A5033369742- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Nuclear Receptors and Signaling
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Dysphagia Assessment and Management
- Lysosomal Storage Disorders Research
- Dementia and Cognitive Impairment Research
- Botulinum Toxin and Related Neurological Disorders
- Restless Legs Syndrome Research
- Autism Spectrum Disorder Research
- Cell Image Analysis Techniques
- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- CRISPR and Genetic Engineering
- Cellular transport and secretion
- Amyotrophic Lateral Sclerosis Research
- Balance, Gait, and Falls Prevention
- Neurological and metabolic disorders
- Advanced Fluorescence Microscopy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Biological and pharmacological studies of plants
National Taiwan University Hospital
2016-2025
National Taiwan University
2014-2025
National Cheng Kung University
2025
Institute of Molecular Medicine
2025
Taipei Medical University
2022-2024
National Yang Ming Chiao Tung University
2011-2024
Chang Gung University
2024
Changhua Christian Hospital
2023
National Institute on Aging
2023
National Institutes of Health
2023
Emerging evidence suggests that gut microbiome composition alterations affect neurodegeneration through neuroinflammation in the pathogenesis of Parkinson's disease (PD). Here, we evaluate microbiota and host cytokine responses a population Taiwanese patients with PD.Fecal communities from 80 PD 77 age gender-matched controls were assessed by sequencing V3-V4 region 16S ribosomal RNA gene. Diet comorbidities controlled analyses. Plasma concentrations IL-1β, IL-2, IL-4, IL-6, IL-13, IL-18,...
Background The minimal detectable change (MDC) is the smallest amount of difference in individual scores that represents true (beyond random measurement error). MDCs Timed “Up & Go” Test (TUG) and Dynamic Gait Index (DGI) people with Parkinson disease (PD) are largely unknown, limiting interpretability both measures. Objective purpose this study was to estimate TUG DGI PD. Design This investigation a prospective cohort study. Methods Seventy-two participants were recruited from special...
<h3>Objective</h3> To examine whether plasma neurofilament light chain (NfL) levels were associated with motor and cognitive progression in Parkinson disease (PD). <h3>Methods</h3> This prospective follow-up study enrolled 178 participants, including 116 PD, 22 multiple system atrophy (MSA), 40 healthy controls. We measured NfL electrochemiluminescence immunoassay. Patients PD received evaluations of cognition at baseline a mean interval 3 years. Changes the Unified Parkinson9s Disease...
<h3>Background and Objectives</h3> Short-chain fatty acids (SCFAs) are gut microbial metabolites that promote the disease process in a rodent model of Parkinson (PD), but fecal levels SCFAs patients with PD reduced. Simultaneous assessments plasma SCFA levels, their interrelationships process, scarce. We aimed to compare different subtypes healthy controls delineate interrelations link microbiota changes clinical severity PD. <h3>Methods</h3> A cohort 96 85 were recruited from National...
Intraneuronal tau aggregations are distinctive pathological features of Parkinson's disease (PD) with autosomal-dominant mutations in leucine-rich repeat kinase 2 ( LRRK2 ). The most prevalent mutation, G2019S (glycine to serine substitution at amino acid 2019), causes neurite shrinkage through unclear pathogenetic mechanisms. We found that expression mutant Drosophila dendritic arborization neurons induces mislocalization the axonal protein dendrites and dendrite degeneration....
<h3>Objective</h3> α-Synuclein is critical to the pathogenesis of Parkinson's disease (PD). Few studies examined plasma levels α-synuclein due exceptionally low level in compared with cerebrospinal fluid. We aimed investigate patients PD different severity. <h3>Methods</h3> There were total 114 participants, including 80 and 34 controls, study. Participants received a complete evaluation motor non-motor symptoms, cognitive function. applied immunomagnetic reduction-based immunoassay measure...
To evaluate the effect of discontinuing statin therapy on incidence Parkinson disease (PD) in users.Participants who were free PD and initiated recruited between 2001 2008. We examined association use statins with different lipophilicity using Cox regression model time-varying use.Among 43,810 initiators, rate for was 1.68 3.52 per 1,000,000 person-days lipophilic hydrophilic statins, respectively. Continuation associated a decreased risk (hazard ratio [HR] 0.42 [95% confidence interval...
Parkinson's disease (PD) is a common neurodegenerative disorder arising from an interplay between genetic and environmental risk factors. Studies have suggested that the pathological hallmarks of intraneuronal α-synuclein aggregations may start olfactory bulb enteric nervous system gut later propagate to brain via tract vagus nerve. This hypothesis correlates well with clinical symptoms, such as constipation, develop up 20 years before onset PD motor symptoms. Recent interest in gut-brain...
Abstract Background Recent genetic progress has allowed for the molecular diagnosis of Parkinson's disease. However, causes PD vary widely in different ethnicities. Mutational frequencies and clinical phenotypes genes associated with Asian populations are largely unknown. The objective this study was to identify mutational spectrums multiple PD‐causative a Taiwanese cohort. Methods A total 571 participants including 324 patients early‐onset parkinsonism (onset age, <50 years) 247...
Abstract Background As gene‐targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction the estimated number subjects with monogenic PD worldwide currently represented in literature availability clinical data trial‐ready cohorts limited. Objective The objectives to (1) establish an international cohort affected unaffected individuals PD‐linked variants;...
We and others found two polymorphic LRRK2 (leucine-rich repeat kinase 2) variants (rs34778348:G>A; p.G2385R rs33949390:G>C; p.R1628P) associated with Parkinson disease (PD) among Chinese patients, but the common worldwide rs34637584:G>A; p.G2019S mutation, was absent. Focusing exclusively on Han Chinese, we first sequenced coding regions in young onset familial PD patients identified 59 variants. then examined these 250 control subjects. Among 17 variants, five demonstrated different...
Background and Purpose Hypertension has been associated with Parkinson's disease (PD), but data on antihypertensive drugs PD are inconclusive. We aim to evaluate for an association in hypertensive patients. Methods Hypertensive patients who were free of PD, dementia stroke recruited from 2005–2006 using Taiwan National Health Insurance Database. examined the between use calcium channel blockers (CCBs), angiotensin converting enzyme inhibitors (ACEIs), receptor (ARBs) incidence beta-blockers...
Parkinson's disease (PD) is a common neurodegenerative disorder that exhibits motor and non-motor symptoms, as well pathological hallmarks, including dopaminergic (DA) neuron death formation of α-synuclein (α-Syn) Lewy bodies. Cyclin-G-associated kinase (GAK), PD susceptibility gene identified through genome-wide association studies (GWAS), ubiquitous serine/threonine involved in clathrin uncoating, though its PD-related function remains elusive. Here, we implicate the Drosophila GAK...
Identifying trends in the prevalence and incidence of Parkinson's disease (PD) may yield information that supports public health goals. Our aim was to evaluate time-trend changes PD Taiwan between 2004 2011.This retrospective, nationwide, longitudinal study used National Health Insurance Research Database identify patients with from 2011 based on having ICD-9-CM diagnostic codes, which were assigned by neurologists, being prescribed medication. Annual calculated, analyses estimated assuming...
It is difficult to discriminate healthy subjects and patients with Parkinson disease (PD) or dementia (PDD) by assaying plasma α-synuclein because the concentrations of circulating in blood are almost same as low-detection limit using current immunoassays, such enzyme-linked immunosorbent assay. In this work, an ultra-sensitive immunoassay utilizing immunomagnetic reduction (IMR) developed. The reagent for IMR consists magnetic nanoparticles functionalized antibodies against dispersed pH-7.2...
Objective: Parkinson's disease (PD) has significant clinical overlaps with atypical Parkinsonism syndromes (APS), which have a poorer treatment response and more aggressive course than PD. We aimed to identify plasma biomarkers differentiate PD from APS. Methods: Plasma samples (n=204) were obtained healthy controls patients PD, dementia Lewy bodies (DLB), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), or frontotemporal (FTD-P) without...
Abstract Background Leucine‐rich repeat kinase 2 ( LRRK2 ) is a common risk gene for Parkinson's disease (PD) and inflammatory bowel disorders. However, the penetrance of most prevalent mutation, G2019S, <50%. Factors other than genetic mutations are needed in PD process. Objectives To examine whether how gut inflammation may act as an environmental trigger to neurodegeneration PD. Methods A mild chronic dextran sodium sulfate (DSS)‐induced colitis mice model harboring G2019S mutation was...