A5003948893- Medical Imaging Techniques and Applications
- Fluorine in Organic Chemistry
- Neurotransmitter Receptor Influence on Behavior
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Organoselenium and organotellurium chemistry
- Forensic Toxicology and Drug Analysis
- Treatment of Major Depression
- Synthesis and Reactions of Organic Compounds
- Metabolism, Diabetes, and Cancer
- Chemical Reaction Mechanisms
- Alzheimer's disease research and treatments
- Cannabis and Cannabinoid Research
- Glioma Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Biotin and Related Studies
- Carbohydrate Chemistry and Synthesis
- Inorganic Fluorides and Related Compounds
National Taiwan University Hospital
2012-2022
Tri-Service General Hospital
2011-2022
National Defense Medical Center
2011-2022
National Taiwan University
2011-2022
National Cheng Kung University
2015
Changhua Christian Hospital
2015
Tri-Service General Hospital Beitou Branch
2015
Tainan Municipal Hospital
2015
Buddhist Tzu Chi General Hospital
2015
University of Pennsylvania
1995-2009
s of Articles on Computed Tomography from Non-Radiological Journals: RADIOCHEMISTRY: PDF Only
The rate constants and lumped (LCs) for [ 18 F]fluorodeoxyglucose ([ F]FDG) 11 C]deoxyglucose C]DG) were determined in humans the glucose metabolic kinetic model used to measure local cerebral consumption. mean values (±SE) of LCs F]FDG C]DG are 0.52 ± 0.028 (n = 9) 0.56 0.043 6), respectively. k* 1 , 2 3 4 gray matter 0.095 0.005, 0.125 0.002, 0.069 0.0055 0.0003, corresponding white 0.065 0.126 0.003, 0.066 0.0054 0.0006, Using these previously published C]DG, average whole-brain rates...
To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, authors evaluated [18F]N-methylspiroperidol binding using positron emission tomography 10 abusers and normal control subjects. Cocaine who had been detoxified for 1 week or less showed significantly lower values uptake striatum than whereas month comparable to those obtained from The conclude that postsynaptic receptor availability decreases with abuse but may recover after a drug-free interval.
Because CNS neuroleptic concentration cannot be directly measured in patients, the relation between clinical response and extent of dopamine receptor blockade is unknown. This relationship critical ascertaining whether nonresponse to neuroleptics result merely inadequate drug levels or more basic biological differences pathophysiology. Using [18F]N-methylspiroperidol positron emission tomography, authors assessed occupancy 10 schizophrenic patients before after treatment with haloperidol....
The deoxyglucose technique for the measurement of local cerebral glucose metabolism (LCMRgl) has been widely applied in animals utilizing 14C-deoxyglucose and humans employing 18F-fluorodeoxyglucose. Repeat studies over a relatively brief period time have not possible because 110-min half-life fluorine-18. With synthesis 11C-deoxyglucose it now become to utilize this short-lived (20 min) tracer LCMRgl determine its variability within subjects 2-h period. kinetic rate constants were...
Recent advances in biomarkers provide the possibility of early or preclinical diagnosis Alzheimer's pathology. Currently, decreased levels Aβ-42 and increased tau proteins cerebral spinal fluid are considered reliable disease (AD); however, little evidence exists for use amyloid protein plasma as useful biomarkers. We investigated potential to diagnose AD explored their relationships with brain Aβ deposition imaging. used an immunomagnetic reduction assay measure Aβ40, Aβ42, 20 older control...
Abstract Background Leucine‐rich repeat kinase 2 ( LRRK2 ) is a common risk gene for Parkinson's disease (PD) and inflammatory bowel disorders. However, the penetrance of most prevalent mutation, G2019S, <50%. Factors other than genetic mutations are needed in PD process. Objectives To examine whether how gut inflammation may act as an environmental trigger to neurodegeneration PD. Methods A mild chronic dextran sodium sulfate (DSS)‐induced colitis mice model harboring G2019S mutation was...
The purpose of this study was to develop a radiopharmaceutical that could be used selectively image 5-HT1A receptors with positron emission tomography (PET) No-carrier-added 4-(2′-methoxyphenyl)-1-[2′-(N-2′-pyridinyl)-p-[18F]fluorobenzamido]ethylpiperazine (p-[18F]-MPPF, 2) synthesized by the nucleophilic substitution corresponding nitro precursor 1 K[18F]/Kryptofix 2.2.2. in dimethyl sulfoxide (DMSO) at 140°C for 20 min followed purification high-performance liquid chromatography (HPLC) 10%...
Positron emission tomography (PET) with labeled neuroleptics has made possible the study of neurotransmitter-receptor systems in vivo. In this we investigate kinetics 3,4-dihydroxyphenylethylamine (dopamine) receptor-ligand binding using PET data from a series experiments baboon 18F-labeled drugs spiperone, haloperidol, and benperidol. Models used to describe these are based on first-order which applies at high specific activity (low receptor occupancy). The parameters governing uptake loss...
Background:Many lines of evidence suggest the role serotonin transporter (SERT)-mediated reuptake in pathophysiology and treatment major depressive disorder (MDD). This study aimed to examine whether pretreatment SERT binding potential or ratio between terminal projection regions relative midbrain raphe nuclei was associated with outcomes SERT-targeted antidepressants.
Background: Neuritic plaques and neurofibrillary tangles are the pathological hallmarks of Alzheimer's disease (AD), while role brain amyloid deposition in clinical manifestation or atrophy remains unresolved. We aimed to explore relation between deposition, cortical thickness plasma biomarkers. Method: used 11C-Pittsburgh compound B-positron emission tomography assay magnetic resonance imaging estimate an immunomagnetic reduction measure recruited 39 controls, 25 subjects with amnesic mild...
Much evidence supports the role of serotonin transporter (SERT) in pathophysiology and pharmacotherapy major depressive disorder (MDD) suicidal behaviors. In this study, we recruited 17 antidepressant-naïve patients with MDD age- gender-matched healthy controls. SERT availability was measured vivo N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) positron emission tomography (PET) imaging. The 21-item Hamilton Depression Rating Scale (HDRS) Beck for Suicide Ideation...
Abstract No‐carrier‐added (NCA) [ 18 F]fluorobenzene was prepared in a multistep synthesis with radiochemical yield of 20‐30%. A series NCA and CA F‐labeled aryl fluorides which are important precursors butyrophenone neuroleptics have also been synthesized yields 30–50%. The direct F]spiroperidol F]benperidol from the parent compounds and/or nitro chloro compound using nucleophilic substitution reactions were investigated.
Bezafibrate, a pan-peroxisome proliferator-activated receptor (PPAR) agonist, reportedly attenuated tau pathology in transgenic mouse model of primary tauopathy. Since is neuropathological hallmark Alzheimer's disease (AD), bezafibrate may be potential drug for the treatment AD. However, no study has investigated its effects AD models. Thus, we aimed to evaluate whether neuroprotective sporadic induced by streptozotocin (STZ) intracerebroventricular (ICV) injection. Rats were administered...