A5038099730- Alzheimer's disease research and treatments
- Characterization and Applications of Magnetic Nanoparticles
- Dementia and Cognitive Impairment Research
- Physics of Superconductivity and Magnetism
- Atomic and Subatomic Physics Research
- Parkinson's Disease Mechanisms and Treatments
- Magnetic properties of thin films
- Advanced Biosensing Techniques and Applications
- Photonic Crystals and Applications
- Geomagnetism and Paleomagnetism Studies
- Nanoparticle-Based Drug Delivery
- Biosensors and Analytical Detection
- Microfluidic and Bio-sensing Technologies
- Photonic and Optical Devices
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Theoretical and Computational Physics
- Magneto-Optical Properties and Applications
- Fern and Epiphyte Biology
- Liquid Crystal Research Advancements
- Functional Brain Connectivity Studies
- Surfactants and Colloidal Systems
- Magnetic and transport properties of perovskites and related materials
- Quantum and electron transport phenomena
Ningbo Medical Center Lihuili Hospital
2025
Ningbo University
2025
National Chung Hsing University
2021
Systems, Applications & Products in Data Processing (Canada)
2015
Optica
1999-2014
National Taiwan Normal University
2005-2014
Quanta Computer (Taiwan)
2010-2014
Electro Optical Systems (Germany)
1999-2012
National Taiwan University
2011
University of California, Irvine
2007
Neurofibrillary tangles are associated with cognitive dysfunction, and hippocampal atrophy increased CSF tau markers. However, the plasma levels of Alzheimer's disease (AD) have not been well studied. We investigated by using an immunomagnetic reduction assay in 20 patients mild impairment (MCI) due to AD, 10 early AD dementia, 30 healthy elders (HE). All received a 3D-brain MRI scan set function test. explored their relationships both brain structure functions. Images were analyzed...
<h3>Objective</h3> α-Synuclein is critical to the pathogenesis of Parkinson's disease (PD). Few studies examined plasma levels α-synuclein due exceptionally low level in compared with cerebrospinal fluid. We aimed investigate patients PD different severity. <h3>Methods</h3> There were total 114 participants, including 80 and 34 controls, study. Participants received a complete evaluation motor non-motor symptoms, cognitive function. applied immunomagnetic reduction-based immunoassay measure...
A highly sensitive immunoassay, the immunomagnetic reduction, is used to measure several biomarkers for plasma that related Alzheimer's disease (AD). These include Aβ-40, Aβ-42, and tau proteins. The samples are composed of four groups: healthy controls (n = 66), mild cognitive impairment (MCI, n 22), very dementia 23), mild-to-serve dementia, all due AD 22). It found concentrations both Aβ-42 protein significantly lower than those other groups. sensitivity specificity in differentiating MCI...
The feasibility of assaying plasma phosphorylated tau protein (threonine 181), denoted p-tau181, using immunomagnetic reduction (IMR) is explored. reagent for p-tau181 with IMR was synthesized, and its analytic performances were characterized. Seventy-three subjects recruited. Each participant examined neuropsychological tests, magnetic resonance imaging, assay p-tau181. Using commercially available kits, the total (T-tau) each subject assayed. dynamic range 1.96×10 -2 pg/ml to 10 4 pg/ml....
The 42 amino acid form of amyloid-β (Aβ ) plays a key role in the pathogenesis Alzheimer’s disease (AD) and is core biomarker for diagnosis AD. Numerous studies have shown that cerebrospinal fluid (CSF) Aβ concentrations are decreased AD, when measured by enzyme-linked immunosorbent assay (ELISA) other conventional immunoassays. While most report no change plasma , independent using immunomagnetic reduction (IMR) technique an increase levels To confirm opposite changes CSF we assayed...
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease, and α-synuclein plays a critical role in pathogenesis of PD. Studies have revealed controversial results regarding correlation between motor severity levels peripheral blood from patients with Objective: We examined plasma or serum PD investigated relationship level symptom severity. Methods: recruited 88 participants (48 40 healthy controls). Clinical information was collected, venous drawn each...
Magnetic nanoparticles biofunctionalized with antibodies against β-amyloid-40 (Aβ-40) and Aβ-42, which are promising biomarkers related to Alzheimer's disease (AD), were synthesized. We characterized the size distribution, saturated magnetizations, stability of magnetic conjugated anti-Aβ antibody. In combination immunomagnetic reduction technology, it is demonstrated such able label Aβs specifically. The ultralow-detection limits assaying in vitro using via determined a concentration ∼10...
The utility of plasma amyloid beta (Aβ) and tau levels for the clinical diagnosis Alzheimer's disease (AD) dementia has been controversial. main objective this study was to compare Aβ42 measured by ultra-sensitive immunomagnetic reduction (IMR) assays in samples collected at Banner Sun Health Institute (BSHRI) (United States) with those from National Taiwan University Hospital (NTUH) (Taiwan). Significant increase were detected AD subjects both cohorts, while increased only NTUH cohort. A...
The field-dependent refractive index (nMF–H curve) of the magnetic fluid film (MFF) is measured at various temperatures to investigate thermal effect on index. It was found, a certain temperature, that becomes higher under fields. This nMF–H curve moved toward region with lower nMF when temperature raised. Since variation in MF external fields due formation columns, structural patterns are then examined clarify origin change temperature. Under given field strength, particles columns...
Recent advances in biomarkers provide the possibility of early or preclinical diagnosis Alzheimer's pathology. Currently, decreased levels Aβ-42 and increased tau proteins cerebral spinal fluid are considered reliable disease (AD); however, little evidence exists for use amyloid protein plasma as useful biomarkers. We investigated potential to diagnose AD explored their relationships with brain Aβ deposition imaging. used an immunomagnetic reduction assay measure Aβ40, Aβ42, 20 older control...
It is difficult to discriminate healthy subjects and patients with Parkinson disease (PD) or dementia (PDD) by assaying plasma α-synuclein because the concentrations of circulating in blood are almost same as low-detection limit using current immunoassays, such enzyme-linked immunosorbent assay. In this work, an ultra-sensitive immunoassay utilizing immunomagnetic reduction (IMR) developed. The reagent for IMR consists magnetic nanoparticles functionalized antibodies against dispersed pH-7.2...
BACKGROUND: Phosphorylated tau (p-tau) is a specific blood biomarker for Alzheimers disease (AD) pathology. Multiple p-tau biomarkers on several analytical platforms are poised clinical use. The Association Global Biomarker Standardisation Consortium plasma phospho-tau Round Robin study engaged assay developers in blinded case-control p-tau, aiming to learn which assays provide the largest fold-changes AD compared non-AD, have strongest relationship between and cerebrospinal fluid (CSF),...
We developed a setup to probe the refractive index of magnetic fluid films under external fields. This possesses high resolution 0.0001 in measured index. It was found that depends linearly on concentration dilute zero field. For given film, increases with increasing field strength over critical value, and then becomes saturated as reaches around 200 Oe. is noteworthy magnetically modulated could have great potential electro-optical applications.
To reduce interface loss between optical fibers and devices in telecommunication systems, the development of an optical-fiber-based device that can be fused directly with is important. A novel modulator consisting a bare fiber core surrounded by magnetic fluids instead SiO2 cladding layer proposed. Applying field raises refractive index fluid. Thus we control occurrence total reflection at fluid when light propagates along fiber. As result, intensity outgoing modulated variation strength....
Although there is a consensus on the reduced levels of Aβ1-42 in CSF patients with AD, studies plasma Aβ were inconsistent and have limited clinical value. We developed an immunomagnetic reduction assay (IMR) to determine Aβ. surveyed varying AD severity (CDR = 0.5, n=16; CDR ≥ 1, n=18) controls (n=26). Significant group differences apparent (F 5.54, p 0.002) Aβ1-42/Aβ1-40 ratio 24.198, < 0.001). Post-hoc analyses showed significant (p 0.001) control, MCI subjects (all ≤ Regression analysis...
Background: Neuritic plaques and neurofibrillary tangles are the pathological hallmarks of Alzheimer's disease (AD), while role brain amyloid deposition in clinical manifestation or atrophy remains unresolved. We aimed to explore relation between deposition, cortical thickness plasma biomarkers. Method: used 11C-Pittsburgh compound B-positron emission tomography assay magnetic resonance imaging estimate an immunomagnetic reduction measure recruited 39 controls, 25 subjects with amnesic mild...
The Alzheimer's Association Global Biomarker Standardization Consortium conducted a blinded case-control study to learn which phosphorylated tau (p-tau) assays provide the largest fold-changes in disease (AD) versus non-AD and show commutability measuring patient samples candidate certified reference materials (CRMs). Thirty-three different p-tau measured paired plasma cerebrospinal fluid (CSF) from 40 participants (25 with "AD pathology" 15 "non-AD by CSF amyloid beta [Aβ]42/Aβ40 p-tau181...
Objective: Traumatic brain injury (TBI) patients with decompressive craniectomy (DC) frequently accompany the complication of secondary subdural effusion (SDE). In cases where cranioplasty is contraindicated, there are no clear-cut guidelines on surgical approaches for managing resulting from DC. Therefore, authors conducted this study to compare different procedures SDE in context contraindications cranioplasty. Methods: The clinical data 59 following DC TBI, who had contraindication and...
The physical mechanism of the optical transmission magnetic fluid films under perpendicular fields is investigated in this work. Under fields, originally dispersed particles agglomerate to form columns. liquid phase transparent, whereas columns are opaque. Hence, dominates film. When field strength raised, more formed, and area reduced. This leads decrease film higher strength. variation concentration various strengths also contributes By taking account variations effective ratio resultant...
Immunomagnetic reduction (IMR), which involves the use of antibody-functionalized magnetic nanoparticles to specifically label target biomarkers, was utilized develop an assay for total tau protein in human plasma. The analytic properties IMR on were investigated. limit detection found be 0.026 pg/ml. Other such as Hook effect, linearity, dilution recovery range, reagent stability, interference test, and spiked also characterized. ultra-sensitive applied detect plasma levels subjects with...
Background: Changes in beta-amyloids and tau proteins have been noted patients with Alzheimer's disease (AD) both Down syndrome (DS) AD. However, reports of changes the early stage regression, such as behavioral psychological symptoms dementia (BPSD), DS are sparse. Methods: Seventy-eight controls, 62 AD, 35 DS, 16 degeneration (DS_D), including 9 BPSD 7 dementia, were enrolled. The levels 40 42 (Abeta-40, Abeta-42) protein blood analyzed using immunomagnetic reduction. Adaptive Behavior...
In this study, we assessed plasma biomarkers to identify cognitive impairment in Parkinson's disease (PD) patients by applying ultra-sensitive immunomagnetic reduction-based immunoassay (IMR).The study enrolled 60 PD and 28 age- sex-matched normal controls. Complete function assessments were performed on participants using the Mini-Mental State Examination (MMSE) Clinical Dementia Rating. with an MMSE score of ≦26 defined as having impairment. Meanwhile, a 99mTc-TRODAT-1 scan was levels...
Abstract Introduction Blood‐based assays to measure brain amyloid beta (Aβ) deposition are an attractive alternative the cerebrospinal fluid (CSF)–based currently used in clinical settings. In this study, we examined different blood‐based Aβ and how they compare among centers assays. Methods Aliquots from 81 plasma samples were distributed 10 participating centers. Seven immunological four mass‐spectrometric methods concentrations. Results Correlations weak for Aβ42 while Aβ40 correlations...