A5047973810- Vagus Nerve Stimulation Research
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Neurological disorders and treatments
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Advanced Memory and Neural Computing
- Retinal Diseases and Treatments
- Advanced Fluorescence Microscopy Techniques
- Cardiac Arrhythmias and Treatments
- Transcranial Magnetic Stimulation Studies
- Nicotinic Acetylcholine Receptors Study
- Face and Expression Recognition
- Face recognition and analysis
- Urinary Bladder and Prostate Research
- Blind Source Separation Techniques
- Pain Management and Treatment
- Aortic aneurysm repair treatments
- Video Surveillance and Tracking Methods
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Aortic Disease and Treatment Approaches
- Cardiac pacing and defibrillation studies
Medtronic (United States)
2010-2024
Feinstein Institute for Medical Research
2018-2023
Northwell Health
2019-2023
University of Southern California
2016-2017
Xiaomi (China)
2014
Research Center for Information Technology Innovation, Academia Sinica
2013
National Yang Ming Chiao Tung University
2011
National Yang Ming University Hospital
2011
Cervical vagus nerve stimulation (VNS) is an emerging bioelectronic treatment for brain, metabolic, cardiovascular and immune disorders. Its desired off-target effects are mediated by different fiber populations knowledge of their engagement could guide calibration monitoring VNS therapies.Stimulus-evoked compound action potentials (eCAPs) directly provide information but currently not feasible in humans. A method to estimate through common, noninvasive physiological readouts be used place...
Objective. Retinal prosthetic implants restore partial vision to patients blinded due outer retinal degeneration, using a camera-guided multielectrode array (MEA) that electrically stimulates surviving neurons. Commercial epi-retinal prostheses use millisecond-scale charge-balanced, symmetric, cathodic-first biphasic pulses depolarize ganglion cells (RGCs) and bipolar (BCs), frequently creating oblong perceptions of light related axonal activation RGCs. Stimulation strategies avoid...
Abstract Vagus nerve stimulation (VNS) is a bioelectronic therapy for disorders of the brain and peripheral organs, tool to study physiology autonomic circuits. Selective activation afferent or efferent vagal fibers can maximize efficacy minimize off-target effects VNS. Anodal block (ABL) has been used achieve directional fiber in stimulation. However, evidence VNS with ABL scarce inconsistent, it unknown whether permits respect functional Through series vagotomies, we established...
Vagus nerve stimulation (VNS) suppresses inflammation and autoimmune diseases in preclinical clinical studies. The underlying molecular, neurological, anatomical mechanisms have been well characterized using acute electrophysiological of the vagus. However, there are several unanswered mechanistic questions about effects chronic VNS, which require solving numerous technical challenges for a long-term interface with vagus mice. Here, we describe scalable model VNS mice developed validated...
Abstract Objective. Vagus nerve stimulation (VNS) is typically delivered at increasing stimulus intensity until a neurological or physiological response observed (‘threshold’) for dose calibration, preclinically and therapeutically. Factors affecting VNS thresholds have not been studied systematically. In rodent model of we measured neural responses to intensity, determined examined the effect implant- anesthesia-related factors on thresholds. Approach. acute chronic vagus implants (45 20...
BACKGROUND AND OBJECTIVES: Deep brain stimulation (DBS) has developed into an effective therapy for several disease states including treatment-resistant Parkinson and medically intractable essential tremor, as well segmental, generalized cervical dystonia, obsessive-compulsive disorder (OCD). Dystonia OCD are approved with Humanitarian Device Exemption. In addition, DBS is also the treatment of epilepsy in anterior nucleus thalamus. Although overall considered epilepsy, a number specific...
Automatic spike sorting is a prerequisite for neuroscience research on multichannel extracellular recordings of neuronal activity. A novel framework, combining efficient feature extraction and an unsupervised clustering method, described here. Wavelet transform (WT) adopted to extract features from each detected spike, the Kolmogorov-Smirnov test (KS test) utilized select discriminative wavelet coefficients extracted features. Next, single linkage method based grey relational analysis (GSLC)...
The Secura ICD and Consulta CRT-D are the first defibrillators to have automatic right atrial (RA), ventricular (RV), left (LV) capture management (CM). Complete CM was evaluated in an implantable cardioverter defibrillator (ICD) population.Two prospective clinical studies were conducted 28 centres Europe Israel. Automatic data compared with manual threshold measurements, applicability determined, adjustments pacing outputs analysed. In total, 160 patients [age 64.6 +/- 10.4 years, 77% male,...
Afferent and efferent fibers in the vagus nerve travel inside fascicles form branches to innervate organs regulate organ functions. The spatial organization of fascicles, with respect functions they mediate innervate, is unknown. Accordingly, it unknown whether such can be leveraged by bioelectronic devices for function- organ-specific neurostimulation. To characterize functional microscopic anatomy nerve, we developed a pipeline consisting micro-computed tomography 3D reconstruction...
Cervical vagus nerve stimulation (VNS) is a neuromodulation therapy for the treatment of several chronic disorders. The effects VNS are mediated by activation fibers different types. In order to maximize desired and minimize undesired VNS, assessing vagal fiber types essential. Evoked compound action potentials (CNAPs) commonly used as method estimate in context neurostimulation. However, CNAPs frequently contaminated signals from non-neural sources, like electrocardiography (ECG), stimulus...
Retinal prostheses improve vision for patients with retinal degeneration. However, the shape recognition ability of users is limited due to low visual resolution these devices. Off-target ganglion cell (RGC) activation an important contributing factor stimulation precision. Previous research has shown RGC spatial activity and perception shapes by can be difficult predict complexity retina structure electrode-retina interactions. In this study we demonstrate a method iteratively search...
Abstract Vagal fibers travel inside fascicles and form branches to innervate organs regulate organ functions. Vagus nerve stimulation (VNS) therapies activate non-selectively, often resulting in reduced efficacy side effects from non-targeted organs. Transverse longitudinal arrangement of according functions they mediate is unknown, however it crucial for selective VNS. Using microcomputed tomography, we found that, swine, are arranged 2 overlapping axes, with sensory motor separated...
Abstract Objective Neurostimulation is emerging as treatment for several diseases of the brain and peripheral organs. Due to variability arising from placement stimulation devices, underlying neuroanatomy physiological responses stimulation, it essential that neurostimulation protocols are personalized maximize efficacy safety. Building such would benefit accumulated information in increasingly large datasets other individuals’ responses. Approach To address need, we propose a meta-learning...
Objective. Virus-transduced, intracellular-calcium indicators are effective reporters of neural activity, offering the advantage cell-specific labeling. Due to existence an optimal time window for expression calcium indicators, a suitable tool tracking GECI in vivo following transduction is highly desirable. Approach. We developed noninvasive imaging approach based on custom-modified, low-cost fundus viewing system that allowed us monitor and characterize bright-field fluorescence images...
Abstract Vagus nerve stimulation (VNS) is a neuromodulation therapy with the potential to treat wide range of chronic conditions in which inflammation implicated, including type 2 diabetes, obesity, atherosclerosis and heart failure. Many these diseases have well-established mouse models but due significant surgical engineering challenges that accompany reliable interface for long-term VNS mice, therapeutic implications this bioelectronic approach remain unexplored. Here, we describe implant...
Patch clamp recordings of neurons in the inner nuclear layer retina are difficult to conduct a whole mount preparation because surrounding block path patch pipette. Vertical slice preparations or dissociated retinal cells provide access bipolar at cost severing lateral connection between neurons. We have developed technique remove photoreceptors from rodent that exposes neurons, allowing for recording. Repeated application and removal filter paper photoreceptor side an isolated effectively...
Abstract Vagus nerve stimulation (VNS) is used as therapy in epilepsy and depression tested a potential treatment for several chronic disorders. Typically, VNS delivered at increasing stimulus intensity until response observed (threshold intensity). Factors that affect threshold intensities engagement of different fiber types concomitant physiological responses have not been studied. We determined neural to anesthetized awake animals, examined the effect implant- anesthesia-related factors...
Retinal prosthetic implants have shown potential to restore partial vision patients blinded by retinitis pigmentosa or dry age-related macular degeneration, via a camera-driven multielectrode array that electrically stimulates surviving retinal neurons. Commercial epi-retinal prostheses mostly use charge-balanced symmetric cathodic-first biphasic pulses depolarize ganglion cells (RGCs) and bipolar (BCs), resulting in the perception of light blind patients. However, previous clinical study...
Research applications in the field of bioelectronic medicine require miniaturized electronics for neurostimulation featuring high precision, long lifetimes, and small size. Existing devices are often limited by battery capacity, durability biocompatible packaging, and/or an experimental setup that restricts subject motion. To improve on these limitations, a neurostimulator chronic implantation mice was designed using standard off-the-shelf components experimentally validated acutely vivo....
Cervical vagus nerve stimulation (VNS) is a neuromodulation therapy used in the treatment of several chronic disorders. In order to maximize therapeutic effectiveness VNS, it has become increasingly important deliver fiber-specific neurostimulation, so that undesired effects can be minimized. Assessing activation different vagal fiber types through electrical therefore essential for developing fiber-selective VNS therapies. Towards this goal, we conducted silico investigations using generic...