Background While migraines have been associated with emotional disturbances, it remains unknown whether the intensity of expression is directly related to migraine frequency. Objective The present study investigated depression/anxiety among migraineurs. Methods This cross‐sectional included 588 clinical outpatients in Taiwan. Migraines were stratified by attack frequency, and without auras, well‐controlled confounding variables. Demographic data, including sleep characteristics, collected....

Aims: Obstructive sleep apnea (OSA) and insomnia commonly coexist; hypnotics are broadly prescribed for therapy. However, the safety of use in OSA patients is unclear. We conducted a retrospective case-control study to investigate risk adverse respiratory events hypnotics-using patients. Methods: obtained data from Taiwan National Health Insurance Database 1996 2013. The case group included 216 with newly diagnosed events, including pneumonia acute failure. control without which was randomly...

Abstract Background The neuroprotective role of interleukin (IL)-33 is supported by numerous preclinical studies, but it remains uninvestigated in clinical studies Alzheimer’s disease (AD). We aimed to examine the association between human blood levels IL-33 and cognitive preservation amnestic mild impairment (aMCI) AD. Methods A total 100 participants (26 controls, 35 aMCI patients, 39 AD patients) completed two Mini-Mental State Examinations (MMSEs) over a 1-year interval. In all at second...

Brain degeneration in patients with Alzheimer's disease (AD) results from the accumulation of pathological amyloid- (Aβ) plaques and tau protein tangles, leading to altered plasma levels biomarkers. However, few studies have investigated association between biomarkers cognitive impairment AD. In this cross-sectional study, we correlations mini-mental state examination (MMSE) scores amnestic mild (aMCI) Thirteen individuals normal cognition, 40 aMCI, 37 AD were enrolled. Immunomagnetic...

Background: Migraines with aura have been associated suicide in adolescents and young adults, but the association between migraine frequency has not determined. This study investigated suicidal ideation attempts among patients varying frequencies of migraines, without auras. Methods: cross-sectional analyzed 528 aged 20 60 years from a headache outpatient clinic Taiwan. All completed set questionnaires, including demographic questionnaire, Migraine Disability Assessment Hospital Anxiety...

Introduction The relationships between family history, sex, age at onset, and migraine occurrence have been documented. However, the associations these factors across different sexes subgroups of patients yet to be elucidated. This study evaluated association history in male female experiencing episodic chronic with without aura. Methods cross-sectional, case–control included 299 headache-free controls 885 receiving outpatient treatment for migraine. Participants were classified into (1–14...

The rate of cognitive decline among patients with amnestic mild impairment (aMCI) varies, and it is thus crucial to accurately predict the probability deterioration in MCI. We compared potential cytokines amyloid beta (Aβ) tau biomarkers for predicting aMCI or Alzheimer’s disease (AD). All participants (controls, aMCI, AD patients) underwent plasma biomarker examinations Aβ 1–40 , 1–42 total (t-tau), phosphorylated at threonine 181 [ p -Tau181]), 29 baseline tests, including Mini-Mental...

Objectives Subjective cognitive complaints by patients with migraine have been associated memory impairment. However, whether the severity of impairment relates to characteristics, such as attack frequency and aura, remains undetermined. We investigated relationship between subjective characteristics. Materials methods This cross-sectional study recruited 669 clinic outpatients from Taiwan. stratified them presence or absence we controlled data for confounding variables. performed...

Objective Since the inflammatory process has been implicated in pathophysiology of psychiatric disorder, an important issue emerging is to assess test-retest reliability cytokine measurement healthy individuals and patients with schizophrenia. The objective present study was investigate bead-based multiplex immunoassay technology (BMIT) for by using a Bland-Altman plot (BAP). Methods Twenty twenty schizophrenia were enrolled, 17-plex assay used measure biomarkers at baseline two weeks later....

Objective: A certain portion of patients with depression is under-diagnosed and has attracted the attention in field natural language processing (NLP). In this study, we intended to explore feasibility transferring unstructured textual records into a screening tool early detect depression. Methods: We recruited 22,355 medical Mandarin traditional Chinese from psychiatry emergency department military center 2004 2019. preprocessed all context present illness histories as corpus presence...

Background: The association of treatment resistance with physical and psychiatric comorbidities remains unclear in elderly patients late-onset major depressive disorder (MDD).Methods: Participants were selected from the Taiwan National Health Insurance Research Database. We included aged ≥ 65 years first-episode MDD (ICD-9-CM codes: 296.2X 296.3X) between January 1, 2001, December 31, 2010. All participants followed for 1 year to investigate incidence resistance. Treatment-resistant...

Background: Brain degeneration in patients with Alzheimer's disease (AD) results from the accumulation of pathological amyloid β plaques and Tau protein tangles, leading to altered plasma levels biomarkers. However, few studies have investigated association between biomarkers cognitive impairment AD.Methods: In this cross-sectional study, we correlations Mini-Mental State Examination (MMSE) scores amnestic mild (aMCI) AD. Thirteen individuals normal cognition, 40 aMCI, 37 AD were enrolled....

Schizophrenia has been associated with dysfunction of the hypothalamic-pituitary-adrenal axis. Furthermore, alterations in neurotrophic factors might contribute to pathogenesis schizophrenia. We aimed evaluate effects a simulated laughter intervention on levels cortisol and BDNF determine whether could be sustained after discontinuation intervention.In this randomized controlled study, patients schizophrenia according DSM-IV clinical criteria were randomly assigned receive either 8-week-long...

Background: Experimental and clinical studies have reported increased levels of pro-inflammatory cytokines in patients with major depressive disorder (MDD), suggesting that immune system dysregulation may contribute to MDD pathophysiology. Aim: Due the lack knowledge about potential antidepressants, this study investigated immunomodulatory effects bupropion, a norepinephrine–dopamine reuptake inhibitor. Methods: This involved 18 treated bupropion (150 mg/d) for 4 weeks 23 healthy volunteers....

Abstract Background: The neuroprotective role of Interleukin (IL)-33 is supported in numerous pre-clinical studies but remains mostly uninvestigated clinical Alzheimer’s disease (AD). We aimed to examine the association between human blood levels IL-33 and cognitive preservation amnestic mild impairment (aMCI) AD. Methods: A total 100 participants (26 controls, 35 aMCI patients, 39 AD patients) were completed twice Mini Mental State Examination (MMSE) over a 1-year interval. At second MMSE,...

Objective: The neuroprotective role of Interleukin (IL)-33 is supported in numerous pre-clinical studies but remains mostly uninvestigated clinical Alzheimer’s disease (AD). We aimed to examine the association between human blood levels IL-33 and cognitive preservation amnestic mild impairment (aMCI) AD. Methods: A total 100 participants (26 controls, 35 aMCI patients, 39 AD patients) were completed twice Mini Mental State Examination (MMSE) over a 1-year interval. At second MMSE, examined...

Abstract Background: The neuroprotective role of interleukin (IL)-33 is supported by numerous pre-clinical studies, but it remains uninvestigated in clinical studies Alzheimer’s disease (AD). We aimed to examine the association between human blood levels IL-33 and cognitive preservation amnestic mild impairment (aMCI) AD. Methods: A total 100 participants (26 controls, 35 aMCI patients, 39 AD patients) completed two Mini Mental State Examination (MMSE) over a 1-year interval. In all at...

Abstract Background: The neuroprotective role of Interleukin (IL)-33 is supported in numerous pre-clinical studies but remains mostly uninvestigated clinical Alzheimer’s disease (AD). We aimed to examine the association between human blood levels IL-33 and cognitive preservation amnestic mild impairment (aMCI) AD. Methods: A total 100 participants (26 controls, 35 aMCI patients, 39 AD patients) were completed twice Mini Mental State Examination (MMSE) over a 1-year interval. At second MMSE,...