A5101665825- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Atrial Fibrillation Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Functional Brain Connectivity Studies
- Moyamoya disease diagnosis and treatment
- Dialysis and Renal Disease Management
- Peripheral Artery Disease Management
- Phagocytosis and Immune Regulation
- Insect Utilization and Effects
- Cancer Research and Treatments
- Transcranial Magnetic Stimulation Studies
- Cerebrovascular and genetic disorders
- Insect and Arachnid Ecology and Behavior
- Vestibular and auditory disorders
- Vascular Malformations Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Vascular Procedures and Complications
- Heart Failure Treatment and Management
Taipei Veterans General Hospital
2015-2025
National Yang Ming Chiao Tung University
2013-2024
National Institute of Diabetes and Digestive and Kidney Diseases
2019
ProQuest (United States)
2019
Bioengineering Center
2019
Taipei Institute of Pathology
2017
Taipei Tzu Chi Hospital
2017
National Yang Ming University Hospital
2014-2017
The University of Texas MD Anderson Cancer Center
2016
Jen-Ai Hospital
2014
Use of low-dose aspirin for the primary prevention cardiovascular events remains controversial because increased risk bleeding may offset overall benefit. Among major events, intracranial hemorrhage is associated with high mortality rates and functional dependency.To assess among individuals without symptomatic disease.PubMed, Embase, Cochrane Central Register Controlled Trials, ClinicalTrials.gov were searched from January 1966 to October 30, 2018.Randomized clinical trials that compared...
Background and Purpose: As populations age, there is an increasing need to optimize endovascular treatment (EVT) for acute ischemic stroke. We harmonized prospective stroke registries from Korea Taiwan enable direct comparisons of patient characteristics clinical outcomes, with a particular focus on the impact advanced age. Methods: Prospective in South (CRCS-K) (TREAT-AIS) were form unified dataset patients treated EVT. EVT outcomes included 3-month modified Rankin Scale (mRS), symptomatic...
Symptomatic intracranial hemorrhage (sICH) following endovascular thrombectomy (EVT) is a severe complication associated with adverse functional outcomes and increased mortality rates. Currently, reliable predictive model for sICH risk after EVT lacking. This study used data from patients aged ≥20 years who underwent anterior circulation stroke the nationwide Taiwan Registry of Endovascular Thrombectomy Acute Ischemic Stroke (TREAT-AIS). A including factors an was developed to differentiate...
Severe asymptomatic stenosis of the internal carotid artery (ICA) leads to increased incidence mild cognitive impairment (MCI) likely through silent embolic infarcts and/or chronic hypoperfusion, but brain dysfunction is poorly understood and difficult diagnose. Thirty cognitively intact subjects with asymptomatic, severe (≥ 70%), unilateral ICA were compared 30 healthy controls, matched for age, sex, cardiovascular risk factors education level, on a battery neuropsychiatric tests,...
Young stroke incidence has increased worldwide with lifestyle changes. Etiology and risk factors for both ischemic hemorrhagic in young Asians remain underexplored.We retrospectively reviewed consecutive acute patients aged 16-45 years admitted to the Taipei Veterans General Hospital between 2009 2019 analyze etiologic subtypes, factors, serial modified Rankin Scale scores 1 year compare age groups of 16-30 31-45 years.Among 670 Taiwanese (mean at onset 37.5 ± 7.0 years; male 65.1%), there...
Abstract Background Dual transcranial direct current stimulation (tDCS) to the bilateral primary motor cortices (M1s) has potential benefits in chronic stroke, but its effects subacute when behavioural might be expected greater, have been relatively unexplored. Here, we examined neurophysiological and factors influencing responsiveness of dual-tDCS stroke survivors. Methods We conducted a randomized sham-controlled crossover study 18 survivors with first-ever, unilateral subcortical...
Hyperperfusion syndrome is a devastating complication of carotid stent placement. The shortening cerebral circulation time after placement seen as good indicator the development hyperperfusion syndrome. purpose our study was to evaluate whether patients with ipsilateral transverse sinus stenosis are prone having shortened placement, subsequently leading possible syndrome.Forty-nine >70% unilateral undergoing were recruited for analysis. Group A consisted stenotic >50% greater than diameter...
<h3>BACKGROUND AND PURPOSE:</h3> Asymptomatic carotid stenosis of ≥70% increases the incidence microembolism and/or chronic hypoperfusion, which may consequently impair neurocognition and brain connections. We sought controlled evidence for any cognitive benefit aggressive medical therapy combined revascularization. <h3>MATERIALS METHODS:</h3> Patients with asymptomatic, unilateral, ≧70% extracranial ICA chose either alone or in combination artery stent placement this nonrandomized study....
Current practice of revascularization for carotid stenosis (CS) primarily relies on symptoms and degree stenosis. Other parameters, such as collateral circulation cerebral time (CCT), might influence the stroke risk in CS. This study was conducted to (1) investigate whether CCT is more associated with symptomatic CS than (2) elucidate associations among stenosis, status, CCT.From 2010 2016, 82 patients unilateral were enrolled DSA divided into asymptomatic groups based clinical presentation....
Severe carotid stenosis is associated with cognitive impairment, which may be attributed to asymptomatic microembolism and/or chronic hypoperfusion. We aim evaluate the long-term and brain connectivity outcomes of artery stenting (CAS) for ≥70% extracranial internal (ICA). conducted a non-randomized controlled study compare intensive medical therapy alone (Med) or in combination composite vascular events, neuropsychological, multimodal magnetic resonance perfusion imaging diffusion tensor...
Hyperglycemia affects the outcomes of endovascular therapy (EVT) for acute ischemic stroke (AIS). This study compares predictive ability diabetes status and glucose measures on EVT using nationwide registry data.
Verbal memory decline is a common complaint of patients with severe asymptomatic stenosis the internal carotid artery (aICS). Previous publications explored associations between verbal and altered functional connectivity (FC) after aICS. Patients aICS may show reduced perfusion in ipsilateral territory redistribution cerebral blood flow to compensate for deficient regions, including expansion posterior contralateral ICA territories via circle Willis. However, aICS-related FC changes anterior...
<h3>BACKGROUND AND PURPOSE:</h3> From the time-attenuation curves of DSA flow parameters, maximal intensity, slope, and full width at half maximum selected vascular points are defined. The study explores reliability defining parameters by DSA. <h3>MATERIALS METHODS:</h3> Seventy patients with unilateral carotid artery stenosis (group A) 56 healthy controls B) were retrospectively enrolled. Fixed contrast injection protocols acquisition used all patients. M1, sigmoid sinus, internal jugular...
Background and Purpose: Recent non-inferiority clinical trials of novel endovascular thrombectomy devices for acute ischemic stroke have used the primary outcome achievement substantial reperfusion. Determining minimal clinically important difference (MCID) is an essential step design trials. Methods: We surveyed international neuro-interventionalist non-interventional vascular neurologist investigators. The questionnaire included demographic characteristics, level experience, their MCID...
Intracranial atherosclerotic disease (ICAD) is a major cause of ischemic stroke, especially in Asian populations, which has high risk recurrent stroke and cardiovascular comorbidities. The present guidelines aim to provide updated evidence-based recommendations for diagnosis management patients with ICAD. Taiwan Stroke Society guideline consensus group developed ICAD via meetings based on evidences. Each proposed class recommendation level evidence was approved by all members the group....
Background: Since the publication of 2015 Taiwan Stroke Society Blood Pressure for Treatment and Prevention Guideline (2015 TSS BP Guideline), several new clinical studies have addressed whether a stricter blood pressure (BP) target would be effective stroke prevention. Methods: guideline consensus group provides recommendations on targets prevention based updated evidences. Results: The present covers five topics: (1) diagnosis hypertension; (2) control primary ischemic stroke; (3)...
Current pieces of evidence support the short-term use dual antiplatelet (DAPT) in minor ischemic stroke or transient attack (TIA) based on studies performed patients with a broad range non-cardioembolic mechanisms. However, efficacy and safety DAPT large artery atherosclerosis (LAA) are still uncertain. We undertook systemic search formal meta-analysis to compare vs. mono-antiplatelet therapy (MAPT) etiology specifically presumed be symptomatic LAA.We conducted online for completed...
Whole exome sequencing (WES) has been used to detect rare causative variants in neurological diseases. However, the efficacy of WES genetic diagnosis clinically heterogeneous familial stroke remains inconclusive. We prospectively searched for disease-causing unrelated probands with defined by candidate gene/hotspot screening and/or WES, depending on subtypes and neuroimaging features at a referral center. The clinical significance each variant was determined according American College...
Background Endovascular thrombectomy (EVT) is the standard therapy for patients with acute ischemic stroke secondary to large‐artery occlusion. In January 2019, Taiwan Stroke Society established a nationwide TREAT‐AIS (Taiwan Registry of Thrombectomy Acute Ischemic Stroke). Here, we provide study design, current progress, and baseline data TREAT‐AIS. Methods multicenter prospective registration program in Taiwan. Patients aged ≥20 years who underwent EVT were recruited. The key items on form...
Arterial collateral (AC) assessed by single-phase computed tomography angiography (CTA) or multiphase CTA has been used to predict clinical outcomes in patients undergoing mechanical thrombectomy (MT). Recently, venous opacification (VO) was proposed as another accurate image marker. This study aimed compare the efficacy using AC and VO predictors of MT outcome.Patients with occlusion proximal anterior circulation were included retrospectively. We status respectively according different...
Timely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. Currently, it is unknown whether a low-dose thrombolytic agent (0.6 mg/kg alteplase) can offer similar efficacy to dose (0.9 alteplase).
Previous studies have reported that patients with asymptomatic internal carotid stenosis (aICS) had recall verbal memory impairment. However, the underlying mechanism to elucidate altered functional connectivity (FC) associated anterior and posterior circulation was not proposed. Furthermore, whether laterality of aICS is a factor in FC alterations impairment requires further investigation. In this study, we left right groups showed different patterns changes related secondary language...
Patients with atrial fibrillation (AF) are prescribed oral anticoagulants for stroke prevention; however, no evidence indicates that the use of direct (DOACs) in first few days after ischemic (IS) would result favorable outcomes. This study evaluated association between timing using DOACs IS and their effectiveness safety to determine optimal timing.In this retrospective cohort study, we reviewed electronic medical records Taipei Veterans General Hospital. The 1-year outcomes patients DOAC...