days culture was formation di-...
The objective was to investigate the prognostic value of T-wave morphology in systolic heart failure patients. descriptors on standard 12-lead electrocardiograms (ECG) have been shown importance concerning arrhythmic susceptibility patients with previous myocardial infarction. However, these not considered regard further risk stratification failure.Patients [defined by a left ventricular ejection fraction (LVEF) <50%] were enrolled. Standard digitized ECGs used for analysis [lead dispersion,...
Background: Electrophysiological information as well anatomic are important for the detection of coronary artery lesions. The aim this study was to assess efficacy resting magnetocardiography (MCG) in stable disease (CAD) and cardiac allograft vasculopathy (CAV). Methods Results: MCG angiography were performed within 1 month 75 patients with suspected CAD 26 subjects after orthotopic heart transplantation (OHT). Plaque volumes additionally measured on intravascular ultrasound OHT recipients....
Abstract Little is known regarding the interplays between mechanical and molecular bases for vein graft restenosis. We elucidated stenosis initiation using a high-frequency ultrasonic (HFU) echogenicity platform estimated endothelium yield stress from von-Mises computation to predict damage locations in living rats over time. The venous-arterial transition induced cascades autophagy apoptosis venous endothelial cells (ECs) cause neointimal hyperplasia, which correlated with high HFU images...
Abstract Aims Left bundle branch block (LBBB) is associated with an increased risk of adverse outcomes for patients heart failure. The prognosis LBBB in a preserved ejection fraction (EF) remains controversial. This study investigated the predictive value T‐wave discordance and or mildly reduced EF. Methods results We enrolled 707 complete left ventricular (LV) EF ≥ 40% observed using electrocardiograms (ECGs) echocardiograms between January 2010 December 2018. Their serial ECGs were...
Eur J Clin Invest 2012; 42 (12): 1309–1316 Abstract Background Sorafenib, a multikinase inhibitor that inhibits angiogenesis and carcinogenesis, has been used for patients with advanced hepatocellular carcinoma. However, sporadic cases have reported the development of hepatic encephalopathy (HE) after sorafenib treatment, mostly in those cirrhosis. Liver function impairment, portal‐systemic collaterals brain oxidative stress participate pathogenesis HE. The study therefore aimed to...