A5039252101- Migraine and Headache Studies
- Dementia and Cognitive Impairment Research
- Trigeminal Neuralgia and Treatments
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Neuropathies and Disorders
- Neuroscience of respiration and sleep
- Neurological Complications and Syndromes
- Stroke Rehabilitation and Recovery
- Ophthalmology and Eye Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Chemical synthesis and alkaloids
- Psychosomatic Disorders and Their Treatments
- IL-33, ST2, and ILC Pathways
- Psychedelics and Drug Studies
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Tryptophan and brain disorders
- Cerebral Venous Sinus Thrombosis
- Multiple Sclerosis Research Studies
- Orthopedic Surgery and Rehabilitation
National Defense Medical Center
2016-2025
Tri-Service General Hospital
2016-2025
Hunan Provincial People's Hospital
2024
National Cheng Kung University
2016-2021
Shanghai First People's Hospital
2021
National Taiwan University
2021
University of Alberta
2021
National Chin-Yi University of Technology
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
National Yang Ming University Hospital
2013-2018
The aim of this study was to conduct a comprehensive analysis the placement multiple wearable sensors for purpose analyzing and classifying gaits patients with neurological disorders. Seven inertial measurement unit (IMU) were placed at seven locations: lower back (L5) both sides thigh, distal tibia (shank), foot. 20 subjects selected participate in separated into two groups: stroke (11) disorders other than (brain concussion, spinal injury, or brain hemorrhage) (9). temporal parameters gait...
The risk of substance use disorder (SUD) in patients with autism spectrum (ASD) remains unclear.To investigate the SUD ASD and its associations comorbidities, psychotropic agents (PAs), mortality.This retrospective, population-based, cohort study 1 936 512 participants used data from Taiwan National Health Insurance Research Database was conducted January 1, 2000, to December 31, 2015. Included attended at least 3 outpatient visits within 1-year period for symptomatic as determined by...
Background ChatGPT may act as a research assistant to help organize the direction of thinking and summarize findings. However, few studies have examined quality, similarity (abstracts being similar original one), accuracy abstracts generated by when researchers provide full-text basic papers. Objective We aimed assess applicability an artificial intelligence (AI) model in generating for preclinical research. Methods selected 30 papers from Nature, Genome Biology, Biological Psychiatry....
Previous functional imaging studies in episodic cluster headache (CH) patients revealed altered brain metabolism concentrated on the central descending pain control system. However, it remains unclear whether changes during "in bout" period are due to structural and these vary between "out of periods. To quantify CH patients, regional gray matter volume (GMV) was compared among 49 age- sex-matched controls. Twelve were rescanned evaluate changes, if any, 2 Compared with healthy controls,...
Migraine has been associated with sleep disturbances. Relationship between quality and migraine frequency is yet to be determined. The present study aimed investigate disturbances among low-frequency, moderate-frequency, high-frequency, chronic migraineurs, without auras, well-controlled confounding variables. This cross-sectional controlled included 357 subjects from an outpatient headache clinic in Taiwan. Standardized questionnaires were utilized collect demographic, migraine, sleep,...
Background While migraines have been associated with emotional disturbances, it remains unknown whether the intensity of expression is directly related to migraine frequency. Objective The present study investigated depression/anxiety among migraineurs. Methods This cross‐sectional included 588 clinical outpatients in Taiwan. Migraines were stratified by attack frequency, and without auras, well‐controlled confounding variables. Demographic data, including sleep characteristics, collected....
Abstract Background Early rehabilitation has been shown to enhance functional outcomes. Whether the addition of virtual reality (VR) training could further improve muscle strength, mood state, and status for patients with acute stroke is unknown. Aims To investigate effectiveness VR on state (depression, anxiety), in following stroke. Methods A randomized controlled trial was conducted. Patients ischemic ( N = 152) were selected randomly assigned a 1:3 randomization ratio either experimental...
Purpose To investigate the performance of hematoma shape, size, Glasgow coma scale (GCS) score, and intracerebral (ICH) score in predicting 30-day mortality for ICH patients. examine influence estimation error size on prediction mortality. Materials Methods This retrospective study, approved by a local institutional review board with written informed consent waived, recruited 106 patients diagnosed as non-enhanced computed tomography study. The hemorrhagic measured computer-assisted...
<h3>Background</h3> Neuroimaging studies implicate hypothalamic dysfunction in the pathogenesis of cluster headache (CH). Disruptions non-traditional pain processing areas, including cerebellum and visual cortex, have also been reported CH. It is unknown whether hypothalamus interacts significantly with these any such interactions vary between 'in-bout' 'out-of-bout' periods This study aimed to investigate resting-state functional connectivity (FC) patients <h3>Methods</h3> Using 3-T MRI, we...
Abstract Background Several observational studies have identified a positive association between cancer survivors and subsequent dementia whereas others negative or no association. Aims & Objectives This study aimed to determine the in Taiwanese patients using large, community-based national claim data. Method Using Taiwan National Health Insurance Research Database, we recruited 32,250 surviving malignancies 322,500 controls 1998 2011 followed them up until end of 2013. A diagnosis...
Objective Whether elevation in plasma levels of amyloid and tau protein biomarkers are better indicators cognitive decline than higher baseline patients with amnestic mild impairment (aMCI) Alzheimer’s disease (AD) remains understudied.Methods We included 67 participants twice testing for AD-related via immunomagnetic reduction (IMR) assays (amyloid beta [Aβ]1-40, Aβ1-42, total [t-Tau], phosphorylated [p-Tau] 181, alpha-synuclein [α-Syn]) the Mini-Mental State Examination (MMSE) over a...
Vitamin B12 deficiency causes skin hyperpigmentation, subacute combined degeneration of the spinal cord, and megaloblastic anemia. Although vitamin rarely occurs in well-nourished, healthy, young people, nitrous oxide (N2O) intoxication is an important cause this cohort. N2O, a colorless gas used as anesthetic since late 19th century because its euphoric analgesic qualities, now recreational drug available via Internet at clubs. Here, we describe case 29-year-old woman presenting with...
The number of old adults with cognitive impairment or dementia is anticipated to increase rapidly due the aging population, especially patients multiple chronic conditions metabolic perturbation. Metabolic syndrome (Mets) among most hazardous risk factors for cardiovascular disease and linked a inflammatory disease. We investigated National Health Nutrition Examination Survey (NHANES) database years 1999 2002 explore connection between Mets decline. A total 2252 NHANES (1999–2002)-registered...
Brain degeneration in patients with Alzheimer's disease (AD) results from the accumulation of pathological amyloid- (Aβ) plaques and tau protein tangles, leading to altered plasma levels biomarkers. However, few studies have investigated association between biomarkers cognitive impairment AD. In this cross-sectional study, we correlations mini-mental state examination (MMSE) scores amnestic mild (aMCI) Thirteen individuals normal cognition, 40 aMCI, 37 AD were enrolled. Immunomagnetic...
Abstract Background The neuroprotective role of interleukin (IL)-33 is supported by numerous preclinical studies, but it remains uninvestigated in clinical studies Alzheimer’s disease (AD). We aimed to examine the association between human blood levels IL-33 and cognitive preservation amnestic mild impairment (aMCI) AD. Methods A total 100 participants (26 controls, 35 aMCI patients, 39 AD patients) completed two Mini-Mental State Examinations (MMSEs) over a 1-year interval. In all at second...