A5039146236- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Ubiquitin and proteasome pathways
- Immune Response and Inflammation
- Organic Electronics and Photovoltaics
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Organic Light-Emitting Diodes Research
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Genetics and Neurodevelopmental Disorders
- Conducting polymers and applications
National Yang Ming Chiao Tung University
2015-2025
Taipei Veterans General Hospital
2025
National Health Research Institutes
2024
The aryl hydrocarbon receptor (AhR) regulates peripheral immunity; but its role in microglia‐mediated neuroinflammation the brain remains unknown. Here, we demonstrate that AhR mediates both anti‐inflammatory and proinflammatory effects lipopolysaccharide (LPS)‐activated microglia. Activation of by ligands, formylindolo[3,2‐b]carbazole (FICZ) or 3‐methylcholanthrene (3MC), attenuated LPS‐induced microglial immune responses. also showed effects, as evidenced findings genetic silence...
Abstract Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates cell immune responses in type-specific and ligand-dependent manner. In the central nervous system, astrocytic AhR plays important roles regulating neuroinflammation by mediating to endogenous ligands generated from inflammation-induced indoleamine 2,3-dioxygenase 1 (IDO1)/kynurenine (KYN) pathway. We previously demonstrated reduction of expression decreases lipopolysaccharide (LPS)-induced...
Inflammation is a potential risk factor of mental disturbance. FKBP5 that encodes FK506-binding protein 51 (FKBP51), negative cochaperone glucocorticoid receptor (GR), stress-inducible gene and has been linked to psychiatric disorders. Yet, the role FKBP51 in inflammatory stress-associated disturbance remained unclear.Fkbp5-deficient (Fkbp5-KO) mice were used study stress by single intraperitoneal injection lipopolysaccharide (LPS). The anxiety-like behaviors, neuroimaging,...
Abstract Mammalian Eag1 (Kv10.1) potassium (K + ) channels are widely expressed in the brain. Several mutations gene encoding human K channel have been associated with congenital neurodevelopmental anomalies. Currently very little is known about molecules mediating protein synthesis and degradation of channels. Herein we aim to ascertain mechanism rat (rEag1). We identified cullin 7 (Cul7), a member cullin-based E3 ubiquitin ligase family, as novel rEag1 binding partner. Immunoprecipitation...
High-fat diet (HFD)-induced fatty liver disease is a deteriorating risk factor for Alzheimer's (AD). Mitigating has been shown to attenuate AD-like pathology in animal models. However, it remains unclear whether enhancing Aβ clearance through immunotherapy would turn HFD-induced or its efficacy be compromised by long-term exposure HFD. Here, the therapeutic potentials of an anti-Aβ antibody, NP106, was investigated APP/PS1 mice HFD feeding 44 weeks. The data demonstrate that NP106 treatment...
Diketopyrrolopyrrole (DPP) organic dye is well-known to have poor solubility in most common solvents. In general, flexible alkyl chain used enhance the of conjugated small molecules by disrupting attraction between molecules. this study, we integrated hybrid organic-inorganic siloxane group as a solubilizing agent on DPP molecule carrying dicyanovinyl (DCV) an electron-withdrawing group. UV-Vis absorption spectra were collected evaluate optical properties these compounds. The electrical...