A5008767631- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Glycogen Storage Diseases and Myoclonus
- Motor Control and Adaptation
- Vestibular and auditory disorders
- Autoimmune Neurological Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological and metabolic disorders
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- Stroke Rehabilitation and Recovery
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Mitochondrial Function and Pathology
- Acute Ischemic Stroke Management
- Glioma Diagnosis and Treatment
- Neural and Behavioral Psychology Studies
- Musculoskeletal pain and rehabilitation
- Amino Acid Enzymes and Metabolism
- RNA regulation and disease
First Affiliated Hospital of Wannan Medical College
2025
Fourth Affiliated Hospital of Guangxi Medical University
2025
Nanjing Medical University
2025
China Medical University Hospital
2014-2024
China Medical University
2014-2024
Meizhou City People's Hospital
2023
Goethe University Frankfurt
2008-2015
China Medical University
2012-2015
National Yang Ming Chiao Tung University
2012-2013
Homeostatic metaplasticity, a fundamental principle for maintaining overall synaptic weight in the physiological range neuronal networks, was demonstrated at cellular and systems level predominantly excitatory neurotransmission. Although inhibitory networks are crucial regulating excitability, it is largely unknown to what extent homeostatic metaplasticity of inhibition also exists. Here, we employed intermittent continuous transcranial magnetic theta burst stimulation (iTBS, cTBS) primary...
The supplementary motor area (SMA-proper) plays a key role in the preparation and execution of voluntary movements. Anatomically, SMA-proper is densely reciprocally connected to primary cortex (M1), but neuronal coordination within SMA-M1 network its modification by external perturbation are not well understood. Here we modulated using MR-navigated multicoil associative transcranial magnetic stimulation healthy subjects. Changes corticospinal excitability were assessed recording evoked...
Abstract The dorsal premotor cortex (PMd) is thought to play a significant role in movement preparation cued by sensory information rather than self‐initiated movements. evidence humans for this contention still circumstantial. Here we explored the effects of modulation PMd excitability decreasing 1 Hz repetitive transcranial magnetic stimulation (rTMS) versus increasing 5 rTMS on two forms related cortical potentials: contingent negative variation (CNV) Bereitschaftspotential (BP)...
The cerebellum is crucially important for motor control and adaptation. Recent non-invasive brain stimulation studies have indicated the possibility to alter excitability of its projections contralateral cortex, with behavioral consequences on Here we sought induce bidirectional spike-timing dependent plasticity (STDP)-like modifications cortex (M1) by application paired associative (PAS) in healthy subjects. Conditioning over right lateral (CB) preceded focal transcranial magnetic (TMS)...
Symptoms of essential tremor (ET) are similar to those Parkinson's disease (PD) during their initial stages. Presently, there few stable biomarkers available on a neuroanatomical level for distinguishing between these two diseases. However, investigations have directly compared the changes in brain volume and assessed compensatory effects change parts associated with PD ET. To determine and/or degenerative anatomical brains ET patients, present study tested, via VBM approaches (Basic vs....
The issue of stray animals on university campuses has become increasingly problematic, with traditional management models facing significant challenges. This paper applies service design theory to propose a hybrid online-offline system aimed at enhancing the campus ecosystem, managing animals, and promoting students’ mental health. Using co-creation methods, stakeholder analysis, tools such as in-depth interviews user experience mapping, study identifies needs, pain points, opportunities. A...
Stroke is the second-leading global cause of death. The damage attributed to immune storm triggered by ischemia–reperfusion injury (IRI) post-stroke substantial. However, data on transcriptomic dynamics pyroptosis in IRI are limited. This study aimed analyze expression key genes stroke and their correlation with infiltration. Pyroptosis-related were identified from obtained middle cerebral artery occlusion (MCAO) datasets. Differential functional analyses pyroptosis-related performed,...
We conducted a multicenter, partially randomized, platform trial to assess the effectiveness of booster dose an aerosolized or intramuscular adenovirus type 5 vectored COVID-19 vaccine (Ad5-nCoV) in Chinese adults (NCT05855408). Between May 23, 2023, and August 28, 4089 eligible participants were equally randomized receive either Ad5-nCoV via oral inhalation at 0.1 mL (IH Ad5-nCoV, n = 2039) injection 0.5 (IM 2050). Additionally, 2008 who declined but consented participate surveillance...
Po-Han Chou, Yen-Feng Lin, Ming-Kuei Lu, Hsin-An Chang, Che-Sheng Chu, Wei Hung Taishiro Kishimoto, Alexander T. Sack, Kuan-Pin Su. Clin Psychopharmacol Neurosci 2021;19:190-205. https://doi.org/10.9758/cpn.2021.19.2.190
Study Objective:Recently, the pathogenesis of Parkinson disease (PD) has been focused on microglial activation, especially subsequent increase cytokines. A body clinical evidence suggests that sleep is altered in patients with PD; however, there a lack understanding basic cellular mechanism. This study was designed to elucidate influence brain interleukin (IL)-1β changes, addition dopaminergic and γ-aminobutyric acid (GABA)-ergic systems, an animal PD model.
Abstract Patients with Parkinson’s disease (PD) suffer from motor and non-motor symptoms; 40% would develop dementia (PD-D). Impaired face emotion processing in PD has been reported; however, the deficits of PD-D remain unclear. We investigated three essential aspects capacity PD-D, associations between cognitive, neuropsychiatric assessments task performances. Twenty-four patients (mean age: 74.0 ± 5.55) eighteen age-matched healthy controls (HC) 71.0 6.20) received computerized tasks,...
We have previously found that sarcosine, a glycine transporter I inhibitor, can improve the psychiatric symptoms of schizophrenia. In this study, we aimed to investigate whether agent also ameliorate neuropsychiatric Parkinson's disease (PD) patients with dementia.An 8-week, double-blind, placebo-controlled trial was conducted in who had PD dementia (PD-D). Neuropsychiatric manifestations were measured before and at week 2 (V1), 4 (V2) 8 (V3) after treatment. Linear regression generalized...
Paired associative stimulation (PASLTP) of the human primary motor cortex (M1) can induce LTP-like plasticity by increasing corticospinal excitability beyond period. Previous studies showed that two consecutive PASLTP protocols interact homeostatic metaplasticity, but animal experiments provided evidence LTP be augmented repeated spaced ~30min. Here we tested in twelve healthy selected responders possibility M1 systematically varying interval between protocols. The first protocol (PAS1)...
Introduction: Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant, cerebellar degeneration predominant disease caused by excessive CAG repeats. We examined event-related dysynchronization/synchronization (ERD/ERS) in patients with SCA3. Methods: assessed ERD/ERS of self-paced voluntary hand movements 15 genetically proven SCA3 comparison healthy controls. Results: In ERS, a significant interaction effect between group, frequency, and period (F = 1.591; p 0.005; ρI 0.86) was...
Parkinson's disease (PD) and essential tremor (ET) are characterized with motor dysfunctions. Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like plasticity diffusion tensor imaging (DTI) of the corticospinal tract (CST). Three groups twelve subjects moderate severity PD, ET intention healthy controls (HC) were studied. The primary cortex (M1) excitability, measured evoked potential (MEP) amplitude...
We adopt the existing Deep learning architecture to support diagnosing acute ischemic stroke by automatically detecting lesion location on 3D non-contrast CT brain scans. also investigate feasibility of model's applications in clinical scenario data analysis. retrospectively collected scans 317 patients with from China Medical University Hospital. All underwent standard baseline scanning followed diffusion-weighted imaging. utilized these for training model – SwinUNETR, which includes a...
Little is known about the spatiotemporal dynamics of cortical responses that integrate slightly asynchronous somatosensory inputs from both hands. This study aimed to clarify timing and magnitude interhemispheric interactions during early integration bimanual information in different regions their relevance for object manipulation exploration. Using multi-fiber probabilistic diffusion tractography MEG source analysis conditioning-test (C-T) median nerve evoked fields healthy human subjects,...
Functional perturbation of the cerebellum (CB)-motor cortex (M1) interactions may underlie pathophysiology movement disorders, such as Parkinson's disease (PD) and spinocerebellar ataxia type 3 (SCA3). Recently, M1 motor excitability can be bidirectionally modulated in young subjects by corticocortical paired associative stimulation (PAS) on CB contralateral with transcranial magnetic (TMS), probably through cerebello-dentato-thalamo-cortical (CDTC) circuit. In this study, we investigated to...
Article Abstract Objective: To evaluate the influence of long-term zolpidem use on incidence developing Parkinson's disease. Method: 2,961 subjects who used for first time longer than 3 months between 1998 and 2000 were identified in National Health Insurance system Taiwan. Subjects without a history randomly selected as comparison cohort frequency matched to users based age, sex, index date. The diagnosis disease was criteria International Classification Diseases, Ninth Revision, Clinical...