Ching‐Huang Lin
A5000795102- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Dementia and Cognitive Impairment Research
- Congenital Heart Disease Studies
- Heavy Metal Exposure and Toxicity
- Ultrasound in Clinical Applications
- Heavy metals in environment
- Dialysis and Renal Disease Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Sirtuins and Resveratrol in Medicine
- Chronic Kidney Disease and Diabetes
- Trace Elements in Health
- Heart Rate Variability and Autonomic Control
- Mercury impact and mitigation studies
- Cardiovascular Syncope and Autonomic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal and Vascular Pathologies
- Transcranial Magnetic Stimulation Studies
- Voice and Speech Disorders
- Advanced Bandit Algorithms Research
- Dysphagia Assessment and Management
- Stuttering Research and Treatment
Kaohsiung Veterans General Hospital
2015-2025
National Taipei University of Technology
2024
National Sun Yat-sen University
2017-2022
Ministry of Science
2022
Taipei Veterans General Hospital
2019
Min-Hwei College of Health Care Management
2017-2019
Taipei Tzu Chi Hospital
2017
National Yang Ming Chiao Tung University
2012
National Yang Ming University Hospital
2012
National Cheng Kung University
2010
The time to initiate intravenous thrombolysis for acute ischemic stroke is generally limited within 4.5 hours after the onset of symptoms. Some trials have suggested that treatment window may be extended in patients who are shown but not yet infarcted brain tissue on imaging.
Recent studies have indicated that several anti-hypertensive drugs may delay the development and progression of Alzheimer's disease (AD). However, relationships among AD, hypertension, oxidative stress remain to be elucidated. Here, we aimed determine whether reactive oxygen species (ROS) reduction by resveratrol in brain leads cognitive impairment rats with angiotensin II (Ang-II)-induced early AD. Male Wistar Kyoto (WKY) Ang-II-induced AD were treated losartan or for two weeks. Our results...
Background and Purpose: As populations age, there is an increasing need to optimize endovascular treatment (EVT) for acute ischemic stroke. We harmonized prospective stroke registries from Korea Taiwan enable direct comparisons of patient characteristics clinical outcomes, with a particular focus on the impact advanced age. Methods: Prospective in South (CRCS-K) (TREAT-AIS) were form unified dataset patients treated EVT. EVT outcomes included 3-month modified Rankin Scale (mRS), symptomatic...
Symptomatic intracranial hemorrhage (sICH) following endovascular thrombectomy (EVT) is a severe complication associated with adverse functional outcomes and increased mortality rates. Currently, reliable predictive model for sICH risk after EVT lacking. This study used data from patients aged ≥20 years who underwent anterior circulation stroke the nationwide Taiwan Registry of Endovascular Thrombectomy Acute Ischemic Stroke (TREAT-AIS). A including factors an was developed to differentiate...
Few studies have examined the relationship between amounts of heavy metal and stroke incidence. The aim this study was to explore levels metals, including Pb, Hg, As, Cd, in patients with acute ischemic (AIS). We selected first-ever AIS onset within 1 week as our group. Healthy controls were participants without a history or chronic disease, except hypertension. serum Cd experimental control groups determined. All received 1-g infusion edetate calcium disodium (EDTA). Urine specimens...
The relationship between cholesterol level and hemorrhagic stroke is inconclusive. We hypothesized that low levels may have association with intracerebral hemorrhage (ICH) severity at admission 3-month outcomes. This study used data obtained from a multi-center registry program in Taiwan. categorized acute spontaneous ICH patients, based on their baseline of total (TC) measured admission, into 3 groups <160, 160-200 >200 mg/dL TC. evaluated risk having initial severity, National Institutes...
Background Clopidogrel was thought to be superior aspirin for secondary prevention of vascular diseases in clinical trials. In this study we assessed the safety and efficacy clopidogrel versus real‐world practice by using Taiwan Stroke Registry. Methods Results Patients with ischemic stroke (2006–2016) on or were identified recurrence mortality rates patients receiving (N=34 679) compared those (N=7611) during a 12‐month follow‐up period. Propensity score matching conditional Cox...
Background and Purpose- The observation that smokers with stroke could have better outcome than nonsmokers led to the term "smoking paradox." controversy of such a complex claim has not been fully settled, even though different case mix was noted. Analyses were conducted on 2 independent data sets evaluate determine whether paradox truly exists. Methods- Taiwan Stroke Registry 88 925 cases, MJ cohort 541 047 adults participating in medical screening program 1630 deaths developed during 15...
Cerebrovascular disease is the second commonest cause of mortality globally and among causes disability. However, research executed to probe heavy metal exposure-stroke incidence relationship scarce. Accordingly, we our study concentrations (ie, lead [Pb], mercury [Hg], cadmium [Cd], arsenic) in serum urine acute ischemic stroke (AIS) patients with several patient variables.For enrollment, chose who had a first AIS within 7 days after onset stroke. Thus, 33 newly diagnosed were recruited. We...
Pulse pressure (PP) is related to cardiac function, arterial stiffness, fluid status, and vascular events. This study aimed explore the prognostic role of PP upon admission in patients with acute ischemic stroke (AIS) based on a nation-wide registry.We evaluated association between outcomes 3 months after who had an AIS registered Taiwan Stroke Registry, including 56 academic community hospitals 2006 2013. Three stroke, unfavorable were defined using modified Rankin scale 6. Of 33 530...
Autonomic dysfunctions including impaired baroreflex sensitivity (BRS) can develop after acute ischemic stroke (AIS) and may predispose patients to subsequent cardiovascular adverse events serve as potential indicators of long-term mortality. This study aimed determine the short-term prognostic significance BRS AIS. All admitted Kaohsiung Veterans General Hospital within 72 h onset first-ever AIS between April 2008 December 2012 were enrolled. evaluation with continuous 10-minute monitoring...
Background Motor recovery following a stroke is related to the initial severity and corticospinal tract integrity. One of outcomes representing integrity motor evoked potential (MEP). This study aimed investigate predictive value MEP for in patients with acute ischemic stroke.Patients Methods Patients hemiparesis secondary were enrolled. MEPs upper limb assessed as preserved (MEP+) or absent (MEP-) response ≤10 days post-stroke. Fugl-Meyer assessment (FMA) was performed at baseline...
Hyperglycemia affects the outcomes of endovascular therapy (EVT) for acute ischemic stroke (AIS). This study compares predictive ability diabetes status and glucose measures on EVT using nationwide registry data.
In this large-scale prospective cohort study, a propensity score matching method was applied in natural experimental design to investigate how post-acute care (PAC) after stroke affects functional status and identify predictors of status. The main objective study examine longitudinal changes various measures patients scores for these before PAC. A group who had received PAC at one two medical centers (PAC group, n = 273) compared with standard four hospitals (three regional hospital district...
Background Machine learning algorithms for predicting 30-day stroke readmission are rarely discussed. The aims of this study were to identify significant predictors after and compare prediction accuracy area under the receiver operating characteristic (AUROC) curve in five models: artificial neural network (ANN), K nearest neighbor (KNN), random forest (RF), support vector machine (SVM), naive Bayes classifier (NBC), Cox regression (COX) models. Methods subjects prospective cohort 1,476...
Recent studies have indicated that several anti-hypertensive drugs may delay the development and progression of Alzheimer&rsquo;s disease (AD). However, relationships among AD, hypertension, oxidative stress remain to be elucidated. In present study, we aimed determine whether treatment with resveratrol reduces reactive oxygen species (ROS) generation in brain, thereby reducing cognitive impairment rats angiotensin II (Ang-II)-induced early AD. Male WKY Ang-II-induced AD were treated...
Background Endovascular thrombectomy (EVT) is the standard therapy for patients with acute ischemic stroke secondary to large‐artery occlusion. In January 2019, Taiwan Stroke Society established a nationwide TREAT‐AIS (Taiwan Registry of Thrombectomy Acute Ischemic Stroke). Here, we provide study design, current progress, and baseline data TREAT‐AIS. Methods multicenter prospective registration program in Taiwan. Patients aged ≥20 years who underwent EVT were recruited. The key items on form...
Few studies have compared the optimal duration and intensity of organized multidisciplinary neurological/rehabilitative care delivered in a regional/district hospital with standard rehabilitative general neurology/rehabilitation ward medical center. This study measured functional outcomes conducted cost-utility analysis an postacute (PAC) project secondary tertiary care.This prospective cohort enrolled 1,476 patients who had stroke between March 2014 2018 modified Rankin scale score 2-4....
Abstract Background No studies have discussed machine learning algorithms to predict the risk of 30-day readmission in patients with stroke. The objective present study was compare accuracy artificial neural network (ANN), K nearest neighbor (KNN), support vector (SVM), naive Bayes classifier (NBC), and Cox regression (COX) models explore significant factors predicting after Methods This prospectively compared using clinical data for 1,476 stroke treated six hospitals between March, 2014...