A5017249011- Acute Ischemic Stroke Management
- Dementia and Cognitive Impairment Research
- Hormonal and reproductive studies
- Prostate Cancer Diagnosis and Treatment
- Neurological and metabolic disorders
- Urinary Bladder and Prostate Research
- Schizophrenia research and treatment
- Restless Legs Syndrome Research
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Stroke Rehabilitation and Recovery
- Dialysis and Renal Disease Management
- Menopause: Health Impacts and Treatments
- Retinoids in leukemia and cellular processes
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Bach Studies and Logistics Development
- Iron and Steelmaking Processes
- Gastrointestinal motility and disorders
- Amino Acid Enzymes and Metabolism
- Brain Tumor Detection and Classification
- Peripheral Neuropathies and Disorders
- Medicinal Plants and Neuroprotection
- Acne and Rosacea Treatments and Effects
China Medical University Hospital
2009-2024
China Medical University
2009-2024
China Medical University
2022
National Yang Ming Chiao Tung University
2015-2017
Shandong Institute of Automation
2017
China University of Geosciences
2017
The clinical dementia rating (CDR) scale is commonly used to diagnose due Alzheimer's disease (AD). sum of boxes the CDR (CDR-SB) has recently been emphasized and applied interventional trials for tracing progression cognitive impairment (CI) in early stages AD. We aimed study influence baseline CDR-SB on or reversion normal cognition (NC).
Several studies have documented that dietary fiber was inversely associated with a variety of diseases, but the association prognosis older adults hypertension is unknown. The aim to assess all-cause and cardiovascular mortality in hypertension.
We have previously found that sarcosine, a glycine transporter I inhibitor, can improve the psychiatric symptoms of schizophrenia. In this study, we aimed to investigate whether agent also ameliorate neuropsychiatric Parkinson's disease (PD) patients with dementia.An 8-week, double-blind, placebo-controlled trial was conducted in who had PD dementia (PD-D). Neuropsychiatric manifestations were measured before and at week 2 (V1), 4 (V2) 8 (V3) after treatment. Linear regression generalized...
β-Amyloid peptide (Abeta) was used to induce apoptosis in PC12 cells differentiated by nerve growth factor, and the protective activities of maslinic acid (MA) at 2-16 μM were examined. Abeta treatment lowered Bcl-2 expression, raised Bax decreased cell viability. MA pretreatments Bcl-2/Bax ratio, increased retained glutathione content subsequent Abeta-induced release reactive oxygen species, tumor necrosis factor-α, interleukin (IL)-1β, IL-6. up-regulated protein expression p47(phox),...
We adopt the existing Deep learning architecture to support diagnosing acute ischemic stroke by automatically detecting lesion location on 3D non-contrast CT brain scans. also investigate feasibility of model's applications in clinical scenario data analysis. retrospectively collected scans 317 patients with from China Medical University Hospital. All underwent standard baseline scanning followed diffusion-weighted imaging. utilized these for training model – SwinUNETR, which includes a...
The effects of oxybutynin, solifenacin and tolterodine on dementia risk in patients with diabetes mellitus (DM) remain unknown. We investigated the DM.We conducted a cohort study by using dataset Taiwan National Health Insurance Research Database from 1 January, 2002 to 31 December, 2013. included 10,938 received one type solifenacin, or tolterodine, while 564,733 had not. comparable number not receiving as controls through systematic random sampling matching age, gender, year index date...
Background and PurposeTo determine the risk of Parkinson's disease (PD) in relation to erectile dysfunction (ED) based on National Health Insurance Research Database Taiwan. MethodsWe identified 3,153 patients who were newly diagnosed with ED between January 1, 2004 December 31, 2010.A total 12,612 randomly selected people without served as healthy controls.All study subjects followed-up from index date PD diagnosis, withdrawal program, or end 2012 whichever occurred first. ResultsThe...
Background & Aims The association between Helicobacter pylori infection and end-stage renal disease (ESRD) events remains unknown. We assessed the relationship H. requiring hospital admission subsequent risks of ESRD. Methods This was a retrospective cohort study in which data from National Health Insurance system Taiwan used. pylori-infected comprised 20,068 patients. Each participant frequency-matched by age sex with 4 individuals general population without pylori-infected. Cox...
Objectives: The Clinical Dementia Rating (CDR) Scale is the gold standard for staging of dementia due to Alzheimer's disease (AD). However, application CDR subjective cognitive decline (SCD) and mild impairment (MCI) in AD remains controversial. This study aimed use sum boxes (CDR-SB) plus an SCD single questionnaire operationally determine different stages (CI) non-AD. Methods: was a two-phase study, we retrospectively analyzed Show Chwan registry database using data selected from 2015...
Archery exercise exerts a rehabilitative effect on patients with paraplegia and might potentially serve as complementary physiotherapy for Parkinson's disease. This study aimed to examine the effects of an archery intervention. A randomized controlled trial 12-week intervention was performed in idiopathic Thirty-one 39 eligible recruited from medical center Taiwan participated trial, whom 16 were experimental group practicing exercises 15 control at beginning; twenty-nine completed whole...
This nationwide population-based study investigated the risk of cardiovascular diseases after 5-alpha-reductase inhibitor therapy for benign prostate hyperplasia (BPH) using National Health Insurance Research Database (NHIRD) in Taiwan.In total, 1,486 adult patients newly diagnosed with BPH and who used inhibitors were recruited as cohort, along 9,995 subjects did not use a comparison cohort from 2003 to 2008. Each patient was monitored 5 years, those subsequently had identified. A Cox...
Pulse pressure (PP) is an independent predictor of cardiovascular and/or all-cause mortality in patients with underlying disease. We examined whether PP can be used to predict overall peritoneal dialysis (PD) patients.We studied 153 PD (mean age, 54.5 +/- 14.2 years) end-stage renal was measured monthly for 3 months. At the time third measurement, baseline demographic, clinical, biochemical, and data were collected. Patients stratified into tertiles according average PP, relationship between...
BACKGROUND This nationwide population‐based study investigated the risk of type 2 diabetes mellitus (DM) after 5‐alpha‐reductase inhibitor (5ARI) therapy for benign prostate hyperplasia (BPH) using National Health Insurance Research Database (NHIRD) in Taiwan. METHODS In total, 1,298 adult patients newly diagnosed with BPH and who used more than 28 cumulative defined daily doses (cDDD) 5ARI were recruited as group cohort, along 1,2887 subjects did not use cDDD a control from 2002 to 2009....
Parkinson's disease (PD) is a common progressive neurodegeneration disease. Its incidence increases with age and affects about 1% of people over 60. Incidentally, transient receptor potential V1 (TRPV1) its relation neuroinflammation in mouse brain has been widely reported.We used 6-hydroxydopamine (6-OHDA) to induce PDD mice. We then the Morris water maze Bio-Plex test learning inflammatory mediators plasma. Western blotting immunostaining were examine TRPV1 pathway hippocampus medial...
In clinical practice, hyponatraemia was frequently found in patients with hydrocephalus. We conducted this study to determine the prevalence and risk factors for normal pressure hydrocephalus (NPH).We retrospectively reviewed all NPH who were admitted China Medical University Hospital between 1998 2006. Hyponatraemia defined as a plasma sodium concentration < 135 mEq/l on admission. Possible without analysed using Student's t-test or chi2 test. The association possible multivariate logistic...
Abstract Patients with prostate cancer have an increased risk of stroke, but their absolute rate stroke depends on age and comorbid conditions. The Charlson Comorbidity Index Score ( CCIS ) is a widely accepted measure for adjustment in administrative claims data sets. This study assesses the predictive value CHADS 2 scores among patients cancer. was conducted based taken from Taiwan's National Health Insurance Research Database NHIRD ). We identified total 5414 participants nonatrial...
In the blast furnace, due to different changing frequency of operations, and reaction time gas, liquid solid materials, there exists multi-timescale characteristics in iron-making process. However, not enough attention has been paid this characteristic, most analyses on furnace state before are under a fixed scale. So, paper makes analysis influencing factors carbon monoxide utilization rate based characteristics. First, that affect analyzed from scales. Next, short scale, individual scale...