A5100672063- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Tryptophan and brain disorders
- Spinal Cord Injury Research
- Landslides and related hazards
- Toxic Organic Pollutants Impact
- Electrohydrodynamics and Fluid Dynamics
- Nerve injury and regeneration
- Cardiac Ischemia and Reperfusion
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Multiple Myeloma Research and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Immune Response and Inflammation
- Hearing Loss and Rehabilitation
- Bone Tissue Engineering Materials
- Effects and risks of endocrine disrupting chemicals
- Mass Spectrometry Techniques and Applications
- Cancer-related Molecular Pathways
- Curcumin's Biomedical Applications
- Attention Deficit Hyperactivity Disorder
- Cancer, Stress, Anesthesia, and Immune Response
- Heart Rate Variability and Autonomic Control
- Biochemical effects in animals
National Yang Ming Chiao Tung University
2014-2025
Nanjing Drum Tower Hospital
2022-2024
China Medical University
2009-2024
Nanjing Medical University
2024
National Central University
2024
National Tsing Hua University
2012-2023
University of East Anglia
2021-2023
National Taipei University of Technology
2023
Norwich Research Park
2023
Czech Academy of Sciences, Institute of Physiology
2008-2022
The antimicrobial activity of ZnO nanoparticles (NPs) was investigated under aquatic and aerosol exposure modes. NPs in media aggregated to micrometer-sized particles did not interact with microorganisms effectively. Hence, the inhibition microbial growth by nano-ZnO (e.g., Mycobacterium smegmatis Cyanothece 51142) mainly attributable dissolved zinc species. Shewanella oneidensis MR-1 Escherichia coli were able produce large amounts extracellular polymeric substances, their inhibited media,...
Growth-associated protein 43 (GAP43), a kinase C (PKC)-activated phosphoprotein, is often implicated in axonal plasticity and regeneration. In this study, we found that GAP43 can be induced by the endotoxin lipopolysaccharide (LPS) rat brain astrocytes both vivo vitro. The LPS-induced astrocytic expression was mediated Toll-like receptor 4 nuclear factor-κB (NF-κB)- interleukin-6/signal transducer activator of transcription 3 (STAT3)-dependent transcriptional activation. overexpression PKC...
The aryl hydrocarbon receptor (AhR) regulates peripheral immunity; but its role in microglia‐mediated neuroinflammation the brain remains unknown. Here, we demonstrate that AhR mediates both anti‐inflammatory and proinflammatory effects lipopolysaccharide (LPS)‐activated microglia. Activation of by ligands, formylindolo[3,2‐b]carbazole (FICZ) or 3‐methylcholanthrene (3MC), attenuated LPS‐induced microglial immune responses. also showed effects, as evidenced findings genetic silence...
// Kao-Hui Liu 1 , Shun-Tai Yang 2 Yen-Kuang Lin 3 Jia-Wei Yi-Hsuan Lee 4 Jia-Yi Wang 1,5 Chaur-Jong Hu 6 En-Yuan 7 Shu-Mei Chen 8 Chee-Kin Then 9 and Shing-Chuan Shen Taipei Medical University, College of Medicine, Graduate Institute Sciences, Taipei, Taiwan University-Shuang Ho Hospital, Department Neurosurgery, Biostatistics Center, National Yang-Ming Physiology, 5 School Neurology, University University-Wan Fang Correspondence: Shen, email: Keywords : glioblastoma, antidepressant, AMPA...
Intrauterine infection (chorioamnionitis) aggravates neonatal hypoxic–ischemic (HI) brain injury, but the mechanisms linking systemic inflammation to CNS damage remain uncertain. Here we report evidence for influx of T-helper 17 (T H 17)-like lymphocytes coordinate neuroinflammatory responses in lipopolysaccharide (LPS)-sensitized HI injury neonates. We found that both infants with histological chorioamnionitis and rat pups challenged by LPS/HI have elevated expression interleukin-23 (IL-23)...
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor activated by environmental agonists and dietary tryptophan metabolites for the immune response cell cycle regulation. Emerging evidence suggests that AHR activation after acute stroke may play role in brain ischemic injury. However, whether alters poststroke astrogliosis neurogenesis remains unknown.We adopted conditional knockout of from nestin-expressing neural stem/progenitor cells (AHRcKO) wild-type (WT) mice...
Purpose To investigate the neuroprotective effects of low-intensity pulsed (LIP) ultrasound on memory impairment and central nervous system injury in a rat model vascular dementia. Materials Methods All animal experiments were approved by care use committee adhered to experimental guidelines. A 1.0-MHz focused transducer was used stimulate brain noninvasively with 50-msec bursts at 5% duty cycle, repetition frequency 1 Hz, spatial peak temporal average intensity 528 mW/cm2. LIP treatment...
Increasing evidence suggests that elderly people with dementia are vulnerable to the development of severe coronavirus disease 2019 (COVID-19). In Alzheimer’s (AD), major form dementia, β-amyloid (Aβ) levels in blood increased; however, impact elevated Aβ on progression COVID-19 remains largely unknown. Here, our findings demonstrate Aβ1-42, but not Aβ1-40, bound various viral proteins a preferentially high affinity for spike protein S1 subunit (S1) acute respiratory syndrome 2 (SARS-CoV-2)...
This study investigates an optimized uniformity of Al-doped HfO2 resistive random access memory (RRAM) device. The RRAM devices in this exhibit excellent and stable switching behavior. is due to the formation Hf-O-Al bonding reduce oxygen vacancy energy. An Arrhenius plot shows that difference activation energy caused by doping effects can be attributed a Fermi level shift, which turn decreases resistance high state. temperature-dependent retention test makes it possible predict data storage...
Telomerase is highly expressed in cancer and embryonic stem cells (ESCs) implicated controlling genome integrity, formation stemness. Previous studies identified that Krüppel-like transcription factor 4 (KLF4) activates telomerase reverse transcriptase (TERT) expression contributes to the maintenance of self-renewal ESCs. However, little known about how KLF4 regulates TERT expression. Here, we discover poly(ADP-ribose) polymerase 1 (PARP1) as a novel KLF4-interacting partner. Knockdown PARP1...
Abstract Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates cell immune responses in type-specific and ligand-dependent manner. In the central nervous system, astrocytic AhR plays important roles regulating neuroinflammation by mediating to endogenous ligands generated from inflammation-induced indoleamine 2,3-dioxygenase 1 (IDO1)/kynurenine (KYN) pathway. We previously demonstrated reduction of expression decreases lipopolysaccharide (LPS)-induced...
Abstract We previously reported that 3‐methylcholanthrene (3MC), an aryl‐hydrocarbon receptor (AhR) agonist, inhibits the proliferation of human umbilical vascular endothelial cells (HUVECs; Juan et al., 2006, Eur J Pharmacol 530: 1–8). Herein, pretreatment HUVECs with p21 or p27 small interfering (si)RNA reduced 3MC‐induced elimination [ 3 H]thymidine incorporation, demonstrating their essential roles in antiproliferation HUVECs. The molecular mechanisms and involved antiproliferative...
Abstract The aryl hydrocarbon receptor (AhR) is a ligand‐activated transcription factor activated by dioxin and polyaromatic hydrocarbons. Recent studies have revealed that AhR activity in central neurons depends on the NMDA receptor. In this study, we investigated how neuronal influence AhR‐mediated dioxin‐responsive gene expression neurotoxicity. Our results show activation of selective agonist 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin induced calcium entry, which were attenuated small...
Curcumin has been proposed for treatment of various neuroinflammatory and neurodegenerative conditions, including post-traumatic inflammation during acute spinal cord injury (SCI). In this study, we examined whether curcumin anti-inflammation involves regulation astrocyte reactivation, with special focus on the injury-induced RANTES (regulated expression normal T-cell expressed secreted) from astrocytes in SCI. Male Sprague-Dawley (SD) rats were subjected to impact followed by (40 mg/kg...
Inflammation is a potential risk factor of mental disturbance. FKBP5 that encodes FK506-binding protein 51 (FKBP51), negative cochaperone glucocorticoid receptor (GR), stress-inducible gene and has been linked to psychiatric disorders. Yet, the role FKBP51 in inflammatory stress-associated disturbance remained unclear.Fkbp5-deficient (Fkbp5-KO) mice were used study stress by single intraperitoneal injection lipopolysaccharide (LPS). The anxiety-like behaviors, neuroimaging,...
Abstract Magnolol has been reported to have anticancer activity. In this study we found that treatment with 100 μm magnolol induced apoptosis in cultured human hepatoma (Hep G2) and colon cancer (COLO 205) cell lines but not untransformed gingival fibroblasts umbilical vein endothelial cells. Our investigation of Hep G2 cells showed a sequence associated intracellular events included (a) increased cytosolic free Ca 2+ ; (b) translocation cytochrome c (Cyto ) from mitochondria cytosol; (c)...