A5020374280- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Advanced Memory and Neural Computing
- Retinal Development and Disorders
- Industrial Vision Systems and Defect Detection
- Interdisciplinary Research and Collaboration
- Biomedical and Engineering Education
- Integrated Circuits and Semiconductor Failure Analysis
- Neural dynamics and brain function
University of Michigan
2018-2024
BioSurfaces (United States)
2019-2020
Michigan United
2020
Multielectrode arrays for interfacing with neurons are of great interest a wide range medical applications. However, current electrodes cause damage over time. Ultra small carbon fibers help to address issues but controlling the electrode site geometry is difficult. Here we propose methodology create small, pointed fiber (SPFe). We compare SPFe previously made blowtorched in characterization. The result sizes (105.4 ± 20.8 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Objective. Retinal prosthetic implants restore partial vision to patients blinded due outer retinal degeneration, using a camera-guided multielectrode array (MEA) that electrically stimulates surviving neurons. Commercial epi-retinal prostheses use millisecond-scale charge-balanced, symmetric, cathodic-first biphasic pulses depolarize ganglion cells (RGCs) and bipolar (BCs), frequently creating oblong perceptions of light related axonal activation RGCs. Stimulation strategies avoid...
Retinal prosthetic implants have helped improve vision in patients blinded by photoreceptor degeneration. implant users report improvements light perception and performing visual tasks, but their ability to perceive shapes letters is limited due the low precision of retinal activation, which exacerbated axonal stimulation high perceptual thresholds. A previous vitro study our lab used calcium imaging measure spatial activity mouse ganglion cells (RGCs) response electrical stimulation. Based...
Retinal prostheses partially restore vision in patients blinded by retinitis pigmentosa (RP) and age-related macular degeneration (AMD). One issue that limits the effectiveness of retinal stimulation is desensitization retina response to repeated pulses. Rapid fading percepts reported clinical studies. We studied output evoked fixed pulse trains vs. have variable parameters pulse-to-pulse. used current clamp record RGC spiking isolated mouse retina. Trains biphasic pulses at different...
Retinal prostheses aim to improve visual perception in patients blinded by photoreceptor degeneration. However, shape and letter with these devices is currently limited due low spatial resolution. Previous research has shown the retinal ganglion cell (RGC) activity phosphene shapes can vary complexity of retina structure electrode-retina interactions. Visual percepts elicited single electrodes differ size for different within same subject, resulting interference between phosphenes an unclear...
Retinal prostheses improve vision for patients with retinal degeneration. However, the shape recognition ability of users is limited due to low visual resolution these devices. Off-target ganglion cell (RGC) activation an important contributing factor stimulation precision. Previous research has shown RGC spatial activity and perception shapes by can be difficult predict complexity retina structure electrode-retina interactions. In this study we demonstrate a method iteratively search...
Retinal prostheses can improve vision for patients blinded by photoreceptor degenerative diseases. Despite the benefits of artificial vision, low spatial resolution these limits positive impact clinically available devices. Visual percepts generated single electrodes in epiretinal and subretinal implants overlap result an unclear image, which shape letter perception retinal prosthesis users. However, research suggests higher may be possible with smaller implanted intraretinally, close...
The Biointerfaces Interlaboratory Committees, the student organization for Institute at University of Michigan, organized and executed an 8 hour “BioHackathon” on broadly defined clinical topic ‘Aging.’ event began with experts in field (a clinician engineer) highlighting areas greatest need which engineers could improve lives aging population. Attendees separated into teams based shared interests pursuing specific needs, rapidly developed statements solution models to help elderly....