A5036138893- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Autophagy in Disease and Therapy
- Cardiovascular and Diving-Related Complications
- Synthesis and Catalytic Reactions
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Prostate Cancer Treatment and Research
- Corneal surgery and disorders
- Heavy Metal Exposure and Toxicity
- Tracheal and airway disorders
- Visual perception and processing mechanisms
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Sulfur-Based Synthesis Techniques
- Hormonal and reproductive studies
- Bone health and treatments
- Radical Photochemical Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- RNA regulation and disease
- Synthesis of heterocyclic compounds
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Heavy metals in environment
- Nasal Surgery and Airway Studies
- melanin and skin pigmentation
Kaohsiung Chang Gung Memorial Hospital
2003-2024
Chang Gung University
2003-2024
Kaohsiung Medical University
2020-2024
National Sun Yat-sen University
2024
National Taiwan University
2017-2024
Taipei Tzu Chi Hospital
2018
Chung Yuan Christian University
2016-2017
National Taiwan Ocean University
2007-2015
Institute of Cellular and Organismic Biology, Academia Sinica
2015
National Cheng Kung University
2014
Aim: The aim of this study was to evaluate the efficacy 0.05% atropine solution for controlling myopia progression in school-aged children. Results: This retrospective, case-control enrolled myopic children who had presented at Kaohsiung Chang Gung Memorial Hospital (Kaohsiung, Taiwan) from 2001 2004. A group 57 (30 boys, 27 girls; 6–12 years age) with regular follow-up divided into a subgroup 21 (12 9 girls) received eyedrops (0.05%) every evening, and 36 (18 18 girls), remained untreated,...
Abstract Objectives/Hypothesis The ideal treatment for allergic rhinitis refractory to medical therapy is still lacking. aim of the study evaluate efficacy turbinate surgery with radiofrequency that unresponsive therapy. Study Design A prospective, nonrandomized clinical study. Methods From February 2000 April 2002, 108 consecutive patients (45 men and 63 women [mean age, 29.5 y]) who underwent were enrolled in Postoperative follow‐up ranged from 12 26 months. standard 0‐to‐10 visual...
Many studies reported that microRNAs (miRNAs) target autophagy-related genes to affect carcinogenesis, however, autophagy-deficiency-related miRNA dysfunction in cancer development remains poorly explored. During autophagic progression, we identified miR-449a as the most up-regulated miRNA. MiR-449a expression was low tumor parts of CRC patient specimens and inversely correlated with stage metastasis AUC (area under curve) 0.899 0.736 well poor overall survival rate, indicating has potential...
Abstract Background The c.G6055A (p.G2019S) mutation in leucine-rich repeat kinase 2 ( LRRK2 ) is the most prevalent genetic cause of Parkinson’s disease (PD). CRISPR/Cas9-mediated genome editing by homology-directed repair (HDR) has been applied to correct but may create small insertions and deletions (indels) due double-strand DNA breaks. Adenine base editors (ABEs) could convert targeted A·T G·C genomic without However, correction efficiency ABE remains unknown yet. This study aimed...
Abstract Formosanin C (FC) is a natural compound extracted from Paris formosana Hayata with anticancer activity. FC induces both autophagy and apoptosis in human lung cancer cells. FC‐induced depolarization of mitochondrial membrane potential (MMP) may trigger mitophagy. In this study, we clarified the effect on autophagy, mitophagy, role FC‐related cell death motility. We found caused continuous increase LC3 II (representing autophagosomes) 24 to 72 h without degradation after treatment...
Autophagic machinery is involved in selective and non-selective recruitment as well degradation or exocytosis of cargoes, including pathogens. Dengue virus (DENV) infectioninduces autophagy that enhances replication vesicle release to evade immune systemsurveillance. This study reveals DENV2 induces lung liver cancer cells andshowed capsid, envelope, NS1, NS3, NS4B host cell proinflammatory high mobilitygroup box 1 (HMGB1) proteins associated with autophagosomes which were purified by...
Grouper iridovirus (GIV) belongs to the genus Ranavirus of family Iridoviridae; genomes such viruses contain an anti-apoptotic caspase recruitment domain (CARD) gene. The GIV-CARD gene encodes a protein 91 amino acids with molecular mass 10,505 Daltons, and shows high similarity other viral CARD genes human ICEBERG. In this study, we used Northern blot demonstrate that transcription begins at 4 h post-infection; furthermore, report its is completely inhibited by cycloheximide but not...
Objective To identify standard clinical parameters that may predict the presence and severity of obstructive sleep apnea/hypopnea syndrome (OSA). Design Case series with chart review. Setting Tertiary academic medical center. Subjects Methods A total 325 adult patients (274 men 51 women; mean age, 44.2 years) habitual snoring completed comprehensive polysomnography anthropometric measurements, including modified Mallampati grade (also known as updated Friedman's tongue position [uFTP]),...
To develop an adequate model using reliable clinical and physical factors to predict pediatric obstructive sleep apnea/hypopnea syndrome (OSAS).Complete anthropometric measurements including BMI z score, tonsil size grading, updated Friedman tongue position (uFTP) were evaluated. Subjective assessments of symptoms/signs, snoring visual analog scale (VAS), nasal obstruction, mouth breathing, recorded.Eighty-eight children (57 boys 31 girls, mean age = 9.0 years) confirmed have OSAS by...
Abstract Low testosterone level is an independent predictor of osteoporotic fracture in elderly men as well increased risk undergoing androgen deprivation. Androgens and receptor (AR) actions are essential for bone development homeostasis but their linkage to repair remains unclear. Here we found that AR highly expressed the periosteum cells co-localized with a mesenchymal progenitor cell marker, paired-related homeobox protein 1 (Prrx1), during repair. Mice lacking gene expressing Prrx1-cre...
To compare peripapillary and macular vascular densities (PVDs MVDs) between patients with obstructive sleep apnea/hypopnea syndrome (OSA) control subjects symptoms of sleep-related breathing disorders only by swept-source optical coherence tomography angiography (OCTA).In this prospective study, 192 participants underwent a full-night polysomnography to determine OSA severity subsequently received OCTA measurements as well AngioTool software analysis.A total 146 (51 mild, 43 moderate, 52...
The increased risk of cardiovascular diseases owing to a high level serum homocysteine has been widely reported. Literature demonstrated that patients with obstructive sleep apnea/hypopnea syndrome (OSA) had higher than control group. This study aimed investigate the alteration levels in severe OSA receiving transoral robotic surgery (TORS).Retrospective chart review.Tertiary academic medical center.Data polysomnography (PSG) and before at least 3 months after were collected analyzed via...
Evidence has proved that high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) were risk factors for cardiovascular comorbidities. The alterations of NLR PLR following obstructive sleep apnea (OSA) treatment under studied thus should be investigated. This study aimed to evaluate the changes inflammatory biomarkers including in severe OSA patients after surgical interventions upper airway, their relationships with improvements polysomnographic (PSG) parameters.This...
Background: Diffuse large B-cell lymphoma (DLBCL) is a malignant lymphoid tumor disease that characterized by heterogeneity, but current treatment does not benefit all patients, which highlights the need to identify oncogenic genes and appropriate drugs. G9a histone methyltransferase catalyzes H3 lysine 9 (H3K9) methylation regulate gene function expression in various cancers. Methods: TCGA GTEx data were analyzed using GEPIA2 platform. Cell viability under drug was assessed Alamar Blue...
The aim was to investigate the visual outcomes of treatment with spectacles for bilateral high refractive amblyopia in children three eight years age.Children previously untreated were enrolled. Bilateral defined as acuity (VA) being worse than 6/9 both eyes presence 5.00 D or more hyperopia, myopia and 2.00 astigmatism. Full myopic astigmatic errors corrected, hyperopic corrected within 1.00 full correction. All received assessments at four-weekly intervals. VA, Worth four-dot test Randot...
Autophagy can be classified as degradative and secretory based on distinct functions. The small GTPase proteins Rab8a Rab37 are responsible for autophagy-mediated exocytosis of IL-1β, insulin, TIMP1 (tissue inhibitor 54 metalloproteinase 1). Other Rab family members participating in autophagy poorly understood. Herein, we identified 26 overlapped purified autophagosomes mouse pancreatic β-cell "Min-6" human lung cancer cell "CL1-5-Q89L" with high tendency by LC-MS/MS proteomics analysis. Six...
Autophagy is a self-recycling machinery to maintain cellular homeostasis by degrading harmful materials in the cell. Autophagy-related gene 5 (Atg5) required for autophagosome maturation. However, role of Atg5 tumorigenesis under autophagy deficient conditions remains unclear. This study focused on autophagy-independent and underlying mechanism tumorigenesis. We demonstrated that knockout autophagy-related genes including Atg5, Atg7, Atg9, p62 mouse embryonic fibroblast (MEF) cells...
The impact of using antidepressant on the occurrence tardive syndrome is rarely studied. Here we aimed to investigate prevalence various types antidepressant-induced syndrome. This study was conducted by means a retrospective survey. Subjects receiving antidepressant(s) for over 6 months, but no other agents that may cause involuntary movements, were consecutively recruited. Tardive evaluated in every included subject. Possible confounding medical conditions carefully ruled out. Of 158...
Objectives This study is designed to investigate the effects of obstructive sleep apnea/hypopnea syndrome (OSA) surgery on serum leptin levels and metabolic disturbances, both which contribute risk cardiovascular diseases. Study Design Case series with planned data collection. Setting Tertiary referral medical center. Subjects Methods A retrospective chart review 101 consecutive patients OSA who refused or failed conservative therapy then underwent upper airway for treatment was conducted....
Obstructive sleep apnea/hypopnea syndrome (OSA) results in repeated oxygen desaturation, arousals, and episodic nocturnal activation of sympathetic nervous system during sleep. Untreated OSA is strongly associated with an increase cardio- cerebrovascular disorders, as well the damages ophthalmological microstructures. However, previous literature only simply studied association between ophthalmic disorders OSA. In present study, we first investigated alterations ocular surface tear film...
Abstract In Taiwan, the prevalence of myopia in children between 6 and 18 years old is over 80%, high accounts for 20%, which turned out to be leading place worldwide. Orthokeratology low-dose atropine are proven treatments reduce progression, though potential corneal disturbances remain an issue young populations. The alteration tear film widely discussed but there no consensus date, so we aim investigate spatial instability with control using or orthokeratology. Thirty-eight...