A5101695568- Hypothalamic control of reproductive hormones
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- Sperm and Testicular Function
- Immune Response and Inflammation
- Growth Hormone and Insulin-like Growth Factors
- Enzyme Catalysis and Immobilization
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Tryptophan and brain disorders
- Enzyme Production and Characterization
- Neuroscience and Neural Engineering
- Alzheimer's disease research and treatments
- Ovarian function and disorders
- Mitochondrial Function and Pathology
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Cancer, Lipids, and Metabolism
- Biofuel production and bioconversion
- Diet, Metabolism, and Disease
- COVID-19 diagnosis using AI
- Influenza Virus Research Studies
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Carbohydrate Chemistry and Synthesis
National Health Research Institutes
2017-2022
Emory University
2019
Institute of Biological Chemistry, Academia Sinica
2012-2015
Hacettepe University
2010
Institute of Molecular Biology, Academia Sinica
2010
Academia Sinica
1989-2007
Institute of Cellular and Organismic Biology, Academia Sinica
2005-2006
Institute of Zoology
1994-1996
Increasing evidence suggests that elderly people with dementia are vulnerable to the development of severe coronavirus disease 2019 (COVID-19). In Alzheimer’s (AD), major form dementia, β-amyloid (Aβ) levels in blood increased; however, impact elevated Aβ on progression COVID-19 remains largely unknown. Here, our findings demonstrate Aβ1-42, but not Aβ1-40, bound various viral proteins a preferentially high affinity for spike protein S1 subunit (S1) acute respiratory syndrome 2 (SARS-CoV-2)...
In this study, we examine whether an anti‐inflammatory thiourea derivative, compound #326, actions on ion channels. The effects of #326 Ca 2+ ‐activated K + channels were evaluated by patch‐clamp recordings obtained in cell‐attached, inside‐out or whole‐cell configuration. pituitary GH 3 cells, increased the amplitude currents ( I K(Ca) ) with EC 50 value 11.6 μM, which was reversed verruculogen, but not tolbutamide TRAM‐34. Under configuration, a bath application raised probability...
Alzheimer’s disease (AD) is a progressive neurodegenerative with multifactorial etiology. A multitarget treatment that modulates multifaceted biological functions might be more effective than single-target approach. Here, the therapeutic efficacy of combination using anti-Aβ antibody NP106 and curcumin analog TML-6 versus monotherapy was investigated in an APP/PS1 mouse model AD. Our data demonstrate both attenuated brain Aβ improved nesting behavioral deficit to varying degrees....
Presentation of antigenic peptides to T-cell receptors is an essential step in the adaptive immune response. In mouse class Ib major histocompatibility complex molecule, H2-M3, presents bacterial- and mitochondrial-derived on cytotoxic T cells. Four mitochondrial heptapeptides, differing only at residue 6, form complexes with H2-M3 which can be distinguished by No structures relevant are available. To investigate structural basis for this distinction, crystal were determined molecular...
BK channel plays an important role in renal potassium secretion. G-protein pathway suppressor 2 (GPS2) is a multifunctional protein and transcriptional regulation factor that involved the mitogen-activated kinase (MAPK) signaling pathway. We have previously reported WNK4 inhibits activity by stimulating ERK1/2 p38 pathways. recently shown GPS2 enhances its expression reducing signaling-mediated degradation of channel.
Lamellar liquid crystals are promising systems for topical drug delivery [1].They transition states, possessing both the crystalline characteristics of solids and flow properties liquids [2].They composed oil, surfactant, water, generally co-surfactant, they have advantage being easily produced, increasing solubility poorly water-soluble compounds, delivering fragile substances, controlling release drugs [3, 4].In this work, SWAXS analysis some Lyotropic Liquid Crystal Formulations was...
The enzyme β‐galactosidase catalyzes the hydrolysis of lactose into glucose and galactose. An extracellular 489‐amino acid length 57‐kDa molecular weight monomer was isolated, expressed purified from an extreme thermophile, Thermococcus kodakarensis KOD1. Here, kinetic parameters β‐Galactosidase were analyzed through yellow chromogenic substrate, chlorophenol red β‐D‐galactopyranoside (CPRG). Ad, colored product measured. optimum pH temperature for activity 6.5 100°C. maximum retained even...
The COVID-19 pandemic has become a global catastrophe, affecting the health and economy of human community. It is required to mitigate impact pandemics by developing rapid molecular diagnostics for SARS-CoV-2 virus detection. In this context, study aims at presenting real-time, handheld portable POC device various viral antigen detection, including recombinant spike glycoprotein pseudovirus. This initiates development first improved detection based on one-step-one-pot hydrothermally derived...